FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078392596> ?p ?o ?g. }

• W2078392596 endingPage "715" @default.
• W2078392596 startingPage "711" @default.
• W2078392596 abstract "It has been postulated that, in addition to the crucial role of androgens, estrogens may be involved in development of prostate hyperplasia and cancer. In rats, combined administration of estrogen and androgen synergistically increases ventral prostate weight, and continued treatment results in the development of glandular hyperplasia. Prostate adenocarcinoma can be induced by chemical carcinogens in rats, and estrogen given together with an androgen generally shortens the latent period or increases the incidence and/or multiplicity of carcinomas. However, the mechanisms responsible for these synergistic effects of estrogen and androgen are poorly understood. In the present study, we examined the combined effects of 17beta-estradiol (E2) and testosterone (T) on gene expression in an early stage of prostate hyperplasia in an F344 rat model. ERalpha expression, which has been suggested to contribute to development of prostatic hyperplasia, was increased by the combined treatment with T and E2, while it was suppressed by T alone. Expression levels of two androgen-responsive genes, probasin and kallikrein S3, were increased in the ventral prostate of rats treated with T plus E2 for 4 weeks in a dose-dependent manner, while short-term treatment did not alter the expression. These results suggested that enhancing effects of E2 on transcription of androgen-responsive genes, as well as an increased level of ERalpha may play roles in the synergistic effects of E2 on T-induced prostate hyperplasia." @default.
• W2078392596 created "2016-06-24" @default.
• W2078392596 creator A5018083376 @default.
• W2078392596 creator A5044663343 @default.
• W2078392596 creator A5046075354 @default.
• W2078392596 creator A5091300315 @default.
• W2078392596 date "2004-09-01" @default.
• W2078392596 modified "2023-10-14" @default.
• W2078392596 title "Estrogen enhancement of androgen-responsive gene expression in hormone-induced hyperplasia in the ventral prostate of F344 rats" @default.
• W2078392596 cites W14779780 @default.
• W2078392596 cites W1564991728 @default.
• W2078392596 cites W1967133956 @default.
• W2078392596 cites W1968614586 @default.
• W2078392596 cites W1972219906 @default.
• W2078392596 cites W1974257634 @default.
• W2078392596 cites W1993923853 @default.
• W2078392596 cites W1999216570 @default.
• W2078392596 cites W2009481857 @default.
• W2078392596 cites W2018991261 @default.
• W2078392596 cites W2019818723 @default.
• W2078392596 cites W2024900047 @default.
• W2078392596 cites W2055478303 @default.
• W2078392596 cites W2058177423 @default.
• W2078392596 cites W2061805003 @default.
• W2078392596 cites W2064040393 @default.
• W2078392596 cites W2073353512 @default.
• W2078392596 cites W2075204803 @default.
• W2078392596 cites W2081979496 @default.
• W2078392596 cites W2084457622 @default.
• W2078392596 cites W2122680090 @default.
• W2078392596 cites W2125698713 @default.
• W2078392596 cites W2157104106 @default.
• W2078392596 cites W2161623422 @default.
• W2078392596 cites W2162671228 @default.
• W2078392596 cites W2169618540 @default.
• W2078392596 cites W2411999976 @default.
• W2078392596 cites W4235415101 @default.
• W2078392596 cites W4237902576 @default.
• W2078392596 cites W4240018663 @default.
• W2078392596 cites W4243370970 @default.
• W2078392596 cites W4250634643 @default.
• W2078392596 doi "https://doi.org/10.1111/j.1349-7006.2004.tb03250.x" @default.
• W2078392596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15471555" @default.
• W2078392596 hasPublicationYear "2004" @default.
• W2078392596 type Work @default.
• W2078392596 sameAs 2078392596 @default.
• W2078392596 citedByCount "13" @default.
• W2078392596 countsByYear W20783925962012 @default.
• W2078392596 countsByYear W20783925962017 @default.
• W2078392596 crossrefType "journal-article" @default.
• W2078392596 hasAuthorship W2078392596A5018083376 @default.
• W2078392596 hasAuthorship W2078392596A5044663343 @default.
• W2078392596 hasAuthorship W2078392596A5046075354 @default.
• W2078392596 hasAuthorship W2078392596A5091300315 @default.
• W2078392596 hasBestOaLocation W20783925961 @default.
• W2078392596 hasConcept C121608353 @default.
• W2078392596 hasConcept C126322002 @default.
• W2078392596 hasConcept C134018914 @default.
• W2078392596 hasConcept C2776235491 @default.
• W2078392596 hasConcept C2777164284 @default.
• W2078392596 hasConcept C2777562237 @default.
• W2078392596 hasConcept C2777911890 @default.
• W2078392596 hasConcept C2779279991 @default.
• W2078392596 hasConcept C2780192828 @default.
• W2078392596 hasConcept C502942594 @default.
• W2078392596 hasConcept C71315377 @default.
• W2078392596 hasConcept C71924100 @default.
• W2078392596 hasConcept C86803240 @default.
• W2078392596 hasConceptScore W2078392596C121608353 @default.
• W2078392596 hasConceptScore W2078392596C126322002 @default.
• W2078392596 hasConceptScore W2078392596C134018914 @default.
• W2078392596 hasConceptScore W2078392596C2776235491 @default.
• W2078392596 hasConceptScore W2078392596C2777164284 @default.
• W2078392596 hasConceptScore W2078392596C2777562237 @default.
• W2078392596 hasConceptScore W2078392596C2777911890 @default.
• W2078392596 hasConceptScore W2078392596C2779279991 @default.
• W2078392596 hasConceptScore W2078392596C2780192828 @default.
• W2078392596 hasConceptScore W2078392596C502942594 @default.
• W2078392596 hasConceptScore W2078392596C71315377 @default.
• W2078392596 hasConceptScore W2078392596C71924100 @default.
• W2078392596 hasConceptScore W2078392596C86803240 @default.
• W2078392596 hasIssue "9" @default.
• W2078392596 hasLocation W20783925961 @default.
• W2078392596 hasLocation W20783925962 @default.
• W2078392596 hasOpenAccess W2078392596 @default.
• W2078392596 hasPrimaryLocation W20783925961 @default.
• W2078392596 hasRelatedWork W1968690445 @default.
• W2078392596 hasRelatedWork W1981433740 @default.
• W2078392596 hasRelatedWork W1986311037 @default.
• W2078392596 hasRelatedWork W1986969712 @default.
• W2078392596 hasRelatedWork W2023030003 @default.
• W2078392596 hasRelatedWork W2027210979 @default.
• W2078392596 hasRelatedWork W2032603988 @default.
• W2078392596 hasRelatedWork W2040706140 @default.
• W2078392596 hasRelatedWork W2060300693 @default.
• W2078392596 hasRelatedWork W2061554880 @default.
• W2078392596 hasVolume "95" @default.
• W2078392596 isParatext "false" @default.

• next