FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078382040> ?p ?o ?g. }

• W2078382040 endingPage "886" @default.
• W2078382040 startingPage "873" @default.
• W2078382040 abstract "We investigated the spatio-temporal profile of hemoglobin subunit expression in developing avascular tissues. Significant up-regulation of hemoglobin subunits was identified in microarray experiments comparing blastocyst inner cell masses with undifferentiated embryonic stem (ES) cells. Hemoglobin expression changes were confirmed using embryoid bodies (derived from <i>in vitro</i> differentiation of ES cells) to model very early development at pre-vascular stages of embryogenesis; i.e. prior to hematopoiesis. We also demonstrate, using RT-PCR, Western blotting and immunocytochemistry, expression of adult and fetal mouse hemoglobin subunits in the avascular ocular lens at various stages of development and maturation. Hemoglobin proteins were expressed in lens epithelial cells (cytoplasmic) and cortical lens fiber cells (nuclear and cell-surface-associated); however, a sensitive heme assay demonstrated negligible levels of heme in the developing lens postnatally. Hemoglobin expression was also observed in the developing eye in corneal endothelium and retinal ganglion cells. Gut sections showed, in addition to erythrocytes, hemoglobin protein staining in rare, individual villus epithelial cells. These results suggest a paradigm shift: hemoglobin subunits are expressed in the avascular lens and cornea and in pre-hematopoietic embryos. It is likely, therefore, that hemoglobin subunits have novel developmental roles; the absence of the heme group from the lens would indicate that at least some of these functions may be independent of oxygen metabolism. The pattern of expression of hemoglobin subunits in the perinuclear region during lens fiber cell differentiation, when denucleation is taking place, may indicate involvement in the apoptosis-like signaling processes occurring in differentiating lens fiber cells." @default.
• W2078382040 created "2016-06-24" @default.
• W2078382040 creator A5005293866 @default.
• W2078382040 creator A5005686833 @default.
• W2078382040 creator A5015814792 @default.
• W2078382040 creator A5024851123 @default.
• W2078382040 creator A5040517975 @default.
• W2078382040 creator A5041975628 @default.
• W2078382040 creator A5089983912 @default.
• W2078382040 date "2008-01-01" @default.
• W2078382040 modified "2023-10-01" @default.
• W2078382040 title "Developmentally regulated expression of hemoglobin subunits in avascular tissues" @default.
• W2078382040 cites W107591712 @default.
• W2078382040 cites W1578517328 @default.
• W2078382040 cites W1746447020 @default.
• W2078382040 cites W1886141633 @default.
• W2078382040 cites W1925667723 @default.
• W2078382040 cites W1950932745 @default.
• W2078382040 cites W1963923636 @default.
• W2078382040 cites W1967799899 @default.
• W2078382040 cites W1969814695 @default.
• W2078382040 cites W1974381392 @default.
• W2078382040 cites W1982603620 @default.
• W2078382040 cites W1982710170 @default.
• W2078382040 cites W1984164703 @default.
• W2078382040 cites W1991664409 @default.
• W2078382040 cites W1992924696 @default.
• W2078382040 cites W1995840664 @default.
• W2078382040 cites W1998729868 @default.
• W2078382040 cites W2000602253 @default.
• W2078382040 cites W2003406245 @default.
• W2078382040 cites W2006044129 @default.
• W2078382040 cites W2006542398 @default.
• W2078382040 cites W2008835405 @default.
• W2078382040 cites W2011995063 @default.
• W2078382040 cites W2014703113 @default.
• W2078382040 cites W2024347929 @default.
• W2078382040 cites W2028482584 @default.
• W2078382040 cites W2039024936 @default.
• W2078382040 cites W2042189418 @default.
• W2078382040 cites W2043209324 @default.
• W2078382040 cites W2043671022 @default.
• W2078382040 cites W2045899482 @default.
• W2078382040 cites W2048270230 @default.
• W2078382040 cites W2056843474 @default.
• W2078382040 cites W2062132538 @default.
• W2078382040 cites W2065387006 @default.
• W2078382040 cites W2065519682 @default.
• W2078382040 cites W2069449601 @default.
• W2078382040 cites W2071321087 @default.
• W2078382040 cites W2071421762 @default.
• W2078382040 cites W2074947501 @default.
• W2078382040 cites W2080719699 @default.
• W2078382040 cites W2080725398 @default.
• W2078382040 cites W2084625763 @default.
• W2078382040 cites W2096773218 @default.
• W2078382040 cites W2103478108 @default.
• W2078382040 cites W2105361655 @default.
• W2078382040 cites W2112654646 @default.
• W2078382040 cites W2122150311 @default.
• W2078382040 cites W2150274419 @default.
• W2078382040 cites W2156417130 @default.
• W2078382040 cites W2156706454 @default.
• W2078382040 cites W2159203488 @default.
• W2078382040 cites W2164549555 @default.
• W2078382040 cites W2168488235 @default.
• W2078382040 cites W2219678282 @default.
• W2078382040 cites W2308456886 @default.
• W2078382040 cites W2312776752 @default.
• W2078382040 cites W2405014033 @default.
• W2078382040 cites W2406014927 @default.
• W2078382040 cites W2410127224 @default.
• W2078382040 cites W2467769409 @default.
• W2078382040 cites W3025699485 @default.
• W2078382040 cites W616788132 @default.
• W2078382040 doi "https://doi.org/10.1387/ijdb.082597fm" @default.
• W2078382040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18956317" @default.
• W2078382040 hasPublicationYear "2008" @default.
• W2078382040 type Work @default.
• W2078382040 sameAs 2078382040 @default.
• W2078382040 citedByCount "21" @default.
• W2078382040 countsByYear W20783820402012 @default.
• W2078382040 countsByYear W20783820402013 @default.
• W2078382040 countsByYear W20783820402014 @default.
• W2078382040 countsByYear W20783820402015 @default.
• W2078382040 countsByYear W20783820402016 @default.
• W2078382040 countsByYear W20783820402018 @default.
• W2078382040 countsByYear W20783820402019 @default.
• W2078382040 countsByYear W20783820402020 @default.
• W2078382040 countsByYear W20783820402021 @default.
• W2078382040 countsByYear W20783820402023 @default.
• W2078382040 crossrefType "journal-article" @default.
• W2078382040 hasAuthorship W2078382040A5005293866 @default.
• W2078382040 hasAuthorship W2078382040A5005686833 @default.
• W2078382040 hasAuthorship W2078382040A5015814792 @default.
• W2078382040 hasAuthorship W2078382040A5024851123 @default.
• W2078382040 hasAuthorship W2078382040A5040517975 @default.
• W2078382040 hasAuthorship W2078382040A5041975628 @default.

• next