FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078393006> ?p ?o ?g. }

• W2078393006 endingPage "5595" @default.
• W2078393006 startingPage "5590" @default.
• W2078393006 abstract "The structural changes accompanying stretch-induced early unfolding events were investigated for the four type III fibronectin (FN-III) modules, FN-III(7), FN-III(8), FN-III(9), and FN-III(10) by using steered molecular dynamics. Simulations revealed that two main energy barriers, I and II, have to be overcome to initiate unraveling of FN-III's tertiary structure. In crossing the first barrier, the two opposing beta-sheets of FN-III are rotated against each other such that the beta-strands of both beta-sheets align parallel to the force vector (aligned state). All further events in the unfolding pathway proceed from this intermediate state. A second energy barrier has to be overcome to break the first major cluster of hydrogen bonds between adjacent beta-strands. Simulations revealed that the height of barrier I varied significantly among the four modules studied, being largest for FN-III(7) and lowest for FN-III(10), whereas the height of barrier II showed little variation. Key residues affecting the mechanical stability of FN-III modules were identified. These results suggest that FN-III modules can be prestretched into an intermediate state with only minor changes to their tertiary structures. FN-III(10), for example, extends 12 A from the native twisted to the intermediate aligned state, and an additional 10 A from the aligned state to further unfolding where the first beta-strand is peeled away. The implications of the existence of intermediate states regarding the elasticity of fibrillar fibers and the stretch-induced exposure of cryptic sites are discussed." @default.
• W2078393006 created "2016-06-24" @default.
• W2078393006 creator A5006145832 @default.
• W2078393006 creator A5029996336 @default.
• W2078393006 creator A5040449994 @default.
• W2078393006 creator A5091606719 @default.
• W2078393006 date "2001-05-01" @default.
• W2078393006 modified "2023-10-11" @default.
• W2078393006 title "Comparison of the early stages of forced unfolding for fibronectin type III modules" @default.
• W2078393006 cites W1519478518 @default.
• W2078393006 cites W1572609533 @default.
• W2078393006 cites W1579363245 @default.
• W2078393006 cites W1976499671 @default.
• W2078393006 cites W1981252803 @default.
• W2078393006 cites W1984348923 @default.
• W2078393006 cites W1988715261 @default.
• W2078393006 cites W2003473363 @default.
• W2078393006 cites W2019877102 @default.
• W2078393006 cites W2020388963 @default.
• W2078393006 cites W2024410294 @default.
• W2078393006 cites W2024528177 @default.
• W2078393006 cites W2024895368 @default.
• W2078393006 cites W2027408247 @default.
• W2078393006 cites W2028811978 @default.
• W2078393006 cites W2029667189 @default.
• W2078393006 cites W2032986905 @default.
• W2078393006 cites W2036691875 @default.
• W2078393006 cites W2037720334 @default.
• W2078393006 cites W2045032642 @default.
• W2078393006 cites W2049280483 @default.
• W2078393006 cites W2052776438 @default.
• W2078393006 cites W2062713862 @default.
• W2078393006 cites W2079255790 @default.
• W2078393006 cites W2082488805 @default.
• W2078393006 cites W2092597250 @default.
• W2078393006 cites W2100202577 @default.
• W2078393006 cites W2100833559 @default.
• W2078393006 cites W2105614327 @default.
• W2078393006 cites W2106010460 @default.
• W2078393006 cites W2122308713 @default.
• W2078393006 cites W2135888012 @default.
• W2078393006 cites W2147791888 @default.
• W2078393006 cites W2151913921 @default.
• W2078393006 cites W2156912277 @default.
• W2078393006 cites W2172039086 @default.
• W2078393006 cites W4240593622 @default.
• W2078393006 cites W45922315 @default.
• W2078393006 doi "https://doi.org/10.1073/pnas.101582198" @default.
• W2078393006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/33257" @default.
• W2078393006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11331785" @default.
• W2078393006 hasPublicationYear "2001" @default.
• W2078393006 type Work @default.
• W2078393006 sameAs 2078393006 @default.
• W2078393006 citedByCount "122" @default.
• W2078393006 countsByYear W20783930062012 @default.
• W2078393006 countsByYear W20783930062013 @default.
• W2078393006 countsByYear W20783930062014 @default.
• W2078393006 countsByYear W20783930062015 @default.
• W2078393006 countsByYear W20783930062016 @default.
• W2078393006 countsByYear W20783930062017 @default.
• W2078393006 countsByYear W20783930062018 @default.
• W2078393006 countsByYear W20783930062019 @default.
• W2078393006 countsByYear W20783930062020 @default.
• W2078393006 countsByYear W20783930062021 @default.
• W2078393006 countsByYear W20783930062022 @default.
• W2078393006 countsByYear W20783930062023 @default.
• W2078393006 crossrefType "journal-article" @default.
• W2078393006 hasAuthorship W2078393006A5006145832 @default.
• W2078393006 hasAuthorship W2078393006A5029996336 @default.
• W2078393006 hasAuthorship W2078393006A5040449994 @default.
• W2078393006 hasAuthorship W2078393006A5091606719 @default.
• W2078393006 hasBestOaLocation W20783930061 @default.
• W2078393006 hasConcept C112887158 @default.
• W2078393006 hasConcept C121332964 @default.
• W2078393006 hasConcept C12554922 @default.
• W2078393006 hasConcept C147597530 @default.
• W2078393006 hasConcept C164866538 @default.
• W2078393006 hasConcept C178790620 @default.
• W2078393006 hasConcept C184779094 @default.
• W2078393006 hasConcept C185592680 @default.
• W2078393006 hasConcept C189165786 @default.
• W2078393006 hasConcept C192562407 @default.
• W2078393006 hasConcept C199360897 @default.
• W2078393006 hasConcept C2776174256 @default.
• W2078393006 hasConcept C2780702060 @default.
• W2078393006 hasConcept C32909587 @default.
• W2078393006 hasConcept C41008148 @default.
• W2078393006 hasConcept C55493867 @default.
• W2078393006 hasConcept C59593255 @default.
• W2078393006 hasConcept C8010536 @default.
• W2078393006 hasConcept C86492073 @default.
• W2078393006 hasConcept C86803240 @default.
• W2078393006 hasConceptScore W2078393006C112887158 @default.
• W2078393006 hasConceptScore W2078393006C121332964 @default.
• W2078393006 hasConceptScore W2078393006C12554922 @default.
• W2078393006 hasConceptScore W2078393006C147597530 @default.
• W2078393006 hasConceptScore W2078393006C164866538 @default.
• W2078393006 hasConceptScore W2078393006C178790620 @default.

• next