Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078385930> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2078385930 endingPage "d5274" @default.
- W2078385930 startingPage "d5274" @default.
- W2078385930 abstract "Despite progress toward understanding the correlates of protective T cell immunity in HIV infection, the optimal approach to Ag delivery by vaccination remains uncertain. We characterized two immunodominant CD8 T cell populations generated in response to immunization of BALB/c mice with a replication-deficient adenovirus serotype 5 vector expressing the HIV-derived Gag and Pol proteins at equivalent levels. The Gag-AI9/H-2K<sup>d</sup> epitope elicited high-avidity CD8 T cell populations with architecturally diverse clonotypic repertoires that displayed potent lytic activity in vivo. In contrast, the Pol-LI9/H-2D<sup>d</sup> epitope elicited motif-constrained CD8 T cell repertoires that displayed lower levels of physical avidity and lytic activity despite equivalent measures of overall clonality. Although low-dose vaccination enhanced the functional profiles of both epitope-specific CD8 T cell populations, greater polyfunctionality was apparent within the Pol-LI9/H-2D<sup>d</sup> specificity. Higher proportions of central memory-like cells were present after low-dose vaccination and at later time points. However, there were no noteworthy phenotypic differences between epitope-specific CD8 T cell populations across vaccine doses or time points. Collectively, these data indicate that the functional and phenotypic properties of vaccine-induced CD8 T cell populations are sensitive to dose manipulation, yet constrained by epitope specificity in a clonotype-dependent manner." @default.
- W2078385930 created "2016-06-24" @default.
- W2078385930 creator A5051240379 @default.
- W2078385930 date "2011-09-06" @default.
- W2078385930 modified "2023-09-26" @default.
- W2078385930 title "Adenoidectomy in children with recurrent upper respiratory infections" @default.
- W2078385930 cites W1574784973 @default.
- W2078385930 cites W1969319896 @default.
- W2078385930 cites W1994032842 @default.
- W2078385930 cites W1995322617 @default.
- W2078385930 cites W2042844392 @default.
- W2078385930 cites W2050857666 @default.
- W2078385930 cites W2057278009 @default.
- W2078385930 cites W2085928375 @default.
- W2078385930 cites W2089114810 @default.
- W2078385930 cites W2125632702 @default.
- W2078385930 cites W2149579741 @default.
- W2078385930 cites W2314650992 @default.
- W2078385930 doi "https://doi.org/10.1136/bmj.d5274" @default.
- W2078385930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21896612" @default.
- W2078385930 hasPublicationYear "2011" @default.
- W2078385930 type Work @default.
- W2078385930 sameAs 2078385930 @default.
- W2078385930 citedByCount "2" @default.
- W2078385930 countsByYear W20783859302022 @default.
- W2078385930 crossrefType "journal-article" @default.
- W2078385930 hasAuthorship W2078385930A5051240379 @default.
- W2078385930 hasConcept C147483822 @default.
- W2078385930 hasConcept C154317977 @default.
- W2078385930 hasConcept C159047783 @default.
- W2078385930 hasConcept C167672396 @default.
- W2078385930 hasConcept C179223381 @default.
- W2078385930 hasConcept C182615771 @default.
- W2078385930 hasConcept C195616568 @default.
- W2078385930 hasConcept C202751555 @default.
- W2078385930 hasConcept C203014093 @default.
- W2078385930 hasConcept C22070199 @default.
- W2078385930 hasConcept C2522874641 @default.
- W2078385930 hasConcept C2776090121 @default.
- W2078385930 hasConcept C54355233 @default.
- W2078385930 hasConcept C86803240 @default.
- W2078385930 hasConcept C8891405 @default.
- W2078385930 hasConceptScore W2078385930C147483822 @default.
- W2078385930 hasConceptScore W2078385930C154317977 @default.
- W2078385930 hasConceptScore W2078385930C159047783 @default.
- W2078385930 hasConceptScore W2078385930C167672396 @default.
- W2078385930 hasConceptScore W2078385930C179223381 @default.
- W2078385930 hasConceptScore W2078385930C182615771 @default.
- W2078385930 hasConceptScore W2078385930C195616568 @default.
- W2078385930 hasConceptScore W2078385930C202751555 @default.
- W2078385930 hasConceptScore W2078385930C203014093 @default.
- W2078385930 hasConceptScore W2078385930C22070199 @default.
- W2078385930 hasConceptScore W2078385930C2522874641 @default.
- W2078385930 hasConceptScore W2078385930C2776090121 @default.
- W2078385930 hasConceptScore W2078385930C54355233 @default.
- W2078385930 hasConceptScore W2078385930C86803240 @default.
- W2078385930 hasConceptScore W2078385930C8891405 @default.
- W2078385930 hasIssue "sep06 1" @default.
- W2078385930 hasLocation W20783859301 @default.
- W2078385930 hasLocation W20783859302 @default.
- W2078385930 hasOpenAccess W2078385930 @default.
- W2078385930 hasPrimaryLocation W20783859301 @default.
- W2078385930 hasRelatedWork W1517459791 @default.
- W2078385930 hasRelatedWork W1558545452 @default.
- W2078385930 hasRelatedWork W2012280098 @default.
- W2078385930 hasRelatedWork W2033962007 @default.
- W2078385930 hasRelatedWork W2052483994 @default.
- W2078385930 hasRelatedWork W2140631420 @default.
- W2078385930 hasRelatedWork W2142769285 @default.
- W2078385930 hasRelatedWork W2801946978 @default.
- W2078385930 hasRelatedWork W3159349374 @default.
- W2078385930 hasRelatedWork W4254282151 @default.
- W2078385930 hasVolume "343" @default.
- W2078385930 isParatext "false" @default.
- W2078385930 isRetracted "false" @default.
- W2078385930 magId "2078385930" @default.
- W2078385930 workType "article" @default.