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- W2078370240 abstract "Introduction: Chronic vascular inflammation plays a decisive role in atherosclerosis, and through its markers we can foretell this injure. The blockage of AT1 receptors could slow down the process. Third generation calcium channels blockers, more lipophilic, have also demonstrated an antioxidant effect. Objective: Analysing the results of Olmesartan (angiotensine II AT1 receptor blocker) and Lercanidipine (third generation calcium channel blockers) over inflammatory vascular biomarkers. Patients and Method: 82 patients were included. They were measured classic inflammation markers (ESR, leucocytes, fibrinogen) and emergent ones (CPR, IL-6, alpha TNF, homocysteine); both at the beginning and after 16 weeks of treatment. The statistic analysis was carried out through SPSS 13.0 for Windows, and p < 0,05 was considered as significant. Results and Conclusions: Classic markers were not statistically significant in comparison with the emergent markers. Lercanidipine did not affect significantly the levels of IL6, alpha TNF or homocysteine; probably, because it did not act over inflammatory cytokines. However, Olmesartan reduced IL-6, alpha TNF and homocysteine levels after treatment. This effect seems to be independent from blood pressure drop, most likely due to the blockage of angiotensine II action. IL-6 basal values were markedly diminished in the Olmesartan group (from 33,43 ± 27,4 pg/ml to 13,81 ± 20,27 pg/ml), as well as those of homocysteine (from 11,00 ± 7,8 umol/l to 9,62 ± 5,4 umol/l). This effect has not been observed in other renine angiotensine II blockers." @default.
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- W2078370240 date "2010-06-01" @default.
- W2078370240 modified "2023-10-14" @default.
- W2078370240 title "CHANGES OF VASCULAR INFLAMMATORY MARKERS IN A GROUP OF PATIENTS AFTER 16 WEEKS OF ANTIHYPERTENSIVE TREATMENT: PP.33.326" @default.
- W2078370240 doi "https://doi.org/10.1097/01.hjh.0000379864.37169.cf" @default.
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