FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078366306> ?p ?o ?g. }

• W2078366306 endingPage "1039" @default.
• W2078366306 startingPage "1031" @default.
• W2078366306 abstract "The CD40 ligand (CD40L) is a member of the tumor necrosis factor (TNF) family of proteins and is transiently expressed on the surface of activated T cells. The binding of CD40L to CD40, which is expressed on the surface of B cells, provides a critical and unique pathway of cellular activation resulting in antibody isotype switching, regulation of apoptosis, and B cell proliferation and differentiation. Naturally occurring mutations of CD40L result in the clinical hyper-IgM syndrome, characterized by an inability to produce immunoglobulins of the IgG, IgA and IgE isotypes.We have determined the crystal structure of a soluble extracellular fragment of human CD40L to 2 A resolution and with an R factor of 21.8%. Although the molecule forms a trimer similar to that found for other members of the TNF family, such as TNF alpha and lymphotoxin-alpha, and exhibits a similar overall fold, there are considerable differences in several loops including those predicted to be involved in CD40 binding.The structure suggests that most of the hyper-IgM syndrome mutations affect the folding and stability of the molecule rather than the CD40-binding site directly. Despite the fact that the hyper-IgM syndrome mutations are dispersed in the primary sequence, a large fraction of them are clustered in space in the vicinity of a surface loop, close to the predicted CD40-binding site." @default.
• W2078366306 created "2016-06-24" @default.
• W2078366306 creator A5006030795 @default.
• W2078366306 creator A5010362194 @default.
• W2078366306 creator A5019361113 @default.
• W2078366306 creator A5045638230 @default.
• W2078366306 creator A5080546760 @default.
• W2078366306 creator A5081978345 @default.
• W2078366306 creator A5085140261 @default.
• W2078366306 date "1995-10-01" @default.
• W2078366306 modified "2023-10-16" @default.
• W2078366306 title "2 å crystal structure of an extracellular fragment of human CD40 ligand" @default.
• W2078366306 cites W1667210186 @default.
• W2078366306 cites W1973127065 @default.
• W2078366306 cites W1975914851 @default.
• W2078366306 cites W1983795855 @default.
• W2078366306 cites W1987653378 @default.
• W2078366306 cites W1987968095 @default.
• W2078366306 cites W1989305940 @default.
• W2078366306 cites W1990590909 @default.
• W2078366306 cites W1996607909 @default.
• W2078366306 cites W2001641653 @default.
• W2078366306 cites W2003129497 @default.
• W2078366306 cites W2003576860 @default.
• W2078366306 cites W2013789621 @default.
• W2078366306 cites W2014694459 @default.
• W2078366306 cites W2015401858 @default.
• W2078366306 cites W2029249439 @default.
• W2078366306 cites W2031338911 @default.
• W2078366306 cites W2038436168 @default.
• W2078366306 cites W2042043269 @default.
• W2078366306 cites W2042639005 @default.
• W2078366306 cites W2058527555 @default.
• W2078366306 cites W2058686825 @default.
• W2078366306 cites W2060382742 @default.
• W2078366306 cites W2060807817 @default.
• W2078366306 cites W2068488477 @default.
• W2078366306 cites W2069080743 @default.
• W2078366306 cites W2076820280 @default.
• W2078366306 cites W2090030418 @default.
• W2078366306 cites W2097467042 @default.
• W2078366306 cites W2098123605 @default.
• W2078366306 cites W2102572112 @default.
• W2078366306 cites W2108743612 @default.
• W2078366306 cites W2182386412 @default.
• W2078366306 cites W2418642082 @default.
• W2078366306 cites W3120153401 @default.
• W2078366306 doi "https://doi.org/10.1016/s0969-2126(01)00239-8" @default.
• W2078366306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8747468" @default.
• W2078366306 hasPublicationYear "1995" @default.
• W2078366306 type Work @default.
• W2078366306 sameAs 2078366306 @default.
• W2078366306 citedByCount "224" @default.
• W2078366306 countsByYear W20783663062012 @default.
• W2078366306 countsByYear W20783663062013 @default.
• W2078366306 countsByYear W20783663062014 @default.
• W2078366306 countsByYear W20783663062015 @default.
• W2078366306 countsByYear W20783663062016 @default.
• W2078366306 countsByYear W20783663062018 @default.
• W2078366306 countsByYear W20783663062019 @default.
• W2078366306 countsByYear W20783663062020 @default.
• W2078366306 countsByYear W20783663062021 @default.
• W2078366306 countsByYear W20783663062022 @default.
• W2078366306 countsByYear W20783663062023 @default.
• W2078366306 crossrefType "journal-article" @default.
• W2078366306 hasAuthorship W2078366306A5006030795 @default.
• W2078366306 hasAuthorship W2078366306A5010362194 @default.
• W2078366306 hasAuthorship W2078366306A5019361113 @default.
• W2078366306 hasAuthorship W2078366306A5045638230 @default.
• W2078366306 hasAuthorship W2078366306A5080546760 @default.
• W2078366306 hasAuthorship W2078366306A5081978345 @default.
• W2078366306 hasAuthorship W2078366306A5085140261 @default.
• W2078366306 hasBestOaLocation W20783663061 @default.
• W2078366306 hasConcept C137756551 @default.
• W2078366306 hasConcept C141105273 @default.
• W2078366306 hasConcept C153911025 @default.
• W2078366306 hasConcept C154317977 @default.
• W2078366306 hasConcept C159654299 @default.
• W2078366306 hasConcept C185592680 @default.
• W2078366306 hasConcept C202751555 @default.
• W2078366306 hasConcept C203014093 @default.
• W2078366306 hasConcept C2777991845 @default.
• W2078366306 hasConcept C2778453870 @default.
• W2078366306 hasConcept C39347974 @default.
• W2078366306 hasConcept C542903549 @default.
• W2078366306 hasConcept C54355233 @default.
• W2078366306 hasConcept C86803240 @default.
• W2078366306 hasConcept C95444343 @default.
• W2078366306 hasConceptScore W2078366306C137756551 @default.
• W2078366306 hasConceptScore W2078366306C141105273 @default.
• W2078366306 hasConceptScore W2078366306C153911025 @default.
• W2078366306 hasConceptScore W2078366306C154317977 @default.
• W2078366306 hasConceptScore W2078366306C159654299 @default.
• W2078366306 hasConceptScore W2078366306C185592680 @default.
• W2078366306 hasConceptScore W2078366306C202751555 @default.
• W2078366306 hasConceptScore W2078366306C203014093 @default.
• W2078366306 hasConceptScore W2078366306C2777991845 @default.
• W2078366306 hasConceptScore W2078366306C2778453870 @default.

• next