FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078416937> ?p ?o ?g. }

• W2078416937 endingPage "70" @default.
• W2078416937 startingPage "59" @default.
• W2078416937 abstract "Embryonic mesenchymal feeders produce paracrine signals requisite for ex vivo survival and expansion of hepatic progenitors. The signals consist of a subset of soluble factors found in conditioned medium, and a subset of insoluble factors found in extracellular matrix that include collagens and basal adhesion molecules. We have identified key matrix components required for ex vivo maintenance of human hepatic progenitors produced by biologically active feeders. These components are similar to those found in zone 1 of the liver acinus (e.g., space of Disse) between layers of parenchyma and endothelia. Within these layers are transition chemistry matrix gradients, from zone 1 to zone 3. Use of purified zone 1 matrix components enables attachment and expansion of human hepatic progenitors independent of feeders. Cells aggregated into spheroid-like structures on laminin or spread into monolayers on type III or IV collagens. Contrastingly, a zone 3 matrix component, type I collagen, elicited growth arrest and differentiation. Another zone 3 matrix component, fibronectin, inhibited attachment. Use of specific matrix components, along with soluble paracrine signals from feeders, should enable one to maintain hepatic progenitors ex vivo without feeders and under wholly defined conditions." @default.
• W2078416937 created "2016-06-24" @default.
• W2078416937 creator A5025165719 @default.
• W2078416937 creator A5054542235 @default.
• W2078416937 creator A5066874371 @default.
• W2078416937 creator A5088497410 @default.
• W2078416937 date "2008-01-01" @default.
• W2078416937 modified "2023-10-02" @default.
• W2078416937 title "Gradients in the Liver's Extracellular Matrix Chemistry from Periportal to Pericentral Zones: Influence on Human Hepatic Progenitors" @default.
• W2078416937 cites W1786861597 @default.
• W2078416937 cites W1969470610 @default.
• W2078416937 cites W1976183817 @default.
• W2078416937 cites W1986289947 @default.
• W2078416937 cites W1994736606 @default.
• W2078416937 cites W2017731907 @default.
• W2078416937 cites W2022487205 @default.
• W2078416937 cites W2030191840 @default.
• W2078416937 cites W2050261356 @default.
• W2078416937 cites W2061717797 @default.
• W2078416937 cites W2068888264 @default.
• W2078416937 cites W2086462062 @default.
• W2078416937 cites W2094963584 @default.
• W2078416937 cites W2139966914 @default.
• W2078416937 cites W2170096497 @default.
• W2078416937 cites W3016634352 @default.
• W2078416937 cites W3175485220 @default.
• W2078416937 cites W350594800 @default.
• W2078416937 cites W4211129387 @default.
• W2078416937 doi "https://doi.org/10.1089/ten.a.2007.0058" @default.
• W2078416937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18333805" @default.
• W2078416937 hasPublicationYear "2008" @default.
• W2078416937 type Work @default.
• W2078416937 sameAs 2078416937 @default.
• W2078416937 citedByCount "67" @default.
• W2078416937 countsByYear W20784169372012 @default.
• W2078416937 countsByYear W20784169372013 @default.
• W2078416937 countsByYear W20784169372014 @default.
• W2078416937 countsByYear W20784169372015 @default.
• W2078416937 countsByYear W20784169372016 @default.
• W2078416937 countsByYear W20784169372017 @default.
• W2078416937 countsByYear W20784169372018 @default.
• W2078416937 countsByYear W20784169372019 @default.
• W2078416937 countsByYear W20784169372020 @default.
• W2078416937 countsByYear W20784169372021 @default.
• W2078416937 countsByYear W20784169372022 @default.
• W2078416937 crossrefType "journal-article" @default.
• W2078416937 hasAuthorship W2078416937A5025165719 @default.
• W2078416937 hasAuthorship W2078416937A5054542235 @default.
• W2078416937 hasAuthorship W2078416937A5066874371 @default.
• W2078416937 hasAuthorship W2078416937A5088497410 @default.
• W2078416937 hasConcept C106487976 @default.
• W2078416937 hasConcept C15729860 @default.
• W2078416937 hasConcept C170493617 @default.
• W2078416937 hasConcept C185592680 @default.
• W2078416937 hasConcept C189165786 @default.
• W2078416937 hasConcept C190672674 @default.
• W2078416937 hasConcept C201750760 @default.
• W2078416937 hasConcept C202751555 @default.
• W2078416937 hasConcept C26291073 @default.
• W2078416937 hasConcept C2779814568 @default.
• W2078416937 hasConcept C28328180 @default.
• W2078416937 hasConcept C43617362 @default.
• W2078416937 hasConcept C55493867 @default.
• W2078416937 hasConcept C7876069 @default.
• W2078416937 hasConcept C86492073 @default.
• W2078416937 hasConcept C86803240 @default.
• W2078416937 hasConcept C95444343 @default.
• W2078416937 hasConceptScore W2078416937C106487976 @default.
• W2078416937 hasConceptScore W2078416937C15729860 @default.
• W2078416937 hasConceptScore W2078416937C170493617 @default.
• W2078416937 hasConceptScore W2078416937C185592680 @default.
• W2078416937 hasConceptScore W2078416937C189165786 @default.
• W2078416937 hasConceptScore W2078416937C190672674 @default.
• W2078416937 hasConceptScore W2078416937C201750760 @default.
• W2078416937 hasConceptScore W2078416937C202751555 @default.
• W2078416937 hasConceptScore W2078416937C26291073 @default.
• W2078416937 hasConceptScore W2078416937C2779814568 @default.
• W2078416937 hasConceptScore W2078416937C28328180 @default.
• W2078416937 hasConceptScore W2078416937C43617362 @default.
• W2078416937 hasConceptScore W2078416937C55493867 @default.
• W2078416937 hasConceptScore W2078416937C7876069 @default.
• W2078416937 hasConceptScore W2078416937C86492073 @default.
• W2078416937 hasConceptScore W2078416937C86803240 @default.
• W2078416937 hasConceptScore W2078416937C95444343 @default.
• W2078416937 hasIssue "1" @default.
• W2078416937 hasLocation W20784169371 @default.
• W2078416937 hasLocation W20784169372 @default.
• W2078416937 hasOpenAccess W2078416937 @default.
• W2078416937 hasPrimaryLocation W20784169371 @default.
• W2078416937 hasRelatedWork W1971460289 @default.
• W2078416937 hasRelatedWork W1996188576 @default.
• W2078416937 hasRelatedWork W2078416937 @default.
• W2078416937 hasRelatedWork W2106761248 @default.
• W2078416937 hasRelatedWork W2423807530 @default.
• W2078416937 hasRelatedWork W2731238656 @default.
• W2078416937 hasRelatedWork W2949268325 @default.
• W2078416937 hasRelatedWork W2983774967 @default.
• W2078416937 hasRelatedWork W3173940023 @default.

• next