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- W2078395913 abstract "Polybrominated aromatic natural products are pervasive in the marine food web. Genetic and biochemical data now establish their biosynthetic origins in marine bacteria, revealing a physiological brominase that uses an unusual decarboxylative mechanism. Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention because of their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynthesis are not known. Here we report marine bacteria as producers of PBDEs and establish a genetic and molecular foundation for their production that unifies paradigms for the elaboration of bromophenols and bromopyrroles abundant in marine biota. We provide biochemical evidence of marine brominases revealing decarboxylative-halogenation enzymology previously unknown among halogenating enzymes. Biosynthetic motifs discovered in our study were used to mine sequence databases to discover unrealized marine bacterial producers of organobromine compounds." @default.
- W2078395913 created "2016-06-24" @default.
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- W2078395913 date "2014-06-29" @default.
- W2078395913 modified "2023-10-01" @default.
- W2078395913 title "Biosynthesis of polybrominated aromatic organic compounds by marine bacteria" @default.
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- W2078395913 doi "https://doi.org/10.1038/nchembio.1564" @default.
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