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- W2078369142 abstract "Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration. We have measured, in the rat, hepatic uptake of a ricin A chain antibody conjugate invivo and its susceptibility to inhibition by a mannosylated protein and have measured uptake of the conjugate invitro by rat parenchymal and non-parenchymal liver cells. The results indicate that rapid hepatic uptake of conjugate does occur invivo; cultured non-parenchymal cells accumulate the conjugate to a much greater degree than cultured parenchymal cells and that mannose receptors appear to be involved in the process." @default.
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- W2078369142 date "1986-06-01" @default.
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- W2078369142 title "Mannose receptor dependent uptake of a ricin a chain - antibody conjugate by rat liver non-parenchymal cells" @default.
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- W2078369142 doi "https://doi.org/10.1016/0006-291x(86)91163-0" @default.
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