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• W2078393982 endingPage "1617" @default.
• W2078393982 startingPage "1611" @default.
• W2078393982 abstract "MAMMALIAN olfactory epithelium produces new neurons rapidly throughout adulthood. Here, we demonstrate that precursor cells harvested from the adult olfactory epithelium, when transplanted into the nasal mucosa of host rats exposed previously to an olfactotoxic gas, engraft and participate in neuroepithelial reconstitution. In contrast to their normal neuronal fate in situ, grafted precursors harvested from bulbectomized donors produced non-neuronal cells as well as neurons. These results demonstrate that epithelial precursors activated following olfactory bulbectomy are not irreversibly committed to making neurons. Thus, olfactory progenitors are subject to a form of feedback control in vivo that regulates the types of cells that they produce within a broader-than-neuronal repertoire." @default.
• W2078393982 created "2016-06-24" @default.
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• W2078393982 date "1998-05-01" @default.
• W2078393982 modified "2023-09-28" @default.
• W2078393982 title "Transplantation of multipotent progenitors from the adult olfactory epithelium" @default.
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• W2078393982 doi "https://doi.org/10.1097/00001756-199805110-00065" @default.
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