Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078412111> ?p ?o ?g. }
- W2078412111 abstract "An interpretation of the metabolic response to injury in patients with severe accidental or surgical trauma is made. In the last century, various authors attributed a meaning to the post-traumatic inflammatory response by using teleological arguments. Their interpretations of this response, not only facilitates integrating the knowledge, but also the flow from the bench to the bedside, which is the main objective of modern translational research. The goal of the current review is to correlate the metabolic changes with the three phenotypes -ischemia-reperfusion, leukocytic and angiogenic- that the patients express during the evolution of the systemic inflammatory response. The sequence in the expression of multiple metabolic systems that becomes progressively more elaborate and complex in severe injured patients urges for more detailed knowledge in order to establish the most adequate metabolic support according to the evolutive phase. Thus, clinicians must employ different treatment strategies based on the different metabolic phases when caring for this challenging patient population. Perhaps, the best therapeutic option would be to favor early hypometabolism during the ischemia-reperfusion phase, to boost the antienzymatic metabolism and to reduce hypermetabolism during the leukocytic phase through the early administration of enteral nutrition and the modulation of the acute phase response. Lastly, the early epithelial regeneration of the injured organs and tissues by means of an oxidative metabolism would reduce the fibrotic sequelae in these severely injured patients." @default.
- W2078412111 created "2016-06-24" @default.
- W2078412111 creator A5011871761 @default.
- W2078412111 creator A5029499371 @default.
- W2078412111 creator A5034104118 @default.
- W2078412111 creator A5048651154 @default.
- W2078412111 date "2010-05-17" @default.
- W2078412111 modified "2023-10-17" @default.
- W2078412111 title "A Review of metabolic staging in severely injured patients" @default.
- W2078412111 cites W1496826797 @default.
- W2078412111 cites W168035116 @default.
- W2078412111 cites W1823324621 @default.
- W2078412111 cites W1966321927 @default.
- W2078412111 cites W1969034842 @default.
- W2078412111 cites W1969674478 @default.
- W2078412111 cites W1969868235 @default.
- W2078412111 cites W1970068821 @default.
- W2078412111 cites W1971323804 @default.
- W2078412111 cites W1971885504 @default.
- W2078412111 cites W1972163001 @default.
- W2078412111 cites W1980334357 @default.
- W2078412111 cites W1985235191 @default.
- W2078412111 cites W1991458707 @default.
- W2078412111 cites W1991680271 @default.
- W2078412111 cites W1992973826 @default.
- W2078412111 cites W1998416239 @default.
- W2078412111 cites W1998761071 @default.
- W2078412111 cites W1999085278 @default.
- W2078412111 cites W1999864846 @default.
- W2078412111 cites W2000284263 @default.
- W2078412111 cites W2002764610 @default.
- W2078412111 cites W2007888565 @default.
- W2078412111 cites W2014058353 @default.
- W2078412111 cites W2015808765 @default.
- W2078412111 cites W2017310486 @default.
- W2078412111 cites W2017542989 @default.
- W2078412111 cites W2027080565 @default.
- W2078412111 cites W2030974887 @default.
- W2078412111 cites W2033119740 @default.
- W2078412111 cites W2034773990 @default.
- W2078412111 cites W2041260419 @default.
- W2078412111 cites W2046594601 @default.
- W2078412111 cites W2052564398 @default.
- W2078412111 cites W2055691049 @default.
- W2078412111 cites W2060762124 @default.
- W2078412111 cites W2064104050 @default.
- W2078412111 cites W2067240672 @default.
- W2078412111 cites W2068201049 @default.
- W2078412111 cites W2072889522 @default.
- W2078412111 cites W2073299912 @default.
- W2078412111 cites W2073446553 @default.
- W2078412111 cites W2074509163 @default.
- W2078412111 cites W2076115307 @default.
- W2078412111 cites W2076122670 @default.
- W2078412111 cites W2077086033 @default.
- W2078412111 cites W2079011939 @default.
- W2078412111 cites W2079340094 @default.
- W2078412111 cites W2079498607 @default.
- W2078412111 cites W2081095555 @default.
- W2078412111 cites W2081841784 @default.
- W2078412111 cites W2083132140 @default.
- W2078412111 cites W2084904685 @default.
- W2078412111 cites W2085054959 @default.
- W2078412111 cites W2091142254 @default.
- W2078412111 cites W2091326259 @default.
- W2078412111 cites W2091522759 @default.
- W2078412111 cites W2094572398 @default.
- W2078412111 cites W2095897782 @default.
- W2078412111 cites W2096556922 @default.
- W2078412111 cites W2103121273 @default.
- W2078412111 cites W2104551938 @default.
- W2078412111 cites W2106030214 @default.
- W2078412111 cites W2107370823 @default.
- W2078412111 cites W2107443816 @default.
- W2078412111 cites W2108473982 @default.
- W2078412111 cites W2112558371 @default.
- W2078412111 cites W2113311703 @default.
- W2078412111 cites W2116886160 @default.
- W2078412111 cites W2120699390 @default.
- W2078412111 cites W2134528746 @default.
- W2078412111 cites W2135977257 @default.
- W2078412111 cites W2142863049 @default.
- W2078412111 cites W2144175766 @default.
- W2078412111 cites W2145398823 @default.
- W2078412111 cites W2146282578 @default.
- W2078412111 cites W2147273009 @default.
- W2078412111 cites W2149250436 @default.
- W2078412111 cites W2152207188 @default.
- W2078412111 cites W2153925347 @default.
- W2078412111 cites W2159532448 @default.
- W2078412111 cites W2161481747 @default.
- W2078412111 cites W2163337675 @default.
- W2078412111 cites W2164125797 @default.
- W2078412111 cites W2164958133 @default.
- W2078412111 cites W2170936621 @default.
- W2078412111 cites W2172253185 @default.
- W2078412111 cites W2209939113 @default.
- W2078412111 cites W2314816945 @default.
- W2078412111 cites W2342744565 @default.
- W2078412111 cites W2413980390 @default.