Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078377706> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2078377706 endingPage "506" @default.
- W2078377706 startingPage "498" @default.
- W2078377706 abstract "Licorice root has been used for years to regulate gastrointestinal function in traditional Chinese medicine. This study reveals the gastrointestinal effects of isoliquiritigenin, a flavonoid isolated from the roots of Glycyrrhiza glabra (a kind of Licorice). In vivo, isoliquiritigenin produced a dual dose-related effect on the charcoal meal travel, inhibitory at the low doses, while prokinetic at the high doses. In vitro, isoliquiritigenin showed an atropine-sensitive concentration-dependent spasmogenic effect in isolated rat stomach fundus. However, a spasmolytic effect was observed in isolated rabbit jejunums, guinea pig ileums and atropinized rat stomach fundus, either as noncompetitive inhibition of agonist concentration-response curves, inhibition of high K+ (80 mM)-induced contractions, or displacement of Ca2+ concentration-response curves to the right, indicating a calcium antagonist effect. Pretreatment with Nω-nitro-L-arginine methyl ester (L-NAME; 30 µM), indomethacin (10 µM), methylene blue (10 µM), tetraethylammonium chloride (0.5 mM), glibenclamide (1 µM), 4-aminopyridine (0.1 mM), or clotrimazole (1 µM) did not inhibit the spasmolytic effect. These results indicate that isoliquiritigenin plays a dual role in regulating gastrointestinal motility, both spasmogenic and spasmolytic. The spasmogenic effect may involve the activating of muscarinic receptors, while the spasmolytic effect is predominantly due to blockade of the calcium channels. Copyright © 2008 John Wiley & Sons, Ltd." @default.
- W2078377706 created "2016-06-24" @default.
- W2078377706 creator A5015897349 @default.
- W2078377706 creator A5022499603 @default.
- W2078377706 creator A5042786497 @default.
- W2078377706 creator A5045067652 @default.
- W2078377706 creator A5068881715 @default.
- W2078377706 creator A5089300427 @default.
- W2078377706 date "2009-04-01" @default.
- W2078377706 modified "2023-09-30" @default.
- W2078377706 title "Isoliquiritigenin, a flavonoid from licorice, plays a dual role in regulating gastrointestinal motility<i>in vitro</i>and<i>in vivo</i>" @default.
- W2078377706 cites W1912176475 @default.
- W2078377706 cites W1968598815 @default.
- W2078377706 cites W1974331236 @default.
- W2078377706 cites W1979750411 @default.
- W2078377706 cites W1983948790 @default.
- W2078377706 cites W1987367266 @default.
- W2078377706 cites W1988590403 @default.
- W2078377706 cites W1991645386 @default.
- W2078377706 cites W2010822856 @default.
- W2078377706 cites W2011415671 @default.
- W2078377706 cites W2017523142 @default.
- W2078377706 cites W2018913233 @default.
- W2078377706 cites W2021367406 @default.
- W2078377706 cites W2029594829 @default.
- W2078377706 cites W2035605859 @default.
- W2078377706 cites W2038462428 @default.
- W2078377706 cites W2046860123 @default.
- W2078377706 cites W2057090386 @default.
- W2078377706 cites W2059027090 @default.
- W2078377706 cites W2087783979 @default.
- W2078377706 cites W2091027628 @default.
- W2078377706 cites W2094501952 @default.
- W2078377706 cites W2102190450 @default.
- W2078377706 cites W2107351349 @default.
- W2078377706 cites W2170958988 @default.
- W2078377706 cites W2321330457 @default.
- W2078377706 cites W2335757080 @default.
- W2078377706 cites W4248230737 @default.
- W2078377706 doi "https://doi.org/10.1002/ptr.2660" @default.
- W2078377706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19067384" @default.
- W2078377706 hasPublicationYear "2009" @default.
- W2078377706 type Work @default.
- W2078377706 sameAs 2078377706 @default.
- W2078377706 citedByCount "59" @default.
- W2078377706 countsByYear W20783777062012 @default.
- W2078377706 countsByYear W20783777062013 @default.
- W2078377706 countsByYear W20783777062014 @default.
- W2078377706 countsByYear W20783777062015 @default.
- W2078377706 countsByYear W20783777062016 @default.
- W2078377706 countsByYear W20783777062017 @default.
- W2078377706 countsByYear W20783777062018 @default.
- W2078377706 countsByYear W20783777062019 @default.
- W2078377706 countsByYear W20783777062020 @default.
- W2078377706 countsByYear W20783777062021 @default.
- W2078377706 countsByYear W20783777062022 @default.
- W2078377706 countsByYear W20783777062023 @default.
- W2078377706 crossrefType "journal-article" @default.
- W2078377706 hasAuthorship W2078377706A5015897349 @default.
- W2078377706 hasAuthorship W2078377706A5022499603 @default.
- W2078377706 hasAuthorship W2078377706A5042786497 @default.
- W2078377706 hasAuthorship W2078377706A5045067652 @default.
- W2078377706 hasAuthorship W2078377706A5068881715 @default.
- W2078377706 hasAuthorship W2078377706A5089300427 @default.
- W2078377706 hasConcept C185592680 @default.
- W2078377706 hasConcept C2776974645 @default.
- W2078377706 hasConcept C556039675 @default.
- W2078377706 hasConcept C71924100 @default.
- W2078377706 hasConcept C98274493 @default.
- W2078377706 hasConceptScore W2078377706C185592680 @default.
- W2078377706 hasConceptScore W2078377706C2776974645 @default.
- W2078377706 hasConceptScore W2078377706C556039675 @default.
- W2078377706 hasConceptScore W2078377706C71924100 @default.
- W2078377706 hasConceptScore W2078377706C98274493 @default.
- W2078377706 hasIssue "4" @default.
- W2078377706 hasLocation W20783777061 @default.
- W2078377706 hasLocation W20783777062 @default.
- W2078377706 hasOpenAccess W2078377706 @default.
- W2078377706 hasPrimaryLocation W20783777061 @default.
- W2078377706 hasRelatedWork W1496133404 @default.
- W2078377706 hasRelatedWork W2042963739 @default.
- W2078377706 hasRelatedWork W2058135376 @default.
- W2078377706 hasRelatedWork W2312738036 @default.
- W2078377706 hasRelatedWork W2328204832 @default.
- W2078377706 hasRelatedWork W2407003119 @default.
- W2078377706 hasRelatedWork W2906943159 @default.
- W2078377706 hasRelatedWork W3007274587 @default.
- W2078377706 hasRelatedWork W3188519079 @default.
- W2078377706 hasRelatedWork W4213352704 @default.
- W2078377706 hasVolume "23" @default.
- W2078377706 isParatext "false" @default.
- W2078377706 isRetracted "false" @default.
- W2078377706 magId "2078377706" @default.
- W2078377706 workType "article" @default.