Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078394930> ?p ?o ?g. }
- W2078394930 endingPage "1314" @default.
- W2078394930 startingPage "1303" @default.
- W2078394930 abstract "Apoptosis is a conserved homeostatic process critical for organ and tissue morphogenesis, development, and senescence. This form of programmed cell death also participates in the etiology of several human diseases including cancer, neurodegenerative, and autoimmune disorders. Although the signaling pathways leading to the progression of apoptosis have been extensively characterized, recent studies highlight the regulatory role of changes in the intracellular milieu (permissive apoptotic environment) in the efficient activation of the cell death machinery. In particular, glutathione (GSH) depletion is a common feature of apoptotic cell death triggered by a wide variety of stimuli including activation of death receptors, stress, environmental agents, and cytotoxic drugs. Although initial studies suggested that GSH depletion was only a byproduct of oxidative stress generated during cell death, recent discoveries suggest that GSH depletion and post-translational modifications of proteins through glutathionylation are critical regulators of apoptosis. Here, we reformulate these emerging paradigms into our current understanding of cell death mechanisms." @default.
- W2078394930 created "2016-06-24" @default.
- W2078394930 creator A5001320954 @default.
- W2078394930 creator A5009015359 @default.
- W2078394930 date "2009-08-07" @default.
- W2078394930 modified "2023-10-11" @default.
- W2078394930 title "Apoptosis and glutathione: beyond an antioxidant" @default.
- W2078394930 cites W1481921126 @default.
- W2078394930 cites W1543428671 @default.
- W2078394930 cites W1544068855 @default.
- W2078394930 cites W1558564171 @default.
- W2078394930 cites W1595640022 @default.
- W2078394930 cites W1601880487 @default.
- W2078394930 cites W1612119967 @default.
- W2078394930 cites W170881775 @default.
- W2078394930 cites W1942154378 @default.
- W2078394930 cites W1963545685 @default.
- W2078394930 cites W1969291345 @default.
- W2078394930 cites W1970240791 @default.
- W2078394930 cites W1971336125 @default.
- W2078394930 cites W1972301357 @default.
- W2078394930 cites W1973308033 @default.
- W2078394930 cites W1976375430 @default.
- W2078394930 cites W1976733864 @default.
- W2078394930 cites W1976881265 @default.
- W2078394930 cites W1977225705 @default.
- W2078394930 cites W1977596178 @default.
- W2078394930 cites W1979655239 @default.
- W2078394930 cites W1980385765 @default.
- W2078394930 cites W1980505675 @default.
- W2078394930 cites W1982460960 @default.
- W2078394930 cites W1982584241 @default.
- W2078394930 cites W1983968962 @default.
- W2078394930 cites W1985904396 @default.
- W2078394930 cites W1987355375 @default.
- W2078394930 cites W1987552859 @default.
- W2078394930 cites W1990185228 @default.
- W2078394930 cites W1990456739 @default.
- W2078394930 cites W1991220156 @default.
- W2078394930 cites W1992823317 @default.
- W2078394930 cites W1993763219 @default.
- W2078394930 cites W1993766071 @default.
- W2078394930 cites W1994220134 @default.
- W2078394930 cites W1995024323 @default.
- W2078394930 cites W1996826558 @default.
- W2078394930 cites W1997171049 @default.
- W2078394930 cites W1999070086 @default.
- W2078394930 cites W1999879498 @default.
- W2078394930 cites W2002112397 @default.
- W2078394930 cites W2002402006 @default.
- W2078394930 cites W2003890477 @default.
- W2078394930 cites W2006610864 @default.
- W2078394930 cites W2007794772 @default.
- W2078394930 cites W2009304280 @default.
- W2078394930 cites W2009479459 @default.
- W2078394930 cites W2011768800 @default.
- W2078394930 cites W2013705864 @default.
- W2078394930 cites W2014008140 @default.
- W2078394930 cites W2016068398 @default.
- W2078394930 cites W2017950381 @default.
- W2078394930 cites W2018542769 @default.
- W2078394930 cites W2022380364 @default.
- W2078394930 cites W2022841709 @default.
- W2078394930 cites W2023951767 @default.
- W2078394930 cites W2025038110 @default.
- W2078394930 cites W2026353189 @default.
- W2078394930 cites W2026875029 @default.
- W2078394930 cites W2032368822 @default.
- W2078394930 cites W2034618739 @default.
- W2078394930 cites W2040739900 @default.
- W2078394930 cites W2041770695 @default.
- W2078394930 cites W2042254126 @default.
- W2078394930 cites W2043541543 @default.
- W2078394930 cites W2043738387 @default.
- W2078394930 cites W2046112470 @default.
- W2078394930 cites W2047630113 @default.
- W2078394930 cites W2048700223 @default.
- W2078394930 cites W2051614284 @default.
- W2078394930 cites W2053067834 @default.
- W2078394930 cites W2054129051 @default.
- W2078394930 cites W2056333208 @default.
- W2078394930 cites W2061402035 @default.
- W2078394930 cites W2062145582 @default.
- W2078394930 cites W2065773243 @default.
- W2078394930 cites W2067351147 @default.
- W2078394930 cites W2068521882 @default.
- W2078394930 cites W2068807148 @default.
- W2078394930 cites W2069924169 @default.
- W2078394930 cites W2070874778 @default.
- W2078394930 cites W2071392805 @default.
- W2078394930 cites W2074225260 @default.
- W2078394930 cites W2074359673 @default.
- W2078394930 cites W2074839068 @default.
- W2078394930 cites W2075412225 @default.
- W2078394930 cites W2078094121 @default.
- W2078394930 cites W2079495263 @default.
- W2078394930 cites W2079705176 @default.
- W2078394930 cites W2079891959 @default.