FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078388595> ?p ?o ?g. }

• W2078388595 endingPage "849" @default.
• W2078388595 startingPage "842" @default.
• W2078388595 abstract "Six 1,2,4-oxadiazole derivatives were prepared in order to compare their abilities to protect DNA against radical-mediated oxidation and to scavenge radicals. These derivatives had a structure based on disubstituted 1,2,4-oxadiazole, in which a vanillin group (A ring) and a substituted benzene group (B ring) were the substituents. The functional group at B ring was assigned as ortho- or meta-hydroxylbenzene group, ortho-chlorobenzene group, no group contained, and pyridine group or vanillin group at B ring. It was found that the compound with two vanillin groups attaching to oxadiazole can trap 2.05 radicals in protecting DNA against 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH)-induced oxidation, and the compound with an ortho-hydroxylbenzene group at B ring can trap 1.78 radicals. The compound with an ortho-chlorobenzene group at B ring exhibited the highest ability to inhibit ·OH-induced oxidation of DNA, while the compound with a meta-hydroxylbenzene group at B ring inhibited Cu2+/glutathione (GSH)-induced oxidation of DNA efficiently. The ortho- and para-hydroxylbenzene groups at B ring made the compounds possess the highest rate constant (k) in scavenging 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) cationic radical (ABTS+.) and 2,2′-diphenyl-1-picrylhydrazyl radical (DPPH). Therefore, only a few hydroxyl groups can markedly enhance the activity of the core-branched antioxidant, which may be a novel structural feature in designing antioxidant." @default.
• W2078388595 created "2016-06-24" @default.
• W2078388595 creator A5003038962 @default.
• W2078388595 creator A5063997421 @default.
• W2078388595 date "2013-04-01" @default.
• W2078388595 modified "2023-09-23" @default.
• W2078388595 title "Diaryl-1,2,4-oxadiazole antioxidants: Synthesis and properties of inhibiting the oxidation of DNA and scavenging radicals" @default.
• W2078388595 cites W1953644283 @default.
• W2078388595 cites W1966821517 @default.
• W2078388595 cites W1970043118 @default.
• W2078388595 cites W1970661834 @default.
• W2078388595 cites W1972680985 @default.
• W2078388595 cites W1986442322 @default.
• W2078388595 cites W1993462964 @default.
• W2078388595 cites W2004532199 @default.
• W2078388595 cites W2009156408 @default.
• W2078388595 cites W2012991711 @default.
• W2078388595 cites W2017412443 @default.
• W2078388595 cites W2024824638 @default.
• W2078388595 cites W2025973101 @default.
• W2078388595 cites W2027894947 @default.
• W2078388595 cites W2033954487 @default.
• W2078388595 cites W2037586146 @default.
• W2078388595 cites W2041902142 @default.
• W2078388595 cites W2054128947 @default.
• W2078388595 cites W2060783559 @default.
• W2078388595 cites W2065391946 @default.
• W2078388595 cites W2076058447 @default.
• W2078388595 cites W2076468372 @default.
• W2078388595 cites W2080422303 @default.
• W2078388595 cites W2081412929 @default.
• W2078388595 cites W2084468949 @default.
• W2078388595 cites W2097855182 @default.
• W2078388595 cites W2126522147 @default.
• W2078388595 cites W2133976543 @default.
• W2078388595 cites W2160799179 @default.
• W2078388595 cites W2164675156 @default.
• W2078388595 cites W2316584562 @default.
• W2078388595 cites W2330405466 @default.
• W2078388595 cites W2949756693 @default.
• W2078388595 doi "https://doi.org/10.1016/j.biochi.2012.12.005" @default.
• W2078388595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23246737" @default.
• W2078388595 hasPublicationYear "2013" @default.
• W2078388595 type Work @default.
• W2078388595 sameAs 2078388595 @default.
• W2078388595 citedByCount "12" @default.
• W2078388595 countsByYear W20783885952013 @default.
• W2078388595 countsByYear W20783885952014 @default.
• W2078388595 countsByYear W20783885952015 @default.
• W2078388595 countsByYear W20783885952019 @default.
• W2078388595 countsByYear W20783885952021 @default.
• W2078388595 crossrefType "journal-article" @default.
• W2078388595 hasAuthorship W2078388595A5003038962 @default.
• W2078388595 hasAuthorship W2078388595A5063997421 @default.
• W2078388595 hasConcept C139066938 @default.
• W2078388595 hasConcept C155647269 @default.
• W2078388595 hasConcept C161790260 @default.
• W2078388595 hasConcept C178790620 @default.
• W2078388595 hasConcept C185592680 @default.
• W2078388595 hasConcept C2776041390 @default.
• W2078388595 hasConcept C2777340834 @default.
• W2078388595 hasConcept C2778004101 @default.
• W2078388595 hasConcept C2779448499 @default.
• W2078388595 hasConcept C2780378348 @default.
• W2078388595 hasConcept C2781031786 @default.
• W2078388595 hasConcept C2781401929 @default.
• W2078388595 hasConcept C71240020 @default.
• W2078388595 hasConceptScore W2078388595C139066938 @default.
• W2078388595 hasConceptScore W2078388595C155647269 @default.
• W2078388595 hasConceptScore W2078388595C161790260 @default.
• W2078388595 hasConceptScore W2078388595C178790620 @default.
• W2078388595 hasConceptScore W2078388595C185592680 @default.
• W2078388595 hasConceptScore W2078388595C2776041390 @default.
• W2078388595 hasConceptScore W2078388595C2777340834 @default.
• W2078388595 hasConceptScore W2078388595C2778004101 @default.
• W2078388595 hasConceptScore W2078388595C2779448499 @default.
• W2078388595 hasConceptScore W2078388595C2780378348 @default.
• W2078388595 hasConceptScore W2078388595C2781031786 @default.
• W2078388595 hasConceptScore W2078388595C2781401929 @default.
• W2078388595 hasConceptScore W2078388595C71240020 @default.
• W2078388595 hasIssue "4" @default.
• W2078388595 hasLocation W20783885951 @default.
• W2078388595 hasLocation W20783885952 @default.
• W2078388595 hasOpenAccess W2078388595 @default.
• W2078388595 hasPrimaryLocation W20783885951 @default.
• W2078388595 hasRelatedWork W1978786984 @default.
• W2078388595 hasRelatedWork W2255961730 @default.
• W2078388595 hasRelatedWork W2380369464 @default.
• W2078388595 hasRelatedWork W2381986359 @default.
• W2078388595 hasRelatedWork W2393144551 @default.
• W2078388595 hasRelatedWork W2582886698 @default.
• W2078388595 hasRelatedWork W2717040626 @default.
• W2078388595 hasRelatedWork W2781240001 @default.
• W2078388595 hasRelatedWork W3011356796 @default.
• W2078388595 hasRelatedWork W2187793424 @default.
• W2078388595 hasVolume "95" @default.
• W2078388595 isParatext "false" @default.
• W2078388595 isRetracted "false" @default.

• next