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• W2078409242 abstract "Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are key elements of multidrug regimens, called HAART (Highly Active Antiretroviral Therapy), that are used to treat HIV-1 infections. Elucidation of the structure–activity relationships of the thiocarbamate moiety of the previous published lead compound 2 provided a series of novel tetrahydroquinoline derivatives as potent inhibitors of HIV-1 RT with nanomolar intrinsic activity on the WT and key mutant enzymes and potent antiviral activity in infected cells. The SAR optimization, mutation profiles, preparation of compounds, and pharmacokinetic profile of compounds are described." @default.
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• W2078409242 date "2009-09-01" @default.
• W2078409242 modified "2023-10-03" @default.
• W2078409242 title "Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants" @default.
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• W2078409242 doi "https://doi.org/10.1016/j.bmcl.2009.07.031" @default.
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