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• W2078397102 abstract "Purpose: To evaluate the effect of glucocorticoids on the innate immunity of corneal epithelial cells.Methods: Human corneal epithelial cell lines (HCEC) were co-cultured with LPS and hydrocortisone to determine whether hydrocortisone modulates the expression and function of TLR2, 4. The release of IL-6, 8 from cultured HCEC was measured in the presence and absence of specific blocking antibodies to TLR2, 4. The proteins of TLR2, 4 were also compared by Western blot.Results: Incubation of HCEC with LPS upregulated the expression of TLR2, 4 and increased the release of IL-6, 8. This upregulation was enhanced by low-concentration hydrocortisone, but inhibited by high-concentration hydrocortisone. The concentration of IL-6, 8 was also enhanced by low-concentration hydrocortisone and inhibited by high-concentration hydrocortisone.Conclusions: Low-concentration hydrocortisone enhances the expression and function of TLRs in HCEC and provides evidence for a novel function of glucocorticoids in innate immunity." @default.
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• W2078397102 date "2011-07-19" @default.
• W2078397102 modified "2023-09-24" @default.
• W2078397102 title "Differential Effects of Low- and High-dose Glucocorticoids on the Innate Immunity of Corneal Epithelium in Vitro" @default.
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• W2078397102 doi "https://doi.org/10.3109/09273948.2011.569110" @default.
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