FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078430129> ?p ?o ?g. }

• W2078430129 endingPage "626" @default.
• W2078430129 startingPage "617" @default.
• W2078430129 abstract "The aim of the present work was to identify the material attributes and process parameters of a dosator-nozzle capsule filling machine that are critical in low-fill weight capsule filling for inhalation therapies via hard-gelatin capsules. Twelve powders, mostly inhalation carriers, some fines and one proprietary active pharmaceutical ingredient (API), were carefully characterized and filled into size 3 capsules. Since different process conditions are required to fill capsules with powders that have very different material attributes, the powders were divided into two groups. A design of experiments (DOE) based exclusively on process parameters was developed for each group, to identify the critical material attributes (CMA) and critical process parameters (CPP). The fill weight (4–45 mg) of the group I powders (larger particles, higher density, better flowability and less cohesion) correlated with the nozzle diameter (1.9–3.4 mm), the dosing chamber length (2.5–5 mm), the powder layer depth (5–12.5 mm) and the powder density (bulk and tapped density). The RSDs were acceptable in most cases, even for very low doses. The fill weight (1.5–21 mg) of group II powders (very fine and low dense particles with a particle size <10 μm, poor flowability and higher cohesion) depended also on the nozzle diameter (1.9–2.8 mm), the dosing chamber length (2.5–5 mm) and the powder layer depth (5–10 mm), albeit in a different way, indicating that for these powders dosator filling was not volumetric. Moreover, frictional (wall friction angle) and powder-flow characteristics (bulk density and basic flowability energy) have an influence on the mass. Thus, in summary, group I and group II powders can be filled successfully via dosator systems at low fill weights. However, the group II powders were more challenging to fill, especially without automated process control. This study is the first scientific qualification of dosator nozzles for low-fill weight (1–45 mg) capsule filling." @default.
• W2078430129 created "2016-06-24" @default.
• W2078430129 creator A5017620070 @default.
• W2078430129 creator A5023848615 @default.
• W2078430129 creator A5032152919 @default.
• W2078430129 creator A5036109780 @default.
• W2078430129 creator A5037916347 @default.
• W2078430129 creator A5083613172 @default.
• W2078430129 creator A5090360163 @default.
• W2078430129 date "2014-10-01" @default.
• W2078430129 modified "2023-10-10" @default.
• W2078430129 title "Low-dose capsule filling of inhalation products: Critical material attributes and process parameters" @default.
• W2078430129 cites W1983222220 @default.
• W2078430129 cites W1984246568 @default.
• W2078430129 cites W1988023401 @default.
• W2078430129 cites W1989339935 @default.
• W2078430129 cites W1989622438 @default.
• W2078430129 cites W1992547859 @default.
• W2078430129 cites W2002257670 @default.
• W2078430129 cites W2002867330 @default.
• W2078430129 cites W2006759883 @default.
• W2078430129 cites W2010215415 @default.
• W2078430129 cites W2010952801 @default.
• W2078430129 cites W2024820988 @default.
• W2078430129 cites W2025351758 @default.
• W2078430129 cites W2025918816 @default.
• W2078430129 cites W2035452178 @default.
• W2078430129 cites W2042765704 @default.
• W2078430129 cites W2046750232 @default.
• W2078430129 cites W2050769074 @default.
• W2078430129 cites W2051881319 @default.
• W2078430129 cites W2053396595 @default.
• W2078430129 cites W2053923955 @default.
• W2078430129 cites W2056301226 @default.
• W2078430129 cites W2058160833 @default.
• W2078430129 cites W2065591856 @default.
• W2078430129 cites W2074768025 @default.
• W2078430129 cites W2084194047 @default.
• W2078430129 cites W2089589841 @default.
• W2078430129 cites W2093007030 @default.
• W2078430129 cites W2094389346 @default.
• W2078430129 cites W2095391531 @default.
• W2078430129 cites W2108837856 @default.
• W2078430129 cites W2121854834 @default.
• W2078430129 cites W2130384587 @default.
• W2078430129 doi "https://doi.org/10.1016/j.ijpharm.2014.07.050" @default.
• W2078430129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25087508" @default.
• W2078430129 hasPublicationYear "2014" @default.
• W2078430129 type Work @default.
• W2078430129 sameAs 2078430129 @default.
• W2078430129 citedByCount "41" @default.
• W2078430129 countsByYear W20784301292015 @default.
• W2078430129 countsByYear W20784301292016 @default.
• W2078430129 countsByYear W20784301292017 @default.
• W2078430129 countsByYear W20784301292018 @default.
• W2078430129 countsByYear W20784301292019 @default.
• W2078430129 countsByYear W20784301292020 @default.
• W2078430129 countsByYear W20784301292021 @default.
• W2078430129 countsByYear W20784301292022 @default.
• W2078430129 countsByYear W20784301292023 @default.
• W2078430129 crossrefType "journal-article" @default.
• W2078430129 hasAuthorship W2078430129A5017620070 @default.
• W2078430129 hasAuthorship W2078430129A5023848615 @default.
• W2078430129 hasAuthorship W2078430129A5032152919 @default.
• W2078430129 hasAuthorship W2078430129A5036109780 @default.
• W2078430129 hasAuthorship W2078430129A5037916347 @default.
• W2078430129 hasAuthorship W2078430129A5083613172 @default.
• W2078430129 hasAuthorship W2078430129A5090360163 @default.
• W2078430129 hasConcept C104054115 @default.
• W2078430129 hasConcept C105341887 @default.
• W2078430129 hasConcept C127413603 @default.
• W2078430129 hasConcept C159985019 @default.
• W2078430129 hasConcept C178790620 @default.
• W2078430129 hasConcept C185592680 @default.
• W2078430129 hasConcept C187530423 @default.
• W2078430129 hasConcept C192562407 @default.
• W2078430129 hasConcept C202444582 @default.
• W2078430129 hasConcept C2778778583 @default.
• W2078430129 hasConcept C2778823387 @default.
• W2078430129 hasConcept C33923547 @default.
• W2078430129 hasConcept C42360764 @default.
• W2078430129 hasConcept C55493867 @default.
• W2078430129 hasConcept C56200935 @default.
• W2078430129 hasConcept C5961521 @default.
• W2078430129 hasConcept C59822182 @default.
• W2078430129 hasConcept C78519656 @default.
• W2078430129 hasConcept C86803240 @default.
• W2078430129 hasConceptScore W2078430129C104054115 @default.
• W2078430129 hasConceptScore W2078430129C105341887 @default.
• W2078430129 hasConceptScore W2078430129C127413603 @default.
• W2078430129 hasConceptScore W2078430129C159985019 @default.
• W2078430129 hasConceptScore W2078430129C178790620 @default.
• W2078430129 hasConceptScore W2078430129C185592680 @default.
• W2078430129 hasConceptScore W2078430129C187530423 @default.
• W2078430129 hasConceptScore W2078430129C192562407 @default.
• W2078430129 hasConceptScore W2078430129C202444582 @default.
• W2078430129 hasConceptScore W2078430129C2778778583 @default.
• W2078430129 hasConceptScore W2078430129C2778823387 @default.

• next