FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078412181> ?p ?o ?g. }

• W2078412181 endingPage "142" @default.
• W2078412181 startingPage "133" @default.
• W2078412181 abstract "Lipoprotein lipase (LPL) is a rate-limiting enzyme that hydrolyzes circulating triglyceride-rich lipoproteins such as very low-density lipoproteins and chylomicrons. A decrease in LPL activity is associated with an increase in plasma triglycerides (TG) and a decrease in plasma high-density lipoprotein cholesterol (HDL-C). The increase in plasma TG and decrease in plasma HDL-C are risk factors for cardiovascular disease. Tsutsumi et al. hypothesized that elevating LPL activity would cause a reduction of plasma TG and an increase in plasma HDL-C, resulting in protection against the development of atherosclerosis. To test this hypothesis, Otsuka Pharmaceutical Factory, Inc. synthesized the LPL activator NO-1886. NO-1886 increased LPL mRNA and LPL activity in adipose tissue, myocardium and skeletal muscle, resulting in an elevation of postheparin plasma LPL activity and LPL mass in rats. NO-1886 also decreased plasma TG concentration and caused a concomitant rise in plasma HDL-C. Long-term administration of NO-1886 to rats and rabbits with experimental atherosclerosis inhibited the development of atherosclerotic lesions in coronary arteries and aortas. Multiple regression analysis suggested that the increase in plasma HDL-C and the decrease in plasma TG protect from atherosclerosis. The atherogenic lipid profile is changed to an antiatherogenic profile by increasing LPL activity, resulting in protection from atherosclerosis. Therefore, the LPL activator NO-1886 or other possible LPL activating agents are potentially beneficial for the treatment of hypertriglyceridemia, hypo-HDL cholesterolemia, and protection from atherosclerosis." @default.
• W2078412181 created "2016-06-24" @default.
• W2078412181 creator A5017425633 @default.
• W2078412181 creator A5060976698 @default.
• W2078412181 date "2006-06-07" @default.
• W2078412181 modified "2023-09-26" @default.
• W2078412181 title "Lipoprotein Lipase Activator NO-1886" @default.
• W2078412181 cites W1423486763 @default.
• W2078412181 cites W1568336232 @default.
• W2078412181 cites W1925248176 @default.
• W2078412181 cites W1967041734 @default.
• W2078412181 cites W1972388850 @default.
• W2078412181 cites W1979352055 @default.
• W2078412181 cites W1983330637 @default.
• W2078412181 cites W1988614543 @default.
• W2078412181 cites W1992335027 @default.
• W2078412181 cites W2005337337 @default.
• W2078412181 cites W2006705370 @default.
• W2078412181 cites W2022676255 @default.
• W2078412181 cites W2036153812 @default.
• W2078412181 cites W2044677374 @default.
• W2078412181 cites W2047070188 @default.
• W2078412181 cites W2051743869 @default.
• W2078412181 cites W2060776198 @default.
• W2078412181 cites W2064481606 @default.
• W2078412181 cites W2073009604 @default.
• W2078412181 cites W2074609350 @default.
• W2078412181 cites W2075817653 @default.
• W2078412181 cites W2076394051 @default.
• W2078412181 cites W2078941115 @default.
• W2078412181 cites W2088567842 @default.
• W2078412181 cites W2092504022 @default.
• W2078412181 cites W2113784056 @default.
• W2078412181 cites W2116748863 @default.
• W2078412181 cites W2120870247 @default.
• W2078412181 cites W2123769648 @default.
• W2078412181 cites W2126568311 @default.
• W2078412181 cites W2145026793 @default.
• W2078412181 cites W2146381965 @default.
• W2078412181 cites W2151540642 @default.
• W2078412181 cites W2155238815 @default.
• W2078412181 cites W2155253877 @default.
• W2078412181 cites W4243946355 @default.
• W2078412181 doi "https://doi.org/10.1111/j.1527-3466.2003.tb00111.x" @default.
• W2078412181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12847564" @default.
• W2078412181 hasPublicationYear "2006" @default.
• W2078412181 type Work @default.
• W2078412181 sameAs 2078412181 @default.
• W2078412181 citedByCount "20" @default.
• W2078412181 countsByYear W20784121812012 @default.
• W2078412181 countsByYear W20784121812014 @default.
• W2078412181 countsByYear W20784121812015 @default.
• W2078412181 countsByYear W20784121812017 @default.
• W2078412181 countsByYear W20784121812018 @default.
• W2078412181 countsByYear W20784121812020 @default.
• W2078412181 countsByYear W20784121812021 @default.
• W2078412181 crossrefType "journal-article" @default.
• W2078412181 hasAuthorship W2078412181A5017425633 @default.
• W2078412181 hasAuthorship W2078412181A5060976698 @default.
• W2078412181 hasBestOaLocation W20784121811 @default.
• W2078412181 hasConcept C11772777 @default.
• W2078412181 hasConcept C126322002 @default.
• W2078412181 hasConcept C134018914 @default.
• W2078412181 hasConcept C171089720 @default.
• W2078412181 hasConcept C185592680 @default.
• W2078412181 hasConcept C2776919658 @default.
• W2078412181 hasConcept C2778163477 @default.
• W2078412181 hasConcept C2778913445 @default.
• W2078412181 hasConcept C2780072125 @default.
• W2078412181 hasConcept C71924100 @default.
• W2078412181 hasConcept C8243546 @default.
• W2078412181 hasConcept C86803240 @default.
• W2078412181 hasConcept C94879076 @default.
• W2078412181 hasConceptScore W2078412181C11772777 @default.
• W2078412181 hasConceptScore W2078412181C126322002 @default.
• W2078412181 hasConceptScore W2078412181C134018914 @default.
• W2078412181 hasConceptScore W2078412181C171089720 @default.
• W2078412181 hasConceptScore W2078412181C185592680 @default.
• W2078412181 hasConceptScore W2078412181C2776919658 @default.
• W2078412181 hasConceptScore W2078412181C2778163477 @default.
• W2078412181 hasConceptScore W2078412181C2778913445 @default.
• W2078412181 hasConceptScore W2078412181C2780072125 @default.
• W2078412181 hasConceptScore W2078412181C71924100 @default.
• W2078412181 hasConceptScore W2078412181C8243546 @default.
• W2078412181 hasConceptScore W2078412181C86803240 @default.
• W2078412181 hasConceptScore W2078412181C94879076 @default.
• W2078412181 hasIssue "2" @default.
• W2078412181 hasLocation W20784121811 @default.
• W2078412181 hasLocation W20784121812 @default.
• W2078412181 hasOpenAccess W2078412181 @default.
• W2078412181 hasPrimaryLocation W20784121811 @default.
• W2078412181 hasRelatedWork W1973141976 @default.
• W2078412181 hasRelatedWork W2004613114 @default.
• W2078412181 hasRelatedWork W2020817737 @default.
• W2078412181 hasRelatedWork W2048544365 @default.
• W2078412181 hasRelatedWork W2068768710 @default.
• W2078412181 hasRelatedWork W2142407152 @default.
• W2078412181 hasRelatedWork W2144943167 @default.

• next