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- W2078378191 abstract "This article reviews current approaches to defining clinically meaningful change in health-related quality of life (HRQOL) and provides guidelines for their use. Definitions of clinically meaningful change are discussed. Two broad methods for identifying clinically meaningful change are contrasted: anchor-based methods and distribution-based methods. Anchor-based methods include cross-sectional approaches and longitudinal approaches. Distribution-based methods include those based on statistical significance, sample variability, and measurement precision. Anchor-based and distribution-based methods have advantages and limitations, and neither seems to be superior to the other. An integrated system for defining clinically meaningful change is recommended that combines anchor-based and distribution-based methods. We propose a new terminology for describing meaningful change derived from anchor-based and distribution-based methods." @default.
- W2078378191 created "2016-06-24" @default.
- W2078378191 creator A5009834928 @default.
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- W2078378191 date "2003-05-01" @default.
- W2078378191 modified "2023-10-17" @default.
- W2078378191 title "Defining clinically meaningful change in health-related quality of life" @default.
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- W2078378191 doi "https://doi.org/10.1016/s0895-4356(03)00044-1" @default.
- W2078378191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12812812" @default.
- W2078378191 hasPublicationYear "2003" @default.
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