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- W2078395532 abstract "Significance Over 90% of cancer cells express telomerase, which is required for their survival. However, telomerase inhibitors alone have so far failed to provide any significant clinical benefit. Therefore, identifying and targeting genes that can enhance the effects of telomerase inhibitors will greatly benefit a large population of cancer patients. We find that simultaneous inhibition of p21 and telomerase synergistically suppresses tumor growth. We also show that our approach is useful for treating p53 mutant cancers, when used with therapies that restore the function of mutant p53. We anticipate that simultaneous targeting of p21 and telomerase will overcome the current limitation of single-agent telomerase therapeutics and provide an effective method to treat cancers that rely on telomerase activity for survival." @default.
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- W2078395532 date "2014-07-14" @default.
- W2078395532 modified "2023-10-11" @default.
- W2078395532 title "Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A" @default.
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- W2078395532 doi "https://doi.org/10.1073/pnas.1411370111" @default.
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