Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078395819> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2078395819 abstract "We examined the effects of prolonged exposure of cardiac cells in primary culture to the partial beta-adrenoceptor agonist prenalterol and inhibitors of phosphodiesterase on their subsequent ability to increase intracellular cyclic AMP during a 5-min exposure to 50 microM isoprenaline (receptor responsiveness). Although prenalterol possesses only 7% of the agonist activity of isoprenaline on adenylate cyclase, it induces extensive beta-adrenoceptor desensitization. Three hours after exposing the cells to 1 microM prenalterol, beta-adrenoceptor responsiveness was reduced by 40% (p less than 0.05), whereas after 12 h the reduction averaged 55%. Prolonging the incubation time to 48 h had no further effect on the magnitude of receptor desensitization. The magnitude of the desensitization was concentration dependent. On exposure of cells to 10(-8) M prenalterol for 16 h, receptor responsiveness was reduced by 19%, and at concentrations of 1 microM and higher responsiveness was reduced by 60% (p less than 0.01). Receptor desensitization appeared to be due to an inability of receptors to activate adenylate cyclase as well as to receptor loss. To investigate if beta-adrenoceptor desensitization as well as receptor loss could be mediated by cyclic AMP, the cells were exposed for 16 h to inhibitors of phosphodiesterase. Exposure of cells to the phosphodiesterase inhibitor isobutylmethylxanthine (0.1 mM) (which increased intracellular cyclic AMP by between 50 and 150%) also induced receptor desensitization. The reduction in receptor responsiveness averaged 62% (p less than 0.01). The loss in responsiveness could be accounted for by an inability of receptors to activate adenylate cyclase as well as by receptor loss.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2078395819 created "2016-06-24" @default.
- W2078395819 creator A5067667648 @default.
- W2078395819 creator A5075494494 @default.
- W2078395819 date "1984-09-01" @default.
- W2078395819 modified "2023-10-18" @default.
- W2078395819 title "Role of Cyclic AMP in Cardiac β-Adrenoceptor Desensitization" @default.
- W2078395819 doi "https://doi.org/10.1097/00005344-198409000-00009" @default.
- W2078395819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6209482" @default.
- W2078395819 hasPublicationYear "1984" @default.
- W2078395819 type Work @default.
- W2078395819 sameAs 2078395819 @default.
- W2078395819 citedByCount "11" @default.
- W2078395819 crossrefType "journal-article" @default.
- W2078395819 hasAuthorship W2078395819A5067667648 @default.
- W2078395819 hasAuthorship W2078395819A5075494494 @default.
- W2078395819 hasBestOaLocation W20783958191 @default.
- W2078395819 hasConcept C126322002 @default.
- W2078395819 hasConcept C134018914 @default.
- W2078395819 hasConcept C170493617 @default.
- W2078395819 hasConcept C180526460 @default.
- W2078395819 hasConcept C181199279 @default.
- W2078395819 hasConcept C185592680 @default.
- W2078395819 hasConcept C24998067 @default.
- W2078395819 hasConcept C2776090920 @default.
- W2078395819 hasConcept C2776766087 @default.
- W2078395819 hasConcept C2778938600 @default.
- W2078395819 hasConcept C2779779143 @default.
- W2078395819 hasConcept C2780069284 @default.
- W2078395819 hasConcept C55493867 @default.
- W2078395819 hasConcept C62826618 @default.
- W2078395819 hasConcept C71924100 @default.
- W2078395819 hasConcept C79879829 @default.
- W2078395819 hasConcept C86803240 @default.
- W2078395819 hasConcept C92759361 @default.
- W2078395819 hasConceptScore W2078395819C126322002 @default.
- W2078395819 hasConceptScore W2078395819C134018914 @default.
- W2078395819 hasConceptScore W2078395819C170493617 @default.
- W2078395819 hasConceptScore W2078395819C180526460 @default.
- W2078395819 hasConceptScore W2078395819C181199279 @default.
- W2078395819 hasConceptScore W2078395819C185592680 @default.
- W2078395819 hasConceptScore W2078395819C24998067 @default.
- W2078395819 hasConceptScore W2078395819C2776090920 @default.
- W2078395819 hasConceptScore W2078395819C2776766087 @default.
- W2078395819 hasConceptScore W2078395819C2778938600 @default.
- W2078395819 hasConceptScore W2078395819C2779779143 @default.
- W2078395819 hasConceptScore W2078395819C2780069284 @default.
- W2078395819 hasConceptScore W2078395819C55493867 @default.
- W2078395819 hasConceptScore W2078395819C62826618 @default.
- W2078395819 hasConceptScore W2078395819C71924100 @default.
- W2078395819 hasConceptScore W2078395819C79879829 @default.
- W2078395819 hasConceptScore W2078395819C86803240 @default.
- W2078395819 hasConceptScore W2078395819C92759361 @default.
- W2078395819 hasLocation W20783958191 @default.
- W2078395819 hasLocation W20783958192 @default.
- W2078395819 hasOpenAccess W2078395819 @default.
- W2078395819 hasPrimaryLocation W20783958191 @default.
- W2078395819 hasRelatedWork W1963728354 @default.
- W2078395819 hasRelatedWork W1967812487 @default.
- W2078395819 hasRelatedWork W2078395819 @default.
- W2078395819 hasRelatedWork W2103831035 @default.
- W2078395819 hasRelatedWork W2137123290 @default.
- W2078395819 hasRelatedWork W2155585839 @default.
- W2078395819 hasRelatedWork W2166602181 @default.
- W2078395819 hasRelatedWork W2197787172 @default.
- W2078395819 hasRelatedWork W2342389649 @default.
- W2078395819 hasRelatedWork W2404351303 @default.
- W2078395819 isParatext "false" @default.
- W2078395819 isRetracted "false" @default.
- W2078395819 magId "2078395819" @default.
- W2078395819 workType "article" @default.