Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078421869> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2078421869 endingPage "4492" @default.
- W2078421869 startingPage "4487" @default.
- W2078421869 abstract "Pathways of ethanol elimination in alcohol dehydrogenase (ADH)-positive and -negative deermice were studied using the catalase inhibitor, 3-amino-1,2,4-triazole. To verify that aminotriazole inhibited catalase effectively, the characteristic decrease in catalase-H 2 O 2 which occurs in saline-treated controls when ethanol is peroxidized was monitored at 660−640 nm in perfused deermouse livers. Following 1.5 hr of pretreatment with aminotriazole (1.5 g/kg), the peroxidatic activity of catalase measured in vitro was inhibited by greater than 99%. Under these conditions, ethanol did not decrease catalase-H 2 O 2 in perfused livers, indicating that catalase was inhibited. Ethanol and aniline oxidation by microsomes were also inhibited by about 67–90% after 1.5 hr of pretreatment with aminotriazole. In ADH-positive deermice, pretreatment with aminotriazole for 1.5 hr prior to injection of ethanol (2.0 g/kg) decreased rates of ethanol elimination in vivo from 13.2 ± 0.8 to 10.2 ± 0.4 mmoles/kg/hr. In ADH-negative deermice, similar treatment decreased rates of ethanol elimination in vivo from 4.5 ± 0.4 to 1.1 ± 0.6 mmoles/kg/hr. Following pretreatment with aminotriazole (1.0 g/kg) for 6 hr, rates of ethanol elimination in ADH-negative deermice returned to near basal values. Under these conditions, the peroxidatic activity of catalase measured in vitro and the ethanol-dependent decrease in catalase-H 2 O 2 in perfused livers also returned to near basal levels; however, the oxidation of ethanol by cytochrome P-450 was inhibited completely. It is concluded, therefore, that time of pretreatment with aminotriazole is an important variable which must be controlled carefully to inhibit catalase completely. Since catalase was active while cytochrome P-450 was not following 6 hr of pretreatment with aminotriazole, it is concluded that ethanol elimination occurs predominantly via catalase-H 2 O 2 in ADH-negative deermice under these conditions." @default.
- W2078421869 created "2016-06-24" @default.
- W2078421869 creator A5005136009 @default.
- W2078421869 creator A5031650750 @default.
- W2078421869 creator A5049757264 @default.
- W2078421869 creator A5054088423 @default.
- W2078421869 creator A5081636513 @default.
- W2078421869 date "1986-12-01" @default.
- W2078421869 modified "2023-09-26" @default.
- W2078421869 title "Catalase-dependent ethanol metabolism in vivo in deermice lacking alcohol dehydrogenase" @default.
- W2078421869 cites W1496968467 @default.
- W2078421869 cites W1506043065 @default.
- W2078421869 cites W1533807800 @default.
- W2078421869 cites W1578509685 @default.
- W2078421869 cites W1593453854 @default.
- W2078421869 cites W1806194750 @default.
- W2078421869 cites W1815767345 @default.
- W2078421869 cites W1865753174 @default.
- W2078421869 cites W1967347259 @default.
- W2078421869 cites W1970221421 @default.
- W2078421869 cites W1976428457 @default.
- W2078421869 cites W1992201523 @default.
- W2078421869 cites W1995113130 @default.
- W2078421869 cites W2018824603 @default.
- W2078421869 cites W2019012829 @default.
- W2078421869 cites W2034657112 @default.
- W2078421869 cites W2048798574 @default.
- W2078421869 cites W2051788959 @default.
- W2078421869 cites W2058143016 @default.
- W2078421869 cites W2329110182 @default.
- W2078421869 cites W35681168 @default.
- W2078421869 cites W83527592 @default.
- W2078421869 doi "https://doi.org/10.1016/0006-2952(86)90768-9" @default.
- W2078421869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3790167" @default.
- W2078421869 hasPublicationYear "1986" @default.
- W2078421869 type Work @default.
- W2078421869 sameAs 2078421869 @default.
- W2078421869 citedByCount "40" @default.
- W2078421869 countsByYear W20784218692014 @default.
- W2078421869 countsByYear W20784218692016 @default.
- W2078421869 countsByYear W20784218692017 @default.
- W2078421869 countsByYear W20784218692022 @default.
- W2078421869 crossrefType "journal-article" @default.
- W2078421869 hasAuthorship W2078421869A5005136009 @default.
- W2078421869 hasAuthorship W2078421869A5031650750 @default.
- W2078421869 hasAuthorship W2078421869A5049757264 @default.
- W2078421869 hasAuthorship W2078421869A5054088423 @default.
- W2078421869 hasAuthorship W2078421869A5081636513 @default.
- W2078421869 hasConcept C126322002 @default.
- W2078421869 hasConcept C134018914 @default.
- W2078421869 hasConcept C150903083 @default.
- W2078421869 hasConcept C181199279 @default.
- W2078421869 hasConcept C185592680 @default.
- W2078421869 hasConcept C207001950 @default.
- W2078421869 hasConcept C2777344606 @default.
- W2078421869 hasConcept C2778979269 @default.
- W2078421869 hasConcept C2780161600 @default.
- W2078421869 hasConcept C2781066024 @default.
- W2078421869 hasConcept C55493867 @default.
- W2078421869 hasConcept C71924100 @default.
- W2078421869 hasConcept C86803240 @default.
- W2078421869 hasConcept C87644729 @default.
- W2078421869 hasConceptScore W2078421869C126322002 @default.
- W2078421869 hasConceptScore W2078421869C134018914 @default.
- W2078421869 hasConceptScore W2078421869C150903083 @default.
- W2078421869 hasConceptScore W2078421869C181199279 @default.
- W2078421869 hasConceptScore W2078421869C185592680 @default.
- W2078421869 hasConceptScore W2078421869C207001950 @default.
- W2078421869 hasConceptScore W2078421869C2777344606 @default.
- W2078421869 hasConceptScore W2078421869C2778979269 @default.
- W2078421869 hasConceptScore W2078421869C2780161600 @default.
- W2078421869 hasConceptScore W2078421869C2781066024 @default.
- W2078421869 hasConceptScore W2078421869C55493867 @default.
- W2078421869 hasConceptScore W2078421869C71924100 @default.
- W2078421869 hasConceptScore W2078421869C86803240 @default.
- W2078421869 hasConceptScore W2078421869C87644729 @default.
- W2078421869 hasIssue "24" @default.
- W2078421869 hasLocation W20784218691 @default.
- W2078421869 hasLocation W20784218692 @default.
- W2078421869 hasOpenAccess W2078421869 @default.
- W2078421869 hasPrimaryLocation W20784218691 @default.
- W2078421869 hasRelatedWork W151160195 @default.
- W2078421869 hasRelatedWork W1891973497 @default.
- W2078421869 hasRelatedWork W1976349950 @default.
- W2078421869 hasRelatedWork W1987694780 @default.
- W2078421869 hasRelatedWork W1988150902 @default.
- W2078421869 hasRelatedWork W2056903658 @default.
- W2078421869 hasRelatedWork W2090271380 @default.
- W2078421869 hasRelatedWork W2095594987 @default.
- W2078421869 hasRelatedWork W2161230163 @default.
- W2078421869 hasRelatedWork W2413903429 @default.
- W2078421869 hasVolume "35" @default.
- W2078421869 isParatext "false" @default.
- W2078421869 isRetracted "false" @default.
- W2078421869 magId "2078421869" @default.
- W2078421869 workType "article" @default.