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- W2078403750 abstract "Summary Rabbits were treated by injection with hypercholesteremic-rooster lipoprotein antigen to protect them from cholesterol-induced atherosclerosis in accordance with the published observations of Gero et al . During the 6-week lipoprotein-injection period 28 rabbits received weekly intramuscular injections of lipoproteins which supplied 22.5 mg protein per rabbit. Following the immunization period the rabbits were given cholesterol-supplemented feed for 16 weeks. Atherosclerosis was evaluated on the basis of grading of aortal lesions at three sites, development of arcus senilis, aorta cholesterol content, and serum-cholesterol level. On the basis of these criteria, the lipoprotein pre-treatment did not exert any protective effect in the 23 surviving rabbits. It was noted that these rabbits had serum-cholesterol levels approximately twice as high as those reported by Gero et al ., and that the serological responses were no higher than 10- 3 compared with responses at a dilution of 10- 4 obtained by the above authors; in the absence of absorption studies a high degree of serological specificity for lipoprotein cannot be assumed." @default.
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- W2078403750 date "1961-05-01" @default.
- W2078403750 modified "2023-09-26" @default.
- W2078403750 title "Atherosclerosis in rabbits following treatment with heterologous lipoprotein" @default.
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- W2078403750 doi "https://doi.org/10.1016/s0368-1319(61)80035-5" @default.
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