Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078382197> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2078382197 endingPage "358" @default.
- W2078382197 startingPage "352" @default.
- W2078382197 abstract "In the last decade the increase in therapeutic strategies aimed at mitochondrial targets has resulted in the need for novel delivery systems for the selective delivery of drugs and DNA into mitochondria. In this study, we have continued our efforts towards the development of the first mitochondriotropic drug and DNA delivery system (DQAsomes). Prepared from derivatives of the self-assembling mitochondriotropic bola-amphiphile dequalinium chloride, these vesicles bind and transport DNA to mitochondria in living mammalian cells where upon they have been shown to release the DNA on contact with mitochondrial membranes. We present data to demonstrate that oligonucleotides as well as plasmid DNA conjugated to a mitochondrial leader sequence (MLS) co-localize with mitochondria when delivered into mammalian cells by DQAsomes. In contrast to a commercially available DNA delivery vector, our vesicles appear to have a pronounced specificity for mitochondria. Further, the data strongly suggest that linear conjugates might be better suited to delivery into mitochondria and that in the absence of a mitochondria specific vector, the presence of a MLS-peptide conjugated to the DNA is alone not sufficient to direct the accumulation of DNA at mitochondria." @default.
- W2078382197 created "2016-06-24" @default.
- W2078382197 creator A5034000086 @default.
- W2078382197 creator A5056946556 @default.
- W2078382197 creator A5090380505 @default.
- W2078382197 date "2005-10-01" @default.
- W2078382197 modified "2023-09-26" @default.
- W2078382197 title "Mitochondrial leader sequence-plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria" @default.
- W2078382197 cites W1549152014 @default.
- W2078382197 cites W1963552167 @default.
- W2078382197 cites W1964317310 @default.
- W2078382197 cites W1965560696 @default.
- W2078382197 cites W1968016095 @default.
- W2078382197 cites W1969057288 @default.
- W2078382197 cites W1977539185 @default.
- W2078382197 cites W1991728780 @default.
- W2078382197 cites W2034203718 @default.
- W2078382197 cites W2051221827 @default.
- W2078382197 cites W2064633836 @default.
- W2078382197 cites W2067049036 @default.
- W2078382197 cites W2089922069 @default.
- W2078382197 cites W2116837113 @default.
- W2078382197 cites W2139808463 @default.
- W2078382197 cites W2186321860 @default.
- W2078382197 doi "https://doi.org/10.1016/j.mito.2005.07.001" @default.
- W2078382197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16154389" @default.
- W2078382197 hasPublicationYear "2005" @default.
- W2078382197 type Work @default.
- W2078382197 sameAs 2078382197 @default.
- W2078382197 citedByCount "95" @default.
- W2078382197 countsByYear W20783821972012 @default.
- W2078382197 countsByYear W20783821972013 @default.
- W2078382197 countsByYear W20783821972014 @default.
- W2078382197 countsByYear W20783821972015 @default.
- W2078382197 countsByYear W20783821972016 @default.
- W2078382197 countsByYear W20783821972017 @default.
- W2078382197 countsByYear W20783821972018 @default.
- W2078382197 countsByYear W20783821972019 @default.
- W2078382197 countsByYear W20783821972020 @default.
- W2078382197 countsByYear W20783821972021 @default.
- W2078382197 countsByYear W20783821972022 @default.
- W2078382197 countsByYear W20783821972023 @default.
- W2078382197 crossrefType "journal-article" @default.
- W2078382197 hasAuthorship W2078382197A5034000086 @default.
- W2078382197 hasAuthorship W2078382197A5056946556 @default.
- W2078382197 hasAuthorship W2078382197A5090380505 @default.
- W2078382197 hasConcept C104317684 @default.
- W2078382197 hasConcept C129312508 @default.
- W2078382197 hasConcept C130316041 @default.
- W2078382197 hasConcept C153911025 @default.
- W2078382197 hasConcept C22744801 @default.
- W2078382197 hasConcept C24586158 @default.
- W2078382197 hasConcept C28859421 @default.
- W2078382197 hasConcept C41625074 @default.
- W2078382197 hasConcept C552990157 @default.
- W2078382197 hasConcept C55493867 @default.
- W2078382197 hasConcept C86803240 @default.
- W2078382197 hasConcept C95444343 @default.
- W2078382197 hasConceptScore W2078382197C104317684 @default.
- W2078382197 hasConceptScore W2078382197C129312508 @default.
- W2078382197 hasConceptScore W2078382197C130316041 @default.
- W2078382197 hasConceptScore W2078382197C153911025 @default.
- W2078382197 hasConceptScore W2078382197C22744801 @default.
- W2078382197 hasConceptScore W2078382197C24586158 @default.
- W2078382197 hasConceptScore W2078382197C28859421 @default.
- W2078382197 hasConceptScore W2078382197C41625074 @default.
- W2078382197 hasConceptScore W2078382197C552990157 @default.
- W2078382197 hasConceptScore W2078382197C55493867 @default.
- W2078382197 hasConceptScore W2078382197C86803240 @default.
- W2078382197 hasConceptScore W2078382197C95444343 @default.
- W2078382197 hasIssue "5" @default.
- W2078382197 hasLocation W20783821971 @default.
- W2078382197 hasLocation W20783821972 @default.
- W2078382197 hasOpenAccess W2078382197 @default.
- W2078382197 hasPrimaryLocation W20783821971 @default.
- W2078382197 hasRelatedWork W2000752994 @default.
- W2078382197 hasRelatedWork W2035022637 @default.
- W2078382197 hasRelatedWork W2066137273 @default.
- W2078382197 hasRelatedWork W2067051684 @default.
- W2078382197 hasRelatedWork W2138716914 @default.
- W2078382197 hasRelatedWork W2472667586 @default.
- W2078382197 hasRelatedWork W4240130546 @default.
- W2078382197 hasRelatedWork W4247560166 @default.
- W2078382197 hasRelatedWork W4253474749 @default.
- W2078382197 hasRelatedWork W4255024550 @default.
- W2078382197 hasVolume "5" @default.
- W2078382197 isParatext "false" @default.
- W2078382197 isRetracted "false" @default.
- W2078382197 magId "2078382197" @default.
- W2078382197 workType "article" @default.