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• W2078377639 endingPage "e40949" @default.
• W2078377639 startingPage "e40949" @default.
• W2078377639 abstract "A glycolytic profile unifies a group of pheochromocytomas and paragangliomas (PHEOs/PGLs) with distinct underlying gene defects, including von Hippel-Lindau (VHL) and succinate dehydrogenase B (SDHB) mutations. Nevertheless, their tumor aggressiveness is distinct: PHEOs/PGLs metastasize rarely in VHL-, but frequently in SDHB-patients. To date, the molecular mechanisms causing the more aggressive phenotype in SDHB-PHEOs/PGLs remain largely unknown. Recently, however, an excellent model to study aggressive PHEOs (mouse tumor tissue (MTT) cells) has been developed from mouse PHEO cells (MPC). We employed this model for a proteomics based approach to identify changes characteristic for tumor aggressiveness, which we then explored in a homogeneous set of human SDHB- and VHL-PHEOs/PGLs. The increase of glucose transporter 1 in VHL, and of hexokinase 2 in VHL and SDHB, confirmed their glycolytic profile. In agreement with the cell model and in support of decoupling of glycolysis, the Krebs cycle and oxidative phosphorylation (OXPHOS), SDHB tumors showed increased lactate dehydrogenase levels. In SDHB-PGLs OXPHOS complex activity was increased at complex III and, as expected, decreased at complex II. Moreover, protein and mRNA expression of all tested OXPHOS-related genes were higher in SDHB- than in VHL-derived tumors. Although there was no direct evidence for increased reactive oxygen species production, elevated superoxide dismutase 2 expression may reflect elevated oxidative stress in SDHB-derived PHEOs/PGLs. For the first time, we show that despite dysfunction in complex II and evidence for a glycolytic phenotype, the Warburg effect does not seem to fully apply to SDHB-PHEOs/PGLs with respect to decreased OXPHOS. In addition, we present evidence for increased LDHA and SOD2 expression in SDHB-PHEOs/PGLs, proteins that have been proposed as promising therapeutic targets in other cancers. This study provides new insight into pathogenic mechanisms in aggressive human PHEOs/PGLs, which may lead to identifying new diagnostic and prognostic markers in the near future." @default.
• W2078377639 created "2016-06-24" @default.
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• W2078377639 date "2012-07-31" @default.
• W2078377639 modified "2023-10-16" @default.
• W2078377639 title "Warburg Effect’s Manifestation in Aggressive Pheochromocytomas and Paragangliomas: Insights from a Mouse Cell Model Applied to Human Tumor Tissue" @default.
• W2078377639 cites W1528834211 @default.
• W2078377639 cites W1749022239 @default.
• W2078377639 cites W1851247610 @default.
• W2078377639 cites W1963605476 @default.
• W2078377639 cites W1971403257 @default.
• W2078377639 cites W1975419073 @default.
• W2078377639 cites W1975918337 @default.
• W2078377639 cites W1978916986 @default.
• W2078377639 cites W1981593008 @default.
• W2078377639 cites W1984501829 @default.
• W2078377639 cites W1985010769 @default.
• W2078377639 cites W1985384678 @default.
• W2078377639 cites W1987611065 @default.
• W2078377639 cites W1994364558 @default.
• W2078377639 cites W1997076510 @default.
• W2078377639 cites W2004297810 @default.
• W2078377639 cites W2004787400 @default.
• W2078377639 cites W2014318015 @default.
• W2078377639 cites W2015556811 @default.
• W2078377639 cites W2018761889 @default.
• W2078377639 cites W2019042812 @default.
• W2078377639 cites W2022101765 @default.
• W2078377639 cites W2025719835 @default.
• W2078377639 cites W2035515157 @default.
• W2078377639 cites W2036676122 @default.
• W2078377639 cites W2038009564 @default.
• W2078377639 cites W2046687522 @default.
• W2078377639 cites W2050140657 @default.
• W2078377639 cites W2059391512 @default.
• W2078377639 cites W2060490290 @default.
• W2078377639 cites W2063687158 @default.
• W2078377639 cites W2071143412 @default.
• W2078377639 cites W2071716768 @default.
• W2078377639 cites W2078684128 @default.
• W2078377639 cites W2083814145 @default.
• W2078377639 cites W2084603737 @default.
• W2078377639 cites W2084942892 @default.
• W2078377639 cites W2087680149 @default.
• W2078377639 cites W2091083505 @default.
• W2078377639 cites W2093776019 @default.
• W2078377639 cites W2096404967 @default.
• W2078377639 cites W2098189012 @default.
• W2078377639 cites W2103306705 @default.
• W2078377639 cites W2107911729 @default.
• W2078377639 cites W2110251906 @default.
• W2078377639 cites W2112078820 @default.
• W2078377639 cites W2112521850 @default.
• W2078377639 cites W2119169141 @default.
• W2078377639 cites W2119235043 @default.
• W2078377639 cites W2119924624 @default.
• W2078377639 cites W2122816851 @default.
• W2078377639 cites W2126511952 @default.
• W2078377639 cites W2128410150 @default.
• W2078377639 cites W2130503287 @default.
• W2078377639 cites W2134772236 @default.
• W2078377639 cites W2136543787 @default.
• W2078377639 cites W2136749294 @default.
• W2078377639 cites W2138605089 @default.
• W2078377639 cites W2142717876 @default.
• W2078377639 cites W2142765712 @default.
• W2078377639 cites W2144878030 @default.
• W2078377639 cites W2149282639 @default.
• W2078377639 cites W2155436129 @default.
• W2078377639 cites W2155895139 @default.
• W2078377639 cites W2159194061 @default.
• W2078377639 cites W2163471981 @default.
• W2078377639 cites W2163578961 @default.
• W2078377639 cites W33354229 @default.
• W2078377639 cites W657549198 @default.
• W2078377639 cites W87977805 @default.
• W2078377639 doi "https://doi.org/10.1371/journal.pone.0040949" @default.
• W2078377639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3409208" @default.
• W2078377639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22859959" @default.

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