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• W2078391119 abstract "When d(T-A) is irradiated at 254 nm in aqueous solution an internal photoadduct is formed between its constituent adenine and thymine bases. The resultant photoproduct, designated TA * , arises from a singlet excited state precursor; a similar photoreaction is not observed with d(C-A) or d(T-G). In contradistinction, irradiation of d(T-A) in frozen aqueous solution yields a dimeric photoproduct in which two d(T-A) molecules are coupled together by a (6-4) photoadduct linkage between their respective thymine bases. Both photoproducts have been extensively characterised by a combination of electron impact and fast atom bombardment mass spectrometry, UV, CD, 1 H NMR and fluorescence spectroscopy. Acid treatment of TA * gives 6-methylimidazo[4,5-b]pyridin-5-one whose identity was established by an independent chemical synthesis involving photorearrangoment of 6-methylimidazo N(4)-oxide. A tentative mechanism is presented to account for the acid degradation of TA * . The structure of the dimeric ice photoproduct follows from its cleavage, by snake venom phosphodiesterase, to 5'-dAMP and the (6-4) bimolecular photoadduct of thymidine; on acid hydrolysis it gives adenine and 6-(5'-methyl-2'-oxopyrlmidin-4'-yl)thymine." @default.
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• W2078391119 date "1984-01-01" @default.
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• W2078391119 title "The photochemistry of d(T-A) in aqueous solution and in ice" @default.
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• W2078391119 doi "https://doi.org/10.1093/nar/12.20.7929" @default.
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