Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078366491> ?p ?o ?g. }
- W2078366491 endingPage "533" @default.
- W2078366491 startingPage "524" @default.
- W2078366491 abstract "N-Methyl-d-aspartate receptor (NMDAR) activation may promote cell survival or initiate cell death, with the outcome dependent on whether synaptic or extrasynaptic receptors are activated. Similarly, this differential activation has been proposed to govern the direction of plasticity. However, the physiological parameters necessary to activate extrasynaptic NMDARs in brain slices remain unknown. Using the irreversible use-dependent NMDAR antagonist MK-801 to isolate extrasynaptic NMDARs, we have tested the ability of short-stimulation trains from 5 to 400 Hz to activate these receptors on CA1 hippocampal slice pyramidal neurons. Frequencies as low as 25 Hz engage extrasynaptic NMDARs, with maximal activation at frequencies between 100 and 200 Hz. Since similar bursts of synaptic input occur during exploratory behavior in rats, our results demonstrate that “extrasynaptic” NMDARs regularly participate in synaptic transmission. Further, 175-Hz-stimulation trains activate all available synaptic and extrasynaptic dendritic NMDARs, suggesting these NMDARs act as synaptic receptors as needed, transiently increasing synaptic strength. Thus extrasynaptic NMDARs play a vital role in synaptic physiology, calling into question their status as “extrasynaptic.”" @default.
- W2078366491 created "2016-06-24" @default.
- W2078366491 creator A5003641072 @default.
- W2078366491 creator A5012194117 @default.
- W2078366491 date "2008-02-01" @default.
- W2078366491 modified "2023-09-25" @default.
- W2078366491 title "Recruiting Extrasynaptic NMDA Receptors Augments Synaptic Signaling" @default.
- W2078366491 cites W1558113371 @default.
- W2078366491 cites W1567566461 @default.
- W2078366491 cites W1571617145 @default.
- W2078366491 cites W1585306115 @default.
- W2078366491 cites W1597908762 @default.
- W2078366491 cites W1626546769 @default.
- W2078366491 cites W1646272776 @default.
- W2078366491 cites W1690684669 @default.
- W2078366491 cites W1825044724 @default.
- W2078366491 cites W1858043581 @default.
- W2078366491 cites W1967228524 @default.
- W2078366491 cites W1975888261 @default.
- W2078366491 cites W1978152102 @default.
- W2078366491 cites W1980059018 @default.
- W2078366491 cites W1989932452 @default.
- W2078366491 cites W1994664430 @default.
- W2078366491 cites W1998274407 @default.
- W2078366491 cites W2013479315 @default.
- W2078366491 cites W2016379134 @default.
- W2078366491 cites W2024990606 @default.
- W2078366491 cites W2028594041 @default.
- W2078366491 cites W2035082265 @default.
- W2078366491 cites W2037210922 @default.
- W2078366491 cites W2047750300 @default.
- W2078366491 cites W2052646014 @default.
- W2078366491 cites W2075603142 @default.
- W2078366491 cites W2075952655 @default.
- W2078366491 cites W2080811912 @default.
- W2078366491 cites W2081070804 @default.
- W2078366491 cites W2084359253 @default.
- W2078366491 cites W2102741991 @default.
- W2078366491 cites W2104417933 @default.
- W2078366491 cites W2104841526 @default.
- W2078366491 cites W2118064450 @default.
- W2078366491 cites W2118974644 @default.
- W2078366491 cites W2120048206 @default.
- W2078366491 cites W2141984765 @default.
- W2078366491 cites W2152402650 @default.
- W2078366491 cites W2156094132 @default.
- W2078366491 cites W2157867129 @default.
- W2078366491 cites W2161998020 @default.
- W2078366491 cites W2302128506 @default.
- W2078366491 cites W2405131939 @default.
- W2078366491 doi "https://doi.org/10.1152/jn.01169.2007" @default.
- W2078366491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18057106" @default.
- W2078366491 hasPublicationYear "2008" @default.
- W2078366491 type Work @default.
- W2078366491 sameAs 2078366491 @default.
- W2078366491 citedByCount "65" @default.
- W2078366491 countsByYear W20783664912012 @default.
- W2078366491 countsByYear W20783664912013 @default.
- W2078366491 countsByYear W20783664912014 @default.
- W2078366491 countsByYear W20783664912015 @default.
- W2078366491 countsByYear W20783664912016 @default.
- W2078366491 countsByYear W20783664912017 @default.
- W2078366491 countsByYear W20783664912018 @default.
- W2078366491 countsByYear W20783664912019 @default.
- W2078366491 countsByYear W20783664912020 @default.
- W2078366491 countsByYear W20783664912021 @default.
- W2078366491 countsByYear W20783664912023 @default.
- W2078366491 crossrefType "journal-article" @default.
- W2078366491 hasAuthorship W2078366491A5003641072 @default.
- W2078366491 hasAuthorship W2078366491A5012194117 @default.
- W2078366491 hasConcept C127445978 @default.
- W2078366491 hasConcept C148762608 @default.
- W2078366491 hasConcept C169760540 @default.
- W2078366491 hasConcept C170493617 @default.
- W2078366491 hasConcept C185592680 @default.
- W2078366491 hasConcept C200170125 @default.
- W2078366491 hasConcept C24998067 @default.
- W2078366491 hasConcept C55493867 @default.
- W2078366491 hasConcept C61174792 @default.
- W2078366491 hasConcept C67018056 @default.
- W2078366491 hasConcept C86803240 @default.
- W2078366491 hasConcept C98229152 @default.
- W2078366491 hasConceptScore W2078366491C127445978 @default.
- W2078366491 hasConceptScore W2078366491C148762608 @default.
- W2078366491 hasConceptScore W2078366491C169760540 @default.
- W2078366491 hasConceptScore W2078366491C170493617 @default.
- W2078366491 hasConceptScore W2078366491C185592680 @default.
- W2078366491 hasConceptScore W2078366491C200170125 @default.
- W2078366491 hasConceptScore W2078366491C24998067 @default.
- W2078366491 hasConceptScore W2078366491C55493867 @default.
- W2078366491 hasConceptScore W2078366491C61174792 @default.
- W2078366491 hasConceptScore W2078366491C67018056 @default.
- W2078366491 hasConceptScore W2078366491C86803240 @default.
- W2078366491 hasConceptScore W2078366491C98229152 @default.
- W2078366491 hasIssue "2" @default.
- W2078366491 hasLocation W20783664911 @default.
- W2078366491 hasLocation W20783664912 @default.
- W2078366491 hasOpenAccess W2078366491 @default.