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- W2078399190 abstract "ISEE-0632 Background and Objective: The increased proportional mortality due to Parkinson's disease (PD) observed for veterans suggests that factors associated with exposure to armed forces environments may play a role in the etiology of PD. This analysis was conducted to examine the relative importance of occupational exposure to armed forces environments, occupational herbicide exposure, smoking, family history of PD, and head trauma as risk factors for PD. Methods: The data were collected in 1989 in a population-based case-control study of PD in Calgary, Canada. Non-demented cases (75 men, 55 women) were selected from a case register of Calgary residents with neurologist-confirmed PD. For each case, two matched (sex and age + or – 2.5 years) community controls were selected by random digit dialing. Cases and controls were interviewed using a structured questionnaire. The data were analyzed using conditional logistic regression analysis. Results: Ninety-nine men (30 cases, 68 controls) and 11 women (7 cases, 4 controls) gave a history of exposure to armed forces environments. For men, with adjustment for occupational herbicide exposure, smoking, family history of PD, and head trauma, which were significant predictors of PD risk, the odd ratio was 0.77 (95% CI: 0.33–1.79) for occupational exposure to armed forces environments. For women, with adjustment for family history of PD, the only other significant predictor of PD risk, the odds ratio was 4.77 (95% CI: 1.09–20.87) for occupational exposure to armed forces environments. Conclusion: The results suggest the hypothesis of a positive association between occupational exposure to armed forces environments and Parkinson's disease risk. Larger studies are needed to test the hypothesis and determine if there is a gender difference." @default.
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- W2078399190 date "2009-11-01" @default.
- W2078399190 modified "2023-09-26" @default.
- W2078399190 title "Parkinsonʼs Disease, Gender, and Occupational Exposure to Armed Forces Environments" @default.
- W2078399190 doi "https://doi.org/10.1097/01.ede.0000362923.93690.28" @default.
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