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- W2078369364 abstract "Myoblast cultures from normal and Tg-MDA (transgenic mouse overexpressing dystrophin 50-fold) mice were transplanted into dystrophin-deficient mdx mouse muscles. Four weeks after transplantation, dystrophin-positive fibers were observed four times more frequently in cross sections of muscles injected with Tg-MDA. Myoblasts from Tg-MDA mice also expressing the β-gal transgene (Tg-MDA/β-gal) and myoblasts from β-gal transgenic mice containing one normal dystrophin gene (normal/β-gal) were also transplanted into mdx mouse muscles. Four weeks after transplantation, the fiber length positive for dystrophin (nuclear domain) was shorter (439 ± 326 μm) than the β-gal nuclear domain (1466 ± 713 μm) of the same fiber when normal/β-gal myoblasts were transplanted, but increased (1302 ± 487 μm) when Tg-MDA/β-gal myoblasts were used. These experiments show that despite the presence in Tg-MDA myoblasts of constructions which lead in vivo in transgenic mice to an overexpression of dystrophin 50-fold, the membrane area over which dystrophin was expressed was increased only threefold. This observation is also expected for vector-mediated gene therapy. © 1998 John Wiley & Sons, Inc. Muscle Nerve, 21: 91–103, 1998." @default.
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- W2078369364 date "1998-01-01" @default.
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- W2078369364 title "Transplantation of myoblasts from a transgenic mouse overexpressing dystrophin produced only a relatively small increase of dystrophin-positive membrane" @default.
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- W2078369364 doi "https://doi.org/10.1002/(sici)1097-4598(199801)21:1<91::aid-mus12>3.0.co;2-3" @default.
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