FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078391207> ?p ?o ?g. }

• W2078391207 endingPage "158" @default.
• W2078391207 startingPage "149" @default.
• W2078391207 abstract "ABSTRACT A review is presented of the changes that occur in the pharmacodynamics of benzodiazepines during normal ageing and as a result of disease. Controlled studies in which subjects of different ages have received single doses of diazepam, temazepam, nitrazepam and flunitrazepam have consistently shown an increase in the response to benzodiazepines in the elderly which is not explained by the effects of disease or by altered plasma concentrations. In general, healthy elderly subjects have a 2–3 fold greater response compared with the young. This change appears to be due to a change in the post-receptor mechanism of action. Cerebral diazepam concentrations are similar in young and elderly rats, though older animals also show an increased response and no consistent changes have been demonstrated in brain receptor binding. However, benzodiazepine-induced increases in GABA binding and GABA-induced increases in post-synaptic inhibition have been reported to be greater in aged animals. Regular daily dosing with most benzodiazepines leads to drug accumulation which is proportional to the elimination half-life. Regular dosing with diazepam, chlordiazepoxide, nitrazepam and flurazepam has also been found to produce more sedation in the elderly, particularly long stay patients who have a high incidence of dementia, and those with a low albumen or chronic renal failure. A controlled trial of 1 week's dosing with 5 mg of nitrazepam or 20 mg of temazepam in elderly in-patients showed that these doses produced significant impairment of psychomotor performance the morning after the last dose. Only about 50% of the patients were affected and many of these were frail patients with mild dementia on rehabilitation or long stay wards. The doses prescribed for these types of patients should not exceed 2.5 mg of nitrazepam or 10 mg temazepam." @default.
• W2078391207 created "2016-06-24" @default.
• W2078391207 creator A5078484018 @default.
• W2078391207 date "1986-12-01" @default.
• W2078391207 modified "2023-09-27" @default.
• W2078391207 title "Benzodiazepine hypnotics in the elderly" @default.
• W2078391207 cites W182717727 @default.
• W2078391207 cites W1893214027 @default.
• W2078391207 cites W1965672832 @default.
• W2078391207 cites W1965870941 @default.
• W2078391207 cites W1971386092 @default.
• W2078391207 cites W1977512076 @default.
• W2078391207 cites W1990021877 @default.
• W2078391207 cites W1994063645 @default.
• W2078391207 cites W2010669389 @default.
• W2078391207 cites W2012670983 @default.
• W2078391207 cites W2021641960 @default.
• W2078391207 cites W2022600005 @default.
• W2078391207 cites W2023565062 @default.
• W2078391207 cites W2024185962 @default.
• W2078391207 cites W2028103355 @default.
• W2078391207 cites W2030435356 @default.
• W2078391207 cites W2042232934 @default.
• W2078391207 cites W2048695402 @default.
• W2078391207 cites W2055164994 @default.
• W2078391207 cites W2056777296 @default.
• W2078391207 cites W2060419377 @default.
• W2078391207 cites W2062567284 @default.
• W2078391207 cites W2065405906 @default.
• W2078391207 cites W2075238796 @default.
• W2078391207 cites W2088058112 @default.
• W2078391207 cites W2121746032 @default.
• W2078391207 cites W2125294805 @default.
• W2078391207 cites W2128270899 @default.
• W2078391207 cites W2142260355 @default.
• W2078391207 cites W2423092877 @default.
• W2078391207 cites W2580149512 @default.
• W2078391207 cites W3024199366 @default.
• W2078391207 cites W4366064309 @default.
• W2078391207 cites W4367275972 @default.
• W2078391207 doi "https://doi.org/10.1111/j.1600-0447.1986.tb08992.x" @default.
• W2078391207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2883822" @default.
• W2078391207 hasPublicationYear "1986" @default.
• W2078391207 type Work @default.
• W2078391207 sameAs 2078391207 @default.
• W2078391207 citedByCount "40" @default.
• W2078391207 countsByYear W20783912072013 @default.
• W2078391207 countsByYear W20783912072014 @default.
• W2078391207 countsByYear W20783912072016 @default.
• W2078391207 countsByYear W20783912072022 @default.
• W2078391207 crossrefType "journal-article" @default.
• W2078391207 hasAuthorship W2078391207A5078484018 @default.
• W2078391207 hasConcept C111113717 @default.
• W2078391207 hasConcept C112705442 @default.
• W2078391207 hasConcept C118552586 @default.
• W2078391207 hasConcept C126322002 @default.
• W2078391207 hasConcept C170493617 @default.
• W2078391207 hasConcept C2776156762 @default.
• W2078391207 hasConcept C2776175493 @default.
• W2078391207 hasConcept C2776814716 @default.
• W2078391207 hasConcept C2777196872 @default.
• W2078391207 hasConcept C2777207853 @default.
• W2078391207 hasConcept C2777288759 @default.
• W2078391207 hasConcept C2778173252 @default.
• W2078391207 hasConcept C2778325228 @default.
• W2078391207 hasConcept C2779706987 @default.
• W2078391207 hasConcept C2779738154 @default.
• W2078391207 hasConcept C2780930544 @default.
• W2078391207 hasConcept C2781006864 @default.
• W2078391207 hasConcept C42219234 @default.
• W2078391207 hasConcept C558461103 @default.
• W2078391207 hasConcept C71924100 @default.
• W2078391207 hasConcept C98274493 @default.
• W2078391207 hasConceptScore W2078391207C111113717 @default.
• W2078391207 hasConceptScore W2078391207C112705442 @default.
• W2078391207 hasConceptScore W2078391207C118552586 @default.
• W2078391207 hasConceptScore W2078391207C126322002 @default.
• W2078391207 hasConceptScore W2078391207C170493617 @default.
• W2078391207 hasConceptScore W2078391207C2776156762 @default.
• W2078391207 hasConceptScore W2078391207C2776175493 @default.
• W2078391207 hasConceptScore W2078391207C2776814716 @default.
• W2078391207 hasConceptScore W2078391207C2777196872 @default.
• W2078391207 hasConceptScore W2078391207C2777207853 @default.
• W2078391207 hasConceptScore W2078391207C2777288759 @default.
• W2078391207 hasConceptScore W2078391207C2778173252 @default.
• W2078391207 hasConceptScore W2078391207C2778325228 @default.
• W2078391207 hasConceptScore W2078391207C2779706987 @default.
• W2078391207 hasConceptScore W2078391207C2779738154 @default.
• W2078391207 hasConceptScore W2078391207C2780930544 @default.
• W2078391207 hasConceptScore W2078391207C2781006864 @default.
• W2078391207 hasConceptScore W2078391207C42219234 @default.
• W2078391207 hasConceptScore W2078391207C558461103 @default.
• W2078391207 hasConceptScore W2078391207C71924100 @default.
• W2078391207 hasConceptScore W2078391207C98274493 @default.
• W2078391207 hasIssue "S332" @default.
• W2078391207 hasLocation W20783912071 @default.
• W2078391207 hasLocation W20783912072 @default.
• W2078391207 hasOpenAccess W2078391207 @default.

• next