FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078366840> ?p ?o ?g. }

• W2078366840 endingPage "e80733" @default.
• W2078366840 startingPage "e80733" @default.
• W2078366840 abstract "The ascomycetes Candida albicans, Saccharomyces cerevisiae and Scheffersomyces stipitis metabolize the pentose sugar xylose very differently. S. cerevisiae fails to grow on xylose, while C. albicans can grow, and S. stipitis can both grow and ferment xylose to ethanol. However, all three species contain highly similar genes that encode potential xylose reductases and xylitol dehydrogenases required to convert xylose to xylulose, and xylulose supports the growth of all three fungi. We have created C. albicans strains deleted for the xylose reductase gene GRE3, the xylitol dehydrogenase gene XYL2, as well as the gre3 xyl2 double mutant. As expected, all the mutant strains cannot grow on xylose, while the single gre3 mutant can grow on xylitol. The gre3 and xyl2 mutants are efficiently complemented by the XYL1 and XYL2 from S. stipitis. Intriguingly, the S. cerevisiae GRE3 gene can complement the Cagre3 mutant, while the ScSOR1 gene can complement the Caxyl2 mutant, showing that S. cerevisiae contains the enzymatic capacity for converting xylose to xylulose. In addition, the gre3 xyl2 double mutant of C. albicans is effectively rescued by the xylose isomerase (XI) gene of either Piromyces or Orpinomyces, suggesting that the XI provides an alternative to the missing oxido-reductase functions in the mutant required for the xylose-xylulose conversion. Overall this work suggests that C. albicans strains engineered to lack essential steps for xylose metabolism can provide a platform for the analysis of xylose metabolism enzymes from a variety of species, and confirms that S. cerevisiae has the genetic potential to convert xylose to xylulose, although non-engineered strains cannot proliferate on xylose as the sole carbon source." @default.
• W2078366840 created "2016-06-24" @default.
• W2078366840 creator A5000249682 @default.
• W2078366840 creator A5012961839 @default.
• W2078366840 creator A5015053442 @default.
• W2078366840 creator A5043193388 @default.
• W2078366840 creator A5059796808 @default.
• W2078366840 creator A5076154224 @default.
• W2078366840 creator A5086985620 @default.
• W2078366840 date "2013-11-13" @default.
• W2078366840 modified "2023-10-01" @default.
• W2078366840 title "Comparative Xylose Metabolism among the Ascomycetes C. albicans, S. stipitis and S. cerevisiae" @default.
• W2078366840 cites W1559650160 @default.
• W2078366840 cites W1726118231 @default.
• W2078366840 cites W1970871100 @default.
• W2078366840 cites W1973410051 @default.
• W2078366840 cites W1975589683 @default.
• W2078366840 cites W1980595120 @default.
• W2078366840 cites W1986207589 @default.
• W2078366840 cites W1986494359 @default.
• W2078366840 cites W1989978741 @default.
• W2078366840 cites W1990474165 @default.
• W2078366840 cites W1995754833 @default.
• W2078366840 cites W2010715850 @default.
• W2078366840 cites W2015012952 @default.
• W2078366840 cites W2052579446 @default.
• W2078366840 cites W2053837262 @default.
• W2078366840 cites W2060721894 @default.
• W2078366840 cites W2068003115 @default.
• W2078366840 cites W2084737875 @default.
• W2078366840 cites W2095209321 @default.
• W2078366840 cites W2096202610 @default.
• W2078366840 cites W2112615705 @default.
• W2078366840 cites W2119507799 @default.
• W2078366840 cites W2122577863 @default.
• W2078366840 cites W2128207311 @default.
• W2078366840 cites W2128941915 @default.
• W2078366840 cites W2130769450 @default.
• W2078366840 cites W2134814258 @default.
• W2078366840 cites W2146503498 @default.
• W2078366840 cites W2147913192 @default.
• W2078366840 cites W2153504900 @default.
• W2078366840 cites W2162706722 @default.
• W2078366840 cites W2165286188 @default.
• W2078366840 cites W2165587207 @default.
• W2078366840 cites W2165668000 @default.
• W2078366840 cites W2283280950 @default.
• W2078366840 cites W3188915507 @default.
• W2078366840 doi "https://doi.org/10.1371/journal.pone.0080733" @default.
• W2078366840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3827475" @default.
• W2078366840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24236198" @default.
• W2078366840 hasPublicationYear "2013" @default.
• W2078366840 type Work @default.
• W2078366840 sameAs 2078366840 @default.
• W2078366840 citedByCount "15" @default.
• W2078366840 countsByYear W20783668402014 @default.
• W2078366840 countsByYear W20783668402015 @default.
• W2078366840 countsByYear W20783668402016 @default.
• W2078366840 countsByYear W20783668402017 @default.
• W2078366840 countsByYear W20783668402019 @default.
• W2078366840 countsByYear W20783668402021 @default.
• W2078366840 countsByYear W20783668402022 @default.
• W2078366840 countsByYear W20783668402023 @default.
• W2078366840 crossrefType "journal-article" @default.
• W2078366840 hasAuthorship W2078366840A5000249682 @default.
• W2078366840 hasAuthorship W2078366840A5012961839 @default.
• W2078366840 hasAuthorship W2078366840A5015053442 @default.
• W2078366840 hasAuthorship W2078366840A5043193388 @default.
• W2078366840 hasAuthorship W2078366840A5059796808 @default.
• W2078366840 hasAuthorship W2078366840A5076154224 @default.
• W2078366840 hasAuthorship W2078366840A5086985620 @default.
• W2078366840 hasBestOaLocation W20783668401 @default.
• W2078366840 hasConcept C100544194 @default.
• W2078366840 hasConcept C104317684 @default.
• W2078366840 hasConcept C143065580 @default.
• W2078366840 hasConcept C2776031079 @default.
• W2078366840 hasConcept C2777576037 @default.
• W2078366840 hasConcept C2777809033 @default.
• W2078366840 hasConcept C2779222958 @default.
• W2078366840 hasConcept C2779277513 @default.
• W2078366840 hasConcept C2780294150 @default.
• W2078366840 hasConcept C2780917455 @default.
• W2078366840 hasConcept C2781135521 @default.
• W2078366840 hasConcept C55493867 @default.
• W2078366840 hasConcept C86803240 @default.
• W2078366840 hasConcept C89423630 @default.
• W2078366840 hasConceptScore W2078366840C100544194 @default.
• W2078366840 hasConceptScore W2078366840C104317684 @default.
• W2078366840 hasConceptScore W2078366840C143065580 @default.
• W2078366840 hasConceptScore W2078366840C2776031079 @default.
• W2078366840 hasConceptScore W2078366840C2777576037 @default.
• W2078366840 hasConceptScore W2078366840C2777809033 @default.
• W2078366840 hasConceptScore W2078366840C2779222958 @default.
• W2078366840 hasConceptScore W2078366840C2779277513 @default.
• W2078366840 hasConceptScore W2078366840C2780294150 @default.
• W2078366840 hasConceptScore W2078366840C2780917455 @default.
• W2078366840 hasConceptScore W2078366840C2781135521 @default.
• W2078366840 hasConceptScore W2078366840C55493867 @default.

• next