FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078369332> ?p ?o ?g. }

• W2078369332 abstract "Abstract Background Poultry meat is one of the most important sources of human campylobacteriosis, an acute bacterial enteritis which is a major problem worldwide. Campylobacter coli and Campylobacter jejuni are the most common Campylobacter species associated with this disease. These pathogens live in the intestinal tract of most avian species and under commercial conditions they spread rapidly to infect a high proportion of the flock, which makes their treatment and prevention very difficult. Bacteriophages (phages) are naturally occurring predators of bacteria with high specificity and also the capacity to evolve to overcome bacterial resistance. Therefore phage therapy is a promising alternative to antibiotics in animal production. This study tested the efficacy of a phage cocktail composed of three phages for the control of poultry infected with C. coli and C. jejuni . Moreover, it evaluated the effectiveness of two routes of phage administration (by oral gavage and in feed) in order to provide additional information regarding their future use in a poultry unit. Results The results indicate that experimental colonisation of chicks was successful and that the birds showed no signs of disease even at the highest dose of Campylobacter administered. The phage cocktail was able to reduce the titre of both C. coli and C. jejuni in faeces by approximately 2 log 10 cfu/g when administered by oral gavage and in feed. This reduction persisted throughout the experimental period and neither pathogen regained their former numbers. The reduction in Campylobacter titre was achieved earlier (2 days post-phage administration) when the phage cocktail was incorporated in the birds' feed. Campylobacter strains resistant to phage infection were recovered from phage-treated chickens at a frequency of 13%. These resistant phenotypes did not exhibit a reduced ability to colonize the chicken guts and did not revert to sensitive types. Conclusions Our findings provide further evidence of the efficacy of phage therapy for the control of Campylobacter in poultry. The broad host range of the novel phage cocktail enabled it to target both C. jejuni and C. coli strains. Moreover the reduction of Campylobacter by approximately 2 log 10 cfu/g, as occurred in our study, could lead to a 30-fold reduction in the incidence of campylobacteriosis associated with consumption of chicken meals (according to mathematical models). To our knowledge this is the first report of phage being administered in feed to Campylobacter- infected chicks and our results show that it lead to an earlier and more sustainable reduction of Campylobacter than administration by oral gavage. Therefore the present study is of extreme importance as it has shown that administering phages to poultry via the food could be successful on a commercial scale." @default.
• W2078369332 created "2016-06-24" @default.
• W2078369332 creator A5007825339 @default.
• W2078369332 creator A5012614394 @default.
• W2078369332 creator A5013532225 @default.
• W2078369332 creator A5029481092 @default.
• W2078369332 creator A5071306942 @default.
• W2078369332 creator A5075474631 @default.
• W2078369332 creator A5091348599 @default.
• W2078369332 date "2010-09-01" @default.
• W2078369332 modified "2023-10-02" @default.
• W2078369332 title "The in vivo efficacy of two administration routes of a phage cocktail to reduce numbers of Campylobacter coli and Campylobacter jejuni in chickens" @default.
• W2078369332 cites W1550682512 @default.
• W2078369332 cites W1590700741 @default.
• W2078369332 cites W1947108769 @default.
• W2078369332 cites W1964946523 @default.
• W2078369332 cites W196513295 @default.
• W2078369332 cites W1974936597 @default.
• W2078369332 cites W1975401661 @default.
• W2078369332 cites W1975706130 @default.
• W2078369332 cites W1975884269 @default.
• W2078369332 cites W2006896063 @default.
• W2078369332 cites W2018819380 @default.
• W2078369332 cites W2019197162 @default.
• W2078369332 cites W2021115141 @default.
• W2078369332 cites W2024142244 @default.
• W2078369332 cites W2029624199 @default.
• W2078369332 cites W2036065279 @default.
• W2078369332 cites W2050998488 @default.
• W2078369332 cites W2066141393 @default.
• W2078369332 cites W2088214124 @default.
• W2078369332 cites W2093393891 @default.
• W2078369332 cites W2095557713 @default.
• W2078369332 cites W2100229346 @default.
• W2078369332 cites W2103301499 @default.
• W2078369332 cites W2103814293 @default.
• W2078369332 cites W2113625817 @default.
• W2078369332 cites W2113855069 @default.
• W2078369332 cites W2119030598 @default.
• W2078369332 cites W2127874065 @default.
• W2078369332 cites W2129217207 @default.
• W2078369332 cites W2131517665 @default.
• W2078369332 cites W2132954220 @default.
• W2078369332 cites W2139745617 @default.
• W2078369332 cites W2142058155 @default.
• W2078369332 cites W2145634571 @default.
• W2078369332 cites W2151587656 @default.
• W2078369332 cites W2152005348 @default.
• W2078369332 cites W2156962949 @default.
• W2078369332 cites W2158284941 @default.
• W2078369332 cites W2160833308 @default.
• W2078369332 cites W2168183407 @default.
• W2078369332 cites W2184320396 @default.
• W2078369332 cites W2420215847 @default.
• W2078369332 cites W4255578408 @default.
• W2078369332 cites W4322700637 @default.
• W2078369332 doi "https://doi.org/10.1186/1471-2180-10-232" @default.
• W2078369332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2940857" @default.
• W2078369332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20809975" @default.
• W2078369332 hasPublicationYear "2010" @default.
• W2078369332 type Work @default.
• W2078369332 sameAs 2078369332 @default.
• W2078369332 citedByCount "170" @default.
• W2078369332 countsByYear W20783693322012 @default.
• W2078369332 countsByYear W20783693322013 @default.
• W2078369332 countsByYear W20783693322014 @default.
• W2078369332 countsByYear W20783693322015 @default.
• W2078369332 countsByYear W20783693322016 @default.
• W2078369332 countsByYear W20783693322017 @default.
• W2078369332 countsByYear W20783693322018 @default.
• W2078369332 countsByYear W20783693322019 @default.
• W2078369332 countsByYear W20783693322020 @default.
• W2078369332 countsByYear W20783693322021 @default.
• W2078369332 countsByYear W20783693322022 @default.
• W2078369332 countsByYear W20783693322023 @default.
• W2078369332 crossrefType "journal-article" @default.
• W2078369332 hasAuthorship W2078369332A5007825339 @default.
• W2078369332 hasAuthorship W2078369332A5012614394 @default.
• W2078369332 hasAuthorship W2078369332A5013532225 @default.
• W2078369332 hasAuthorship W2078369332A5029481092 @default.
• W2078369332 hasAuthorship W2078369332A5071306942 @default.
• W2078369332 hasAuthorship W2078369332A5075474631 @default.
• W2078369332 hasAuthorship W2078369332A5091348599 @default.
• W2078369332 hasBestOaLocation W20783693321 @default.
• W2078369332 hasConcept C104317684 @default.
• W2078369332 hasConcept C134215735 @default.
• W2078369332 hasConcept C151730666 @default.
• W2078369332 hasConcept C2776441376 @default.
• W2078369332 hasConcept C2776957140 @default.
• W2078369332 hasConcept C2777403496 @default.
• W2078369332 hasConcept C2777858656 @default.
• W2078369332 hasConcept C2779256223 @default.
• W2078369332 hasConcept C2779910956 @default.
• W2078369332 hasConcept C2780031333 @default.
• W2078369332 hasConcept C501593827 @default.
• W2078369332 hasConcept C523546767 @default.
• W2078369332 hasConcept C54355233 @default.
• W2078369332 hasConcept C547475151 @default.
• W2078369332 hasConcept C55493867 @default.
• W2078369332 hasConcept C61716771 @default.

• next