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- W2078392605 abstract "Abstract Background and Objectives The macrophage is an important early cellular marker related to risk of future rupture of atherosclerotic plaques. Two‐channel two‐photon luminescence (TPL) microscopy combined with optical coherence tomography (OCT) was used to detect, and further characterize the distribution of aorta‐based macrophages using plasmonic gold nanorose as an imaging contrast agent. Study Design/Materials and Methods Nanorose uptake by macrophages was identified by TPL microscopy in macrophage cell culture. Ex vivo aorta segments (8 × 8 × 2 mm 3 ) rich in macrophages from a rabbit model of aorta inflammation were imaged by TPL microscopy in combination with OCT. Aorta histological sections (5 µm in thickness) were also imaged by TPL microscopy. Results Merged two‐channel TPL images showed the lateral and depth distribution of nanorose‐loaded macrophages (confirmed by RAM‐11 stain) and other aorta components (e.g., elastin fiber and lipid droplet), suggesting that nanorose‐loaded macrophages are diffusively distributed and mostly detected superficially within 20 µm from the luminal surface of the aorta. Moreover, OCT images depicted detailed surface structure of the diseased aorta. Conclusions Results suggest that TPL microscopy combined with OCT can simultaneously reveal macrophage distribution with respect to aorta surface structure, which has the potential to detect vulnerable plaques and monitor plaque‐based macrophages overtime during cardiovascular interventions. Lasers Surg. Med. 44:49–59, 2012. © 2012 Wiley Periodicals, Inc." @default.
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- W2078392605 date "2012-01-01" @default.
- W2078392605 modified "2023-10-12" @default.
- W2078392605 title "Combined two-photon luminescence microscopy and OCT for macrophage detection in the hypercholesterolemic rabbit aorta using plasmonic gold nanorose" @default.
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- W2078392605 cites W1752451218 @default.
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- W2078392605 cites W1973893754 @default.
- W2078392605 cites W1977756163 @default.
- W2078392605 cites W1980930513 @default.
- W2078392605 cites W1984055074 @default.
- W2078392605 cites W1984107213 @default.
- W2078392605 cites W1984232298 @default.
- W2078392605 cites W1985997959 @default.
- W2078392605 cites W1986805734 @default.
- W2078392605 cites W1989988580 @default.
- W2078392605 cites W1995641184 @default.
- W2078392605 cites W1997366819 @default.
- W2078392605 cites W2005454916 @default.
- W2078392605 cites W2008111093 @default.
- W2078392605 cites W2009412597 @default.
- W2078392605 cites W2011809692 @default.
- W2078392605 cites W2016524967 @default.
- W2078392605 cites W2025782661 @default.
- W2078392605 cites W2034072319 @default.
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- W2078392605 cites W2037617087 @default.
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- W2078392605 cites W2053634523 @default.
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- W2078392605 cites W2060635700 @default.
- W2078392605 cites W2065182922 @default.
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- W2078392605 doi "https://doi.org/10.1002/lsm.21153" @default.
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