FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078421402> ?p ?o ?g. }

• W2078421402 endingPage "143" @default.
• W2078421402 startingPage "138" @default.
• W2078421402 abstract "Radiotherapy is a widely used treatment for many tumors. Combination therapy using anti-angiogenic agents and radiation has shown promise; however, these combined therapies are reported to have many limitations in clinical trials. Here, we show that radiation transformed tumor endothelial cells (ECs) to fibroblasts, resulting in reduced vascular endothelial growth factor (VEGF) response and increased Snail1, Twist1, Type I collagen, and transforming growth factor (TGF)-β release. Irradiation of radioresistant Lewis lung carcinoma (LLC) tumors greater than 250 mm³ increased collagen levels, particularly in large tumor vessels. Furthermore, concomitant sunitinib therapy did not show a significant difference in tumor inhibition versus radiation alone. Thus, we evaluated multimodal therapy that combined pirfenidone, an inhibitor of TGF-induced collagen production, with radiation and sunitinib treatment. This trimodal therapy significantly reduced tumor growth, as compared to radiation alone. Immunohistochemical analysis revealed that radiation-induced collagen deposition and tumor microvessel density were significantly reduced with trimodal therapy, as compared to radiation alone. These data suggest that combined therapy using pirfenidone may modulate the radiation-altered tumor microenvironment, thereby enhancing the efficacy of radiation therapy and concurrent chemotherapy." @default.
• W2078421402 created "2016-06-24" @default.
• W2078421402 creator A5013198714 @default.
• W2078421402 creator A5022162451 @default.
• W2078421402 creator A5024801895 @default.
• W2078421402 creator A5030998316 @default.
• W2078421402 creator A5083074214 @default.
• W2078421402 date "2015-06-01" @default.
• W2078421402 modified "2023-10-16" @default.
• W2078421402 title "Pirfenidone enhances the efficacy of combined radiation and sunitinib therapy" @default.
• W2078421402 cites W1575588863 @default.
• W2078421402 cites W1970644541 @default.
• W2078421402 cites W1990549345 @default.
• W2078421402 cites W1992058715 @default.
• W2078421402 cites W1992866376 @default.
• W2078421402 cites W1993849812 @default.
• W2078421402 cites W1997538876 @default.
• W2078421402 cites W2002689409 @default.
• W2078421402 cites W2003621633 @default.
• W2078421402 cites W2011099319 @default.
• W2078421402 cites W2018640022 @default.
• W2078421402 cites W2020893145 @default.
• W2078421402 cites W2025242995 @default.
• W2078421402 cites W2029425171 @default.
• W2078421402 cites W2039155298 @default.
• W2078421402 cites W2040042000 @default.
• W2078421402 cites W2042006898 @default.
• W2078421402 cites W2077715347 @default.
• W2078421402 cites W2085300152 @default.
• W2078421402 cites W2102944868 @default.
• W2078421402 cites W2118096781 @default.
• W2078421402 cites W2124726866 @default.
• W2078421402 cites W2132566055 @default.
• W2078421402 cites W2138310931 @default.
• W2078421402 cites W2139593382 @default.
• W2078421402 cites W2149456801 @default.
• W2078421402 cites W2153331460 @default.
• W2078421402 cites W2160657814 @default.
• W2078421402 cites W2212472250 @default.
• W2078421402 cites W2315538569 @default.
• W2078421402 cites W2351274769 @default.
• W2078421402 cites W3081996972 @default.
• W2078421402 doi "https://doi.org/10.1016/j.bbrc.2015.04.107" @default.
• W2078421402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25935484" @default.
• W2078421402 hasPublicationYear "2015" @default.
• W2078421402 type Work @default.
• W2078421402 sameAs 2078421402 @default.
• W2078421402 citedByCount "11" @default.
• W2078421402 countsByYear W20784214022016 @default.
• W2078421402 countsByYear W20784214022017 @default.
• W2078421402 countsByYear W20784214022018 @default.
• W2078421402 countsByYear W20784214022019 @default.
• W2078421402 countsByYear W20784214022020 @default.
• W2078421402 countsByYear W20784214022021 @default.
• W2078421402 countsByYear W20784214022022 @default.
• W2078421402 crossrefType "journal-article" @default.
• W2078421402 hasAuthorship W2078421402A5013198714 @default.
• W2078421402 hasAuthorship W2078421402A5022162451 @default.
• W2078421402 hasAuthorship W2078421402A5024801895 @default.
• W2078421402 hasAuthorship W2078421402A5030998316 @default.
• W2078421402 hasAuthorship W2078421402A5083074214 @default.
• W2078421402 hasConcept C121608353 @default.
• W2078421402 hasConcept C126322002 @default.
• W2078421402 hasConcept C142724271 @default.
• W2078421402 hasConcept C167734588 @default.
• W2078421402 hasConcept C2776107976 @default.
• W2078421402 hasConcept C2776999253 @default.
• W2078421402 hasConcept C2777025900 @default.
• W2078421402 hasConcept C2777714996 @default.
• W2078421402 hasConcept C2777847059 @default.
• W2078421402 hasConcept C2778341716 @default.
• W2078421402 hasConcept C2779013556 @default.
• W2078421402 hasConcept C2779384505 @default.
• W2078421402 hasConcept C2779490328 @default.
• W2078421402 hasConcept C2779832356 @default.
• W2078421402 hasConcept C3020616263 @default.
• W2078421402 hasConcept C502942594 @default.
• W2078421402 hasConcept C509974204 @default.
• W2078421402 hasConcept C58962609 @default.
• W2078421402 hasConcept C71924100 @default.
• W2078421402 hasConceptScore W2078421402C121608353 @default.
• W2078421402 hasConceptScore W2078421402C126322002 @default.
• W2078421402 hasConceptScore W2078421402C142724271 @default.
• W2078421402 hasConceptScore W2078421402C167734588 @default.
• W2078421402 hasConceptScore W2078421402C2776107976 @default.
• W2078421402 hasConceptScore W2078421402C2776999253 @default.
• W2078421402 hasConceptScore W2078421402C2777025900 @default.
• W2078421402 hasConceptScore W2078421402C2777714996 @default.
• W2078421402 hasConceptScore W2078421402C2777847059 @default.
• W2078421402 hasConceptScore W2078421402C2778341716 @default.
• W2078421402 hasConceptScore W2078421402C2779013556 @default.
• W2078421402 hasConceptScore W2078421402C2779384505 @default.
• W2078421402 hasConceptScore W2078421402C2779490328 @default.
• W2078421402 hasConceptScore W2078421402C2779832356 @default.
• W2078421402 hasConceptScore W2078421402C3020616263 @default.
• W2078421402 hasConceptScore W2078421402C502942594 @default.
• W2078421402 hasConceptScore W2078421402C509974204 @default.
• W2078421402 hasConceptScore W2078421402C58962609 @default.

• next