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- W2078385825 abstract "FEBRUARY 2015 AB78 Abstracts S A T U R D A Y 250 Salivary Microrna As a Biomarker for Monitoring Response to Treatment in Eosinophilic Esophagitis Theodore E. Kelbel, MD, Gisoo Ghaffari, MD, Maria Sena, Faoud T. Ishmael, MD, PhD, FAAAAI; Penn State Hershey Medical Center, Hershey, PA, SUNY Jamestown, NY, Penn State University College of Medicine, Hershey, PA. RATIONALE: Eosinophilic esophagitis (EoE) is a clinicopathological condition where endoscopic biopsies of the esophagus are required for diagnosis and monitoring the response to treatment. No non-invasive method of monitoring currently exists. MicroRNA (miRNA), regulate expression of many cytokines important in allergic disease and have been found in saliva. We hypothesize that salivary miRNAs are differentially expressed in EoE and can be used as biomarkers to monitor the response to treatment. METHODS: After IRB approval, fifteen adult patients with EoE (symptoms consistent with EoE, endoscopic biopsy with >_15 eosinophils per high powered field, and previous proton pump inhibitor therapy) were randomly enrolled to provide a saliva sample before and after 2 months of swallowed fluticasone therapy. Differences of miRNA expression were compared to healthy controls (n517) using Wilcoxin rank sum testing. Expression changes before and after treatment were analyzed by paired Ttest. A significance cutoff of 2-fold upregulation of miR-570-3p, -3613-5p, -4668-5p, and -30a-5p in EoE (p<0.01). After treatment, expression of miR-658 increased while expression of miR-3613-5p and -4668-5p decreased (p5 0.0027, 0.0314, and 0.0488 respectively). These results suggest miRNA expression differences can be seen at time of diagnosis and can change with treatment of EoE. CONCLUSIONS: Salivary miRNA represents a promising new tool for non-invasive, biomarkermonitoring of EoE. These differentially expressed miRNAs may have pathogenic roles in EoE." @default.
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- W2078385825 date "2015-02-01" @default.
- W2078385825 modified "2023-09-23" @default.
- W2078385825 title "Transcriptome Analysis of PPI-Responsive Esophageal Eosinophilia Reveals the Presence of an Eosinophilic Esophagitis Transcriptome Reversible By PPI Mono-Therapy and the Identification of PPI-Response Predictor Genes" @default.
- W2078385825 doi "https://doi.org/10.1016/j.jaci.2014.12.1188" @default.
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