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• W2078395870 abstract "The novel thermoresponsive polycations poly(N-vinylbutyramide-co-vinylamide) (poly(NVBA-co-VAm)), with different mole ratios of poly(VAm) (PVAm):poly(NVBA) (PNVBA), were synthesized as a biomaterial by free radical copolymerization of poly(N-vinylbutyramide-co-N-vinylformamide) (poly(NVBA-co-NVF), followed by acid hydrolysis. Such poly(N-vinylamide)s do not generate toxic low-molecular-weight amine compounds by hydrolysis, although the poly(acrylamide) structural isomers do. The mole ratio of PVAm and PNVBA was varied by adjusting the NVF:NVBA mol% feeding ratio used in the copolymerization. The lower critical solution temperature (LCST) of the obtained copolymers was investigated and compared with that of PNVBA. PNVBA showed an LCST of 32 °C, while that for poly(NVBA-co-VAm) increased as the VAm mole ratio increased (due to the increasing hydrophilicity), and the more physiologically relevant temperature (for humans) of 36.5 °C was obtained at a VAm mole ratio of 5%. Furthermore, the LCST of these copolymers not only depended on the VAm mole ratios but also on the pH, the concentration of the copolymer solution and ionic strength. Variation in the copolymer LCST could lead to several applications, especially for copolymers with an LCST value around physiological temperature that would potentially be of merit for a controlled drug or biomolecule delivery system. The novel thermoresponsive polycation, poly(N-vinylbutyramide-co-vinylamide) (poly(NVBA-co-VAm)), was synthesized by free radical copolymerization of poly(N-vinylbutyramide-co-N-vinylformamide) (poly(NVBA-co-NVF), followed by acid hydrolysis. The mole ratio of PVAm and PNVBA was varied by adjusting the feeding ratio of NVF and NVBA. PNVBA showed a lower critical solution temperature of 32 °C, while that for poly(NVBA-co-VAm) increased as the VAm mole ratio increased owing to the increasing hydrophilicity, and the more physiologically relevant temperature of 36.5 °C was obtained at a VAm mole ratio of 5%." @default.
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• W2078395870 date "2013-02-27" @default.
• W2078395870 modified "2023-10-18" @default.
• W2078395870 title "Synthesis of a thermosensitive polycation by random copolymerization of N-vinylformamide and N-vinylbutyramide" @default.
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• W2078395870 doi "https://doi.org/10.1038/pj.2013.12" @default.
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