Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078397624> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2078397624 endingPage "131" @default.
- W2078397624 startingPage "125" @default.
- W2078397624 abstract "Clinical studies indicate that patients with acute schizophrenia may benefit from benzodiazepine treatment. Therefore we investigated the benzodiazepine receptor distribution and diazepam binding in 20 patients with DSM-III schizophrenia using single photon emission computed tomography (SPECT) with iomazenil as the ligand. In each patient, two SPECT images were obtained: SPECT 1 was obtained 2 h after intravenous injection of 200 MBq I-123-iomazenil. Following SPECT 1, patients received 10 mg diazepam intravenously. Twenty min later, SPECT 2 was started. The highest iomazenil uptake was found in the occipital cortex followed by the frontal and temporal cortices. Baseline iomazenil uptake in the medial frontal cortex was significantly (P < 0.05) correlated with the BPRS total score (r = 0.46). Diazepam injection led to a significant activity decrease in iomazenil binding which was greatest in the frontal regions of interest. With respect to the medial frontal cortex, this effect was significantly (P < 0.05) more pronounced in patients with a remitting than a chronic course of the disorder. These findings suggest that changes of the benzodiazepine receptor system in the frontal cortex may be associated with severity and chronicity of schizophrenia." @default.
- W2078397624 created "2016-06-24" @default.
- W2078397624 creator A5006591792 @default.
- W2078397624 creator A5024091596 @default.
- W2078397624 creator A5080937883 @default.
- W2078397624 creator A5081088898 @default.
- W2078397624 date "1997-02-01" @default.
- W2078397624 modified "2023-09-23" @default.
- W2078397624 title "Benzodiazepine receptor distribution and diazepam binding in schizophrenia: an exploratory study" @default.
- W2078397624 cites W1514573559 @default.
- W2078397624 cites W1967662860 @default.
- W2078397624 cites W1983597913 @default.
- W2078397624 cites W1986668301 @default.
- W2078397624 cites W2008621323 @default.
- W2078397624 cites W2011128970 @default.
- W2078397624 cites W2017938047 @default.
- W2078397624 cites W2027646804 @default.
- W2078397624 cites W2041726742 @default.
- W2078397624 cites W2044479424 @default.
- W2078397624 cites W2048961423 @default.
- W2078397624 cites W2068298897 @default.
- W2078397624 cites W2082902281 @default.
- W2078397624 cites W2087866447 @default.
- W2078397624 cites W2094264939 @default.
- W2078397624 cites W2127776863 @default.
- W2078397624 cites W2163854332 @default.
- W2078397624 cites W2165075766 @default.
- W2078397624 cites W4251508433 @default.
- W2078397624 doi "https://doi.org/10.1016/s0925-4927(96)02843-0" @default.
- W2078397624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9104759" @default.
- W2078397624 hasPublicationYear "1997" @default.
- W2078397624 type Work @default.
- W2078397624 sameAs 2078397624 @default.
- W2078397624 citedByCount "26" @default.
- W2078397624 countsByYear W20783976242012 @default.
- W2078397624 countsByYear W20783976242015 @default.
- W2078397624 countsByYear W20783976242017 @default.
- W2078397624 crossrefType "journal-article" @default.
- W2078397624 hasAuthorship W2078397624A5006591792 @default.
- W2078397624 hasAuthorship W2078397624A5024091596 @default.
- W2078397624 hasAuthorship W2078397624A5080937883 @default.
- W2078397624 hasAuthorship W2078397624A5081088898 @default.
- W2078397624 hasConcept C118552586 @default.
- W2078397624 hasConcept C126322002 @default.
- W2078397624 hasConcept C15744967 @default.
- W2078397624 hasConcept C169760540 @default.
- W2078397624 hasConcept C170493617 @default.
- W2078397624 hasConcept C2776175493 @default.
- W2078397624 hasConcept C2776412080 @default.
- W2078397624 hasConcept C2777348757 @default.
- W2078397624 hasConcept C2778173252 @default.
- W2078397624 hasConcept C2780441642 @default.
- W2078397624 hasConcept C2983163835 @default.
- W2078397624 hasConcept C2984398910 @default.
- W2078397624 hasConcept C2989005 @default.
- W2078397624 hasConcept C2993858690 @default.
- W2078397624 hasConcept C42219234 @default.
- W2078397624 hasConcept C71924100 @default.
- W2078397624 hasConceptScore W2078397624C118552586 @default.
- W2078397624 hasConceptScore W2078397624C126322002 @default.
- W2078397624 hasConceptScore W2078397624C15744967 @default.
- W2078397624 hasConceptScore W2078397624C169760540 @default.
- W2078397624 hasConceptScore W2078397624C170493617 @default.
- W2078397624 hasConceptScore W2078397624C2776175493 @default.
- W2078397624 hasConceptScore W2078397624C2776412080 @default.
- W2078397624 hasConceptScore W2078397624C2777348757 @default.
- W2078397624 hasConceptScore W2078397624C2778173252 @default.
- W2078397624 hasConceptScore W2078397624C2780441642 @default.
- W2078397624 hasConceptScore W2078397624C2983163835 @default.
- W2078397624 hasConceptScore W2078397624C2984398910 @default.
- W2078397624 hasConceptScore W2078397624C2989005 @default.
- W2078397624 hasConceptScore W2078397624C2993858690 @default.
- W2078397624 hasConceptScore W2078397624C42219234 @default.
- W2078397624 hasConceptScore W2078397624C71924100 @default.
- W2078397624 hasIssue "2-3" @default.
- W2078397624 hasLocation W20783976241 @default.
- W2078397624 hasLocation W20783976242 @default.
- W2078397624 hasOpenAccess W2078397624 @default.
- W2078397624 hasPrimaryLocation W20783976241 @default.
- W2078397624 hasRelatedWork W1985638084 @default.
- W2078397624 hasRelatedWork W2005967785 @default.
- W2078397624 hasRelatedWork W2023678351 @default.
- W2078397624 hasRelatedWork W2027607723 @default.
- W2078397624 hasRelatedWork W2029967769 @default.
- W2078397624 hasRelatedWork W2038101840 @default.
- W2078397624 hasRelatedWork W2049535425 @default.
- W2078397624 hasRelatedWork W2058721387 @default.
- W2078397624 hasRelatedWork W2078397624 @default.
- W2078397624 hasRelatedWork W2622212983 @default.
- W2078397624 hasVolume "68" @default.
- W2078397624 isParatext "false" @default.
- W2078397624 isRetracted "false" @default.
- W2078397624 magId "2078397624" @default.
- W2078397624 workType "article" @default.