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• W2078412457 endingPage "73" @default.
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• W2078412457 abstract "In response to genotoxic stress, eukaryotic cells activate the DNA damage response (DDR), a series of pathways that coordinate cell cycle arrest and DNA repair to prevent deleterious mutations. In addition, cells possess checkpoint mechanisms that prevent aneuploidy by regulating the number of centrosomes and spindle assembly. Among these mechanisms, ubiquitin-mediated degradation of key proteins has an important role in the regulation of the DDR, centrosome duplication and chromosome segregation. This review discusses the functions of a group of ubiquitin ligases, the SCF (SKP1-CUL1-F-box protein) family, in the maintenance of genome stability. Given that general proteasome inhibitors are currently used as anticancer agents, a better understanding of the ubiquitylation of specific targets by specific ubiquitin ligases may result in improved cancer therapeutics. In response to genotoxic stress, eukaryotic cells activate the DNA damage response (DDR), a series of pathways that coordinate cell cycle arrest and DNA repair to prevent deleterious mutations. In addition, cells possess checkpoint mechanisms that prevent aneuploidy by regulating the number of centrosomes and spindle assembly. Among these mechanisms, ubiquitin-mediated degradation of key proteins has an important role in the regulation of the DDR, centrosome duplication and chromosome segregation. This review discusses the functions of a group of ubiquitin ligases, the SCF (SKP1-CUL1-F-box protein) family, in the maintenance of genome stability. Given that general proteasome inhibitors are currently used as anticancer agents, a better understanding of the ubiquitylation of specific targets by specific ubiquitin ligases may result in improved cancer therapeutics. cells that have an abnormal number of chromosomes. the anaphase-promoting complex/cyclosome (APC/C) can use two different adaptor proteins, CDC20 and CDH1. The adaptor protein for any one complex is denoted by the superscript. ataxia-telangiectasia mutated protein, a protein kinase that is activated after DNA damage. a protein kinase required for proper mitosis. a protein that binds and activates the Aurora A kinase. It is required for multiple aspects of mitosis. a Raf family protein (see Raf) that is required for RAS pathway signal transduction. one of two adaptors for the APC. one of two adaptors for the APC. a protein that monitors DNA replication and mediates the activation of CHK1 by ATR upon replication stress or DNA damage. the activating subunit for cyclin-dependent kinase complexes using CDK4 or CDK6. Like other cyclins, the levels of cyclin D1 oscillate during the cell cycle, with cyclin D1 levels increasing in G1 phase. proteins that contain a short, 40 amino acid domain that is homologous to a region in cyclin F. This domain mediates the binding of F-box proteins to SKP1, allowing their incorporation into SCF complexes. a bipolar network of tubulin filaments that forms during mitosis and facilitates the segregation of chromosomes into daughter cells. a small ubiquitin-like protein that can be covalently attached to other proteins to modify their functions. NEDD8 is best known for the modification of the cullin family of proteins, which require NEDDylation for their activity. a MAP kinase kinase kinase (MAP3K) that functions downstream of RAS proteins in signal transduction cascades. the RAS protein family (H RAS, K RAS and N RAS) of small GTPase proteins functions in many signal transduction pathways and has a well-defined role in growth control pathways and tumorigenesis. a phosphoserine-binding protein involved in multiple signal transduction cascades." @default.
• W2078412457 created "2016-06-24" @default.
• W2078412457 creator A5034919044 @default.
• W2078412457 creator A5043359170 @default.
• W2078412457 creator A5079652609 @default.
• W2078412457 date "2012-02-01" @default.
• W2078412457 modified "2023-10-01" @default.
• W2078412457 title "SCF ubiquitin ligases in the maintenance of genome stability" @default.
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• W2078412457 doi "https://doi.org/10.1016/j.tibs.2011.10.004" @default.
• W2078412457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3278546" @default.
• W2078412457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22099186" @default.
• W2078412457 hasPublicationYear "2012" @default.
• W2078412457 type Work @default.
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