FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078384276> ?p ?o ?g. }

• W2078384276 endingPage "e1002879" @default.
• W2078384276 startingPage "e1002879" @default.
• W2078384276 abstract "We have recently observed that a fatty acid auxotrophic mutant (fatty acid synthase, Fas2Δ/Δ) of the emerging human pathogenic yeast Candida parapsilosis dies after incubation in various media including serum. In the present study we describe the mechanism for cell death induced by serum and glucose containing media. We show that Fas2Δ/Δ yeast cells are profoundly susceptible to glucose leading us to propose that yeast cells lacking fatty acids exhibit uncontrolled metabolism in response to glucose. We demonstrate that incubation of Fas2Δ/Δ yeast cells with serum leads to cell death, and this process can be prevented with inhibition of protein or DNA synthesis, indicating that newly synthesized cellular components are detrimental to the mutant cells. Furthermore, we have found that cell death is mediated by mitochondria. Suppression of electron transport enzymes using inhibitors such as cyanide or azide prevents ROS overproduction and Fas2Δ/Δ yeast cell death. Additionally, deletion of mitochondrial DNA, which encodes several subunits for enzymes of the electron transport chain, significantly reduces serum-induced Fas2Δ/Δ yeast cell death. Therefore, our results show that serum and glucose media induce Fas2Δ/Δ yeast cell death by triggering unbalanced metabolism, which is regulated by mitochondria. To our knowledge, this is the first study to critically define a link between cytosolic fatty acid synthesis and mitochondrial function in response to serum stress in C. parapsilosis." @default.
• W2078384276 created "2016-06-24" @default.
• W2078384276 creator A5001312410 @default.
• W2078384276 creator A5029938062 @default.
• W2078384276 creator A5032600704 @default.
• W2078384276 creator A5040798706 @default.
• W2078384276 creator A5070646365 @default.
• W2078384276 creator A5084339121 @default.
• W2078384276 date "2012-08-30" @default.
• W2078384276 modified "2023-10-07" @default.
• W2078384276 title "Inhibition of Candida parapsilosis Fatty Acid Synthase (Fas2) Induces Mitochondrial Cell Death in Serum" @default.
• W2078384276 cites W1523804360 @default.
• W2078384276 cites W1527059519 @default.
• W2078384276 cites W1571546288 @default.
• W2078384276 cites W1610336856 @default.
• W2078384276 cites W1792921716 @default.
• W2078384276 cites W1929090722 @default.
• W2078384276 cites W1968531757 @default.
• W2078384276 cites W1971925522 @default.
• W2078384276 cites W1987678916 @default.
• W2078384276 cites W1991846448 @default.
• W2078384276 cites W2003175642 @default.
• W2078384276 cites W2007283637 @default.
• W2078384276 cites W2009728680 @default.
• W2078384276 cites W2020972228 @default.
• W2078384276 cites W2030114688 @default.
• W2078384276 cites W2030628123 @default.
• W2078384276 cites W2033253988 @default.
• W2078384276 cites W2035847924 @default.
• W2078384276 cites W2036127346 @default.
• W2078384276 cites W2040318221 @default.
• W2078384276 cites W2051175351 @default.
• W2078384276 cites W2056868096 @default.
• W2078384276 cites W2085625452 @default.
• W2078384276 cites W2090416880 @default.
• W2078384276 cites W2099241550 @default.
• W2078384276 cites W2100145090 @default.
• W2078384276 cites W2107039058 @default.
• W2078384276 cites W2111262978 @default.
• W2078384276 cites W2114370486 @default.
• W2078384276 cites W2115132031 @default.
• W2078384276 cites W2115869334 @default.
• W2078384276 cites W2116355036 @default.
• W2078384276 cites W2120419643 @default.
• W2078384276 cites W2121702473 @default.
• W2078384276 cites W2122363207 @default.
• W2078384276 cites W2134687901 @default.
• W2078384276 cites W2135414511 @default.
• W2078384276 cites W2135715116 @default.
• W2078384276 cites W2136869823 @default.
• W2078384276 cites W2139552156 @default.
• W2078384276 cites W2149457744 @default.
• W2078384276 cites W2150492289 @default.
• W2078384276 cites W2153069806 @default.
• W2078384276 cites W2157380302 @default.
• W2078384276 cites W2159227723 @default.
• W2078384276 cites W2164498083 @default.
• W2078384276 doi "https://doi.org/10.1371/journal.ppat.1002879" @default.
• W2078384276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3431346" @default.
• W2078384276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22952445" @default.
• W2078384276 hasPublicationYear "2012" @default.
• W2078384276 type Work @default.
• W2078384276 sameAs 2078384276 @default.
• W2078384276 citedByCount "8" @default.
• W2078384276 countsByYear W20783842762014 @default.
• W2078384276 countsByYear W20783842762015 @default.
• W2078384276 countsByYear W20783842762016 @default.
• W2078384276 countsByYear W20783842762018 @default.
• W2078384276 countsByYear W20783842762020 @default.
• W2078384276 countsByYear W20783842762021 @default.
• W2078384276 crossrefType "journal-article" @default.
• W2078384276 hasAuthorship W2078384276A5001312410 @default.
• W2078384276 hasAuthorship W2078384276A5029938062 @default.
• W2078384276 hasAuthorship W2078384276A5032600704 @default.
• W2078384276 hasAuthorship W2078384276A5040798706 @default.
• W2078384276 hasAuthorship W2078384276A5070646365 @default.
• W2078384276 hasAuthorship W2078384276A5084339121 @default.
• W2078384276 hasBestOaLocation W20783842761 @default.
• W2078384276 hasConcept C190283241 @default.
• W2078384276 hasConcept C2779222958 @default.
• W2078384276 hasConcept C2779443200 @default.
• W2078384276 hasConcept C2780917455 @default.
• W2078384276 hasConcept C28859421 @default.
• W2078384276 hasConcept C31573885 @default.
• W2078384276 hasConcept C48289651 @default.
• W2078384276 hasConcept C543025807 @default.
• W2078384276 hasConcept C55493867 @default.
• W2078384276 hasConcept C86803240 @default.
• W2078384276 hasConcept C89423630 @default.
• W2078384276 hasConceptScore W2078384276C190283241 @default.
• W2078384276 hasConceptScore W2078384276C2779222958 @default.
• W2078384276 hasConceptScore W2078384276C2779443200 @default.
• W2078384276 hasConceptScore W2078384276C2780917455 @default.
• W2078384276 hasConceptScore W2078384276C28859421 @default.
• W2078384276 hasConceptScore W2078384276C31573885 @default.
• W2078384276 hasConceptScore W2078384276C48289651 @default.
• W2078384276 hasConceptScore W2078384276C543025807 @default.
• W2078384276 hasConceptScore W2078384276C55493867 @default.

• next