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- W2078407123 abstract "Diaminedithiols (DADT) are known to form neutral-lipophilic complexes with 99mTc in aqueous solutions, where they are readily formed in high yields and demonstrate excellent stability. A new triaminedithiol (TADT) ligand was synthesized, characterized and shown to form a neutral-lipophilic 99mTc-chelate. The biodistribution of this 99mTc chelate in rats showed that its uptake in brain or heart following i.v. injection of the 99mTc chelate was low, but activity taken up was retained over a long period of time. The in vivo and in vitro properties of this chelate indicate the possibility that chemical modification of this TADT ligand may produce ligand systems that form 99mTc chelates with suitable diagnostic properties." @default.
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- W2078407123 date "1992-10-01" @default.
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- W2078407123 title "Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate" @default.
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- W2078407123 doi "https://doi.org/10.1016/0883-2897(92)90141-k" @default.
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