FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078432923> ?p ?o ?g. }

• W2078432923 endingPage "78" @default.
• W2078432923 startingPage "72" @default.
• W2078432923 abstract "The role of matrix metalloproteinases in parathyroid hormone (PTH)-induced bone resorption was assayed using a fetal rat limb bone culture system. Cotreatment of bones with PTH and recombinant inhibitor of metalloproteinases, TIMP-1, in vitro, inhibited the PTH-stimulated 45Ca release from the limb bones without affecting β-glucuronidase release. TIMP-1 was fully effective when added during only the final 24 h of a 72 h culture with PTH but was ineffective when added for only the first 24 h of the 72 h culture. In contrast, calcitonin (CT) was effective when added for either the first 24 or the final 24 h of the culture. Using in situ hybridization, the mRNA for collagenase was detected in mononuclear cells of cultured bone. Treatment of the bones with PTH resulted in an increase in the number of cells producing collagenase mRNA, some of which had osteoclastic morphology. PTH also caused a dramatic induction of the mRNA for the 92-kD gelatinase B metalloproteinase in both mononuclear and osteoclastic cells. There was no detectable mRNA for the metalloproteinases stromelysin-1, stromelysin-2, or matrilysin in PTH-treated or control cultures. These results suggest that PTH-induced bone resorption is mediated, at least in part, by the induction of collagenase and gelatinase B mRNA in bone cells." @default.
• W2078432923 created "2016-06-24" @default.
• W2078432923 creator A5006036761 @default.
• W2078432923 creator A5011494202 @default.
• W2078432923 creator A5026523592 @default.
• W2078432923 creator A5049886691 @default.
• W2078432923 creator A5080017108 @default.
• W2078432923 date "2009-12-03" @default.
• W2078432923 modified "2023-09-27" @default.
• W2078432923 title "Parathyroid hormone-induced resorption in fetal rat limb bones is associated with production of the metalloproteinases collagenase and gelatinase B" @default.
• W2078432923 cites W1484740986 @default.
• W2078432923 cites W1511482991 @default.
• W2078432923 cites W1532387473 @default.
• W2078432923 cites W1549954866 @default.
• W2078432923 cites W155136349 @default.
• W2078432923 cites W1591653197 @default.
• W2078432923 cites W1668309971 @default.
• W2078432923 cites W1669342624 @default.
• W2078432923 cites W1894541755 @default.
• W2078432923 cites W1895902281 @default.
• W2078432923 cites W1955836474 @default.
• W2078432923 cites W1967671046 @default.
• W2078432923 cites W1970293798 @default.
• W2078432923 cites W1981905072 @default.
• W2078432923 cites W1984823727 @default.
• W2078432923 cites W1987121453 @default.
• W2078432923 cites W1996706666 @default.
• W2078432923 cites W2008943241 @default.
• W2078432923 cites W2009904653 @default.
• W2078432923 cites W2011807008 @default.
• W2078432923 cites W2019455786 @default.
• W2078432923 cites W2022087872 @default.
• W2078432923 cites W2024602261 @default.
• W2078432923 cites W2030240788 @default.
• W2078432923 cites W2031912912 @default.
• W2078432923 cites W2037447928 @default.
• W2078432923 cites W2039113875 @default.
• W2078432923 cites W2046280437 @default.
• W2078432923 cites W2048169623 @default.
• W2078432923 cites W2049408025 @default.
• W2078432923 cites W2072851420 @default.
• W2078432923 cites W2076413757 @default.
• W2078432923 cites W2080501212 @default.
• W2078432923 cites W2085806876 @default.
• W2078432923 cites W2090896147 @default.
• W2078432923 cites W2095467149 @default.
• W2078432923 cites W2095498651 @default.
• W2078432923 cites W2133562234 @default.
• W2078432923 cites W2395794581 @default.
• W2078432923 cites W2397048910 @default.
• W2078432923 cites W292975853 @default.
• W2078432923 cites W97686824 @default.
• W2078432923 doi "https://doi.org/10.1002/jbmr.5650110111" @default.
• W2078432923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8770699" @default.
• W2078432923 hasPublicationYear "2009" @default.
• W2078432923 type Work @default.
• W2078432923 sameAs 2078432923 @default.
• W2078432923 citedByCount "63" @default.
• W2078432923 countsByYear W20784329232012 @default.
• W2078432923 countsByYear W20784329232013 @default.
• W2078432923 countsByYear W20784329232014 @default.
• W2078432923 countsByYear W20784329232016 @default.
• W2078432923 countsByYear W20784329232017 @default.
• W2078432923 countsByYear W20784329232018 @default.
• W2078432923 countsByYear W20784329232020 @default.
• W2078432923 countsByYear W20784329232022 @default.
• W2078432923 countsByYear W20784329232023 @default.
• W2078432923 crossrefType "journal-article" @default.
• W2078432923 hasAuthorship W2078432923A5006036761 @default.
• W2078432923 hasAuthorship W2078432923A5011494202 @default.
• W2078432923 hasAuthorship W2078432923A5026523592 @default.
• W2078432923 hasAuthorship W2078432923A5049886691 @default.
• W2078432923 hasAuthorship W2078432923A5080017108 @default.
• W2078432923 hasConcept C109523444 @default.
• W2078432923 hasConcept C126322002 @default.
• W2078432923 hasConcept C134018914 @default.
• W2078432923 hasConcept C146562846 @default.
• W2078432923 hasConcept C181199279 @default.
• W2078432923 hasConcept C185592680 @default.
• W2078432923 hasConcept C2776223131 @default.
• W2078432923 hasConcept C2776232661 @default.
• W2078432923 hasConcept C2776747403 @default.
• W2078432923 hasConcept C2778394429 @default.
• W2078432923 hasConcept C2779627488 @default.
• W2078432923 hasConcept C2781208988 @default.
• W2078432923 hasConcept C519063684 @default.
• W2078432923 hasConcept C55493867 @default.
• W2078432923 hasConcept C673006 @default.
• W2078432923 hasConcept C71924100 @default.
• W2078432923 hasConcept C86803240 @default.
• W2078432923 hasConceptScore W2078432923C109523444 @default.
• W2078432923 hasConceptScore W2078432923C126322002 @default.
• W2078432923 hasConceptScore W2078432923C134018914 @default.
• W2078432923 hasConceptScore W2078432923C146562846 @default.
• W2078432923 hasConceptScore W2078432923C181199279 @default.
• W2078432923 hasConceptScore W2078432923C185592680 @default.
• W2078432923 hasConceptScore W2078432923C2776223131 @default.
• W2078432923 hasConceptScore W2078432923C2776232661 @default.

• next