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• W2078414009 endingPage "e53372" @default.
• W2078414009 startingPage "e53372" @default.
• W2078414009 abstract "Human amniotic fluid contains cells that potentially have important stem cell characteristics, yet the programs controlling their developmental potency are unclear. Here, we provide evidence that amniocytes derived from multiple patients are marked by heterogeneity and variability in expression levels of pluripotency markers. Clonal analysis from multiple patients indicates that amniocytes have large pools of self-renewing cells that have an inherent property to give rise to a distinct amniocyte phenotype with a heterogeneity of pluripotent markers. Significant to their therapeutic potential, genome-wide profiles are distinct at different gestational ages and times in culture, but do not differ between genders. Based on hierarchical clustering and differential expression analyses of the entire transcriptome, amniocytes express canonical regulators associated with pluripotency and stem cell repression. Their profiles are distinct from human embryonic stem cells (ESCs), induced-pluripotent stem cells (iPSCs), and newborn foreskin fibroblasts. Amniocytes have a complex molecular signature, coexpressing trophoblastic, ectodermal, mesodermal, and endodermal cell-type-specific regulators. In contrast to the current view of the ground state of stem cells, ESCs and iPSCs also express high levels of a wide range of cell-type-specific regulators. The coexpression of multilineage differentiation markers combined with the strong expression of a subset of ES cell repressors in amniocytes suggests that these cells have a distinct phenotype that is unlike any other known cell-type or lineage." @default.
• W2078414009 created "2016-06-24" @default.
• W2078414009 creator A5000966336 @default.
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• W2078414009 creator A5083178799 @default.
• W2078414009 creator A5087759212 @default.
• W2078414009 date "2013-01-10" @default.
• W2078414009 modified "2023-09-26" @default.
• W2078414009 title "Genome-Wide Analysis Reveals the Unique Stem Cell Identity of Human Amniocytes" @default.
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• W2078414009 doi "https://doi.org/10.1371/journal.pone.0053372" @default.
• W2078414009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3542377" @default.
• W2078414009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23326421" @default.
• W2078414009 hasPublicationYear "2013" @default.
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