FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078369343> ?p ?o ?g. }

• W2078369343 endingPage "143" @default.
• W2078369343 startingPage "136" @default.
• W2078369343 abstract "Because oxidative processes can participate in tumor promotion, it is likely that the cellular antioxidant defense also plays a role. We have compared the levels of the three major antioxidant enzymes, Cu,Zn-superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx), in promotable mouse epidermal JB6 cells clone 41 and nonpromotable cells, clone 30. We found that the constitutive activities of SOD and catalase were approximately twice as high in clone 41 as in clone 30 while the GPx activities were comparable. Correspondingly, catalase protein concentrations were higher in clone 41, according to immunoblots. Northern blot analysis indicated that the steady-state mRNA concentrations for SOD and catalase, but not for GPx, were considerably higher in clone 41 than in clone 30. Southern blot analysis showed no difference between the two clones in their complements of the SOD and catalase genes. Clone 41 also contained slightly higher constitutive levels of glutathione. The higher antioxidant capacity of promotable clone 41 may protect it from excessive toxicity of oxidant promoters and allow growth stimulation. Certain tumor promoters that lack oxidizing properties may generate a cellular prooxidant state by a variety of mechanisms (e.g., it had been reported that the phorbol ester PMA decreases the activities of catalase and SOD in mouse skin). We found for JB6 cells that this loss of enzyme activity was due to a decrease in the steady-state concentrations of catalase and SOD mRNA. No significant changes in the rates of transcription were detected in nuclear run-off experiments. The observed decreases in catalase and SOD can be considered as part of the complex reprogramming of gene expression that is set in motion by phorbol-12-myristate-13-acetate." @default.
• W2078369343 created "2016-06-24" @default.
• W2078369343 creator A5004119367 @default.
• W2078369343 creator A5016879734 @default.
• W2078369343 creator A5045345578 @default.
• W2078369343 creator A5063856596 @default.
• W2078369343 date "1989-01-01" @default.
• W2078369343 modified "2023-10-16" @default.
• W2078369343 title "Constitutive and phorbol-myristate-acetate regulated antioxidant defense of mouse epidermal JB6 cells" @default.
• W2078369343 cites W1481433938 @default.
• W2078369343 cites W1516659005 @default.
• W2078369343 cites W1577366889 @default.
• W2078369343 cites W1976363596 @default.
• W2078369343 cites W1984373476 @default.
• W2078369343 cites W1988186940 @default.
• W2078369343 cites W2010847254 @default.
• W2078369343 cites W2018823412 @default.
• W2078369343 cites W2035706724 @default.
• W2078369343 cites W2039865438 @default.
• W2078369343 cites W204358047 @default.
• W2078369343 cites W2051819610 @default.
• W2078369343 cites W2060817649 @default.
• W2078369343 cites W2063450941 @default.
• W2078369343 cites W2076044062 @default.
• W2078369343 cites W2078119356 @default.
• W2078369343 cites W2083351444 @default.
• W2078369343 cites W2088039859 @default.
• W2078369343 cites W2090580979 @default.
• W2078369343 cites W2100633713 @default.
• W2078369343 cites W2100837269 @default.
• W2078369343 cites W2102131116 @default.
• W2078369343 cites W2113008499 @default.
• W2078369343 cites W2137256427 @default.
• W2078369343 cites W2145059527 @default.
• W2078369343 cites W2154109712 @default.
• W2078369343 cites W2160487932 @default.
• W2078369343 cites W2163651437 @default.
• W2078369343 cites W2195614113 @default.
• W2078369343 cites W4229493460 @default.
• W2078369343 doi "https://doi.org/10.1002/mc.2940020306" @default.
• W2078369343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2789690" @default.
• W2078369343 hasPublicationYear "1989" @default.
• W2078369343 type Work @default.
• W2078369343 sameAs 2078369343 @default.
• W2078369343 citedByCount "22" @default.
• W2078369343 countsByYear W20783693432013 @default.
• W2078369343 countsByYear W20783693432014 @default.
• W2078369343 countsByYear W20783693432021 @default.
• W2078369343 crossrefType "journal-article" @default.
• W2078369343 hasAuthorship W2078369343A5004119367 @default.
• W2078369343 hasAuthorship W2078369343A5016879734 @default.
• W2078369343 hasAuthorship W2078369343A5045345578 @default.
• W2078369343 hasAuthorship W2078369343A5063856596 @default.
• W2078369343 hasConcept C104317684 @default.
• W2078369343 hasConcept C105580179 @default.
• W2078369343 hasConcept C153911025 @default.
• W2078369343 hasConcept C177707886 @default.
• W2078369343 hasConcept C203663253 @default.
• W2078369343 hasConcept C2775838275 @default.
• W2078369343 hasConcept C2776415932 @default.
• W2078369343 hasConcept C2778004101 @default.
• W2078369343 hasConcept C2778760513 @default.
• W2078369343 hasConcept C2778979269 @default.
• W2078369343 hasConcept C55493867 @default.
• W2078369343 hasConcept C81089528 @default.
• W2078369343 hasConcept C86803240 @default.
• W2078369343 hasConceptScore W2078369343C104317684 @default.
• W2078369343 hasConceptScore W2078369343C105580179 @default.
• W2078369343 hasConceptScore W2078369343C153911025 @default.
• W2078369343 hasConceptScore W2078369343C177707886 @default.
• W2078369343 hasConceptScore W2078369343C203663253 @default.
• W2078369343 hasConceptScore W2078369343C2775838275 @default.
• W2078369343 hasConceptScore W2078369343C2776415932 @default.
• W2078369343 hasConceptScore W2078369343C2778004101 @default.
• W2078369343 hasConceptScore W2078369343C2778760513 @default.
• W2078369343 hasConceptScore W2078369343C2778979269 @default.
• W2078369343 hasConceptScore W2078369343C55493867 @default.
• W2078369343 hasConceptScore W2078369343C81089528 @default.
• W2078369343 hasConceptScore W2078369343C86803240 @default.
• W2078369343 hasIssue "3" @default.
• W2078369343 hasLocation W20783693431 @default.
• W2078369343 hasLocation W20783693432 @default.
• W2078369343 hasOpenAccess W2078369343 @default.
• W2078369343 hasPrimaryLocation W20783693431 @default.
• W2078369343 hasRelatedWork W12268215 @default.
• W2078369343 hasRelatedWork W2074687883 @default.
• W2078369343 hasRelatedWork W2078369343 @default.
• W2078369343 hasRelatedWork W2080826922 @default.
• W2078369343 hasRelatedWork W2136100804 @default.
• W2078369343 hasRelatedWork W2266595138 @default.
• W2078369343 hasRelatedWork W2294370795 @default.
• W2078369343 hasRelatedWork W2378549182 @default.
• W2078369343 hasRelatedWork W2898254423 @default.
• W2078369343 hasRelatedWork W3214998341 @default.
• W2078369343 hasVolume "2" @default.
• W2078369343 isParatext "false" @default.
• W2078369343 isRetracted "false" @default.
• W2078369343 magId "2078369343" @default.

• next