Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078408086> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2078408086 endingPage "184" @default.
- W2078408086 startingPage "175" @default.
- W2078408086 abstract "We have compared the protective effect of fructose in normal Ringer solution during the onset and progression of cell injury induced by paracetamol in rat liver slices with the protective effect of glucose and fructose-1,6-diphosphate. Liver slices obtained from phenobarbitone-induced and non-induced rats were used in a model in vitro system. Slices were exposed to 10 mM paracetamol for 120 min and then incubated without paracetamol in the presence or absence of protective agents for a further 240 min. Cell injury was quantified by measuring leakage of lactate dehydrogenase (LDH) and potassium (K+). Adenosinetriphosphate (ATP) levels were measured using the luciferin-luciferase bioluminescence assay. Addition of higher concentrations of glucose (10-50 mM) to Ringer solution were not found to result in protection at the end of incubation in paracetamol-treated slices obtained from phenobarbitone-induced rats. Neither did sucrose nor mannitol protect. However, exclusion of glucose from Ringer solution resulted in cell injury in paracetamol-treated slices obtained from non-induced rats. Methionine, a known antidote for paracetamol poisoning, failed to protect in this instances but fructose did protect. This suggests that the presence of a glycolytic substrate plays a crucial role in cell protection. Further evidence for this is the finding that iodoacetate, an inhibitor of glycolysis, not only increase cell injury in paracetamol-treated slices but also reverses fructose protection. Fructose-1,6-diphosphate was found to protect against the onset and progression of cell injury in paracetamol-treated slices obtained from phenobarbitone induced rats. This protective agent is found to maintain high ATP levels and cell viability in paracetamol-treated slices at a time when paracetamol-treated slices show a profound loss of ATP levels and a significant increase in cell injury as measured by leakage of LDH and K+." @default.
- W2078408086 created "2016-06-24" @default.
- W2078408086 creator A5038240164 @default.
- W2078408086 creator A5060149935 @default.
- W2078408086 date "1996-04-01" @default.
- W2078408086 modified "2023-10-13" @default.
- W2078408086 title "Comparison of protection by fructose against paracetamol injury with protection by glucose and fructose-1,6-diphosphate" @default.
- W2078408086 cites W1514660221 @default.
- W2078408086 cites W164871310 @default.
- W2078408086 cites W1725680005 @default.
- W2078408086 cites W1775749144 @default.
- W2078408086 cites W1902442984 @default.
- W2078408086 cites W1953642784 @default.
- W2078408086 cites W1984555958 @default.
- W2078408086 cites W1985609185 @default.
- W2078408086 cites W1989657286 @default.
- W2078408086 cites W1991588046 @default.
- W2078408086 cites W1992953427 @default.
- W2078408086 cites W1999132889 @default.
- W2078408086 cites W2010546628 @default.
- W2078408086 cites W2012141631 @default.
- W2078408086 cites W2018780547 @default.
- W2078408086 cites W2027397755 @default.
- W2078408086 cites W2030115186 @default.
- W2078408086 cites W2048894296 @default.
- W2078408086 cites W2049453944 @default.
- W2078408086 cites W2074965404 @default.
- W2078408086 cites W2086130857 @default.
- W2078408086 cites W2089498355 @default.
- W2078408086 cites W2092774668 @default.
- W2078408086 cites W2134883783 @default.
- W2078408086 cites W2155174050 @default.
- W2078408086 cites W4323521851 @default.
- W2078408086 doi "https://doi.org/10.1016/0300-483x(95)03280-s" @default.
- W2078408086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8658536" @default.
- W2078408086 hasPublicationYear "1996" @default.
- W2078408086 type Work @default.
- W2078408086 sameAs 2078408086 @default.
- W2078408086 citedByCount "9" @default.
- W2078408086 countsByYear W20784080862015 @default.
- W2078408086 countsByYear W20784080862018 @default.
- W2078408086 crossrefType "journal-article" @default.
- W2078408086 hasAuthorship W2078408086A5038240164 @default.
- W2078408086 hasAuthorship W2078408086A5060149935 @default.
- W2078408086 hasConcept C178790620 @default.
- W2078408086 hasConcept C181199279 @default.
- W2078408086 hasConcept C185592680 @default.
- W2078408086 hasConcept C20251656 @default.
- W2078408086 hasConcept C2776970464 @default.
- W2078408086 hasConcept C2777318727 @default.
- W2078408086 hasConcept C2778445172 @default.
- W2078408086 hasConcept C2779365888 @default.
- W2078408086 hasConcept C29730261 @default.
- W2078408086 hasConcept C55493867 @default.
- W2078408086 hasConcept C71924100 @default.
- W2078408086 hasConcept C98274493 @default.
- W2078408086 hasConceptScore W2078408086C178790620 @default.
- W2078408086 hasConceptScore W2078408086C181199279 @default.
- W2078408086 hasConceptScore W2078408086C185592680 @default.
- W2078408086 hasConceptScore W2078408086C20251656 @default.
- W2078408086 hasConceptScore W2078408086C2776970464 @default.
- W2078408086 hasConceptScore W2078408086C2777318727 @default.
- W2078408086 hasConceptScore W2078408086C2778445172 @default.
- W2078408086 hasConceptScore W2078408086C2779365888 @default.
- W2078408086 hasConceptScore W2078408086C29730261 @default.
- W2078408086 hasConceptScore W2078408086C55493867 @default.
- W2078408086 hasConceptScore W2078408086C71924100 @default.
- W2078408086 hasConceptScore W2078408086C98274493 @default.
- W2078408086 hasIssue "3" @default.
- W2078408086 hasLocation W20784080861 @default.
- W2078408086 hasLocation W20784080862 @default.
- W2078408086 hasOpenAccess W2078408086 @default.
- W2078408086 hasPrimaryLocation W20784080861 @default.
- W2078408086 hasRelatedWork W1610606864 @default.
- W2078408086 hasRelatedWork W1921034080 @default.
- W2078408086 hasRelatedWork W1956951694 @default.
- W2078408086 hasRelatedWork W2008102720 @default.
- W2078408086 hasRelatedWork W2078408086 @default.
- W2078408086 hasRelatedWork W2083887714 @default.
- W2078408086 hasRelatedWork W2107457410 @default.
- W2078408086 hasRelatedWork W2199199070 @default.
- W2078408086 hasRelatedWork W2413608823 @default.
- W2078408086 hasRelatedWork W2806129804 @default.
- W2078408086 hasVolume "108" @default.
- W2078408086 isParatext "false" @default.
- W2078408086 isRetracted "false" @default.
- W2078408086 magId "2078408086" @default.
- W2078408086 workType "article" @default.