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• W2078383562 abstract "This study was designed to investigate the expression of the matrix degrading proteinase cathepsin B and its endogenous inhibitor cystatin C in rheumatoid arthritis (RA) with special regard to multinucleated synovial giant cells (SGC). We applied an immunohistochemical double-labeling technique. SGC strongly expressed cystatin C and CD68, but were negative for cathepsin B. This staining pattern occurred in osteoclasts as well. Our findings support the idea that in RA matrix destruction by cathepsin B is not mediated by SGC or osteoclasts, but by mononuclear synoviocytes." @default.
• W2078383562 created "2016-06-24" @default.
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• W2078383562 date "2000-08-01" @default.
• W2078383562 modified "2023-09-30" @default.
• W2078383562 title "Synovial giant cells in rheumatoid arthritis: Expression of cystatin C, but not of cathepsin B" @default.
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• W2078383562 doi "https://doi.org/10.1016/s0940-2993(00)80055-x" @default.
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