Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078433449> ?p ?o ?g. }
- W2078433449 endingPage "975" @default.
- W2078433449 startingPage "958" @default.
- W2078433449 abstract "Immune activation represents an adaptive reaction triggered by both noxious exogenous (microbes) and endogenous [high mobility group box-1 protein (HMGB1), S100 calcium binding proteins] inducers of inflammation. Cell stress or necrosis lead the release of HMGB1 and S100 proteins in the extracellular compartment where they act as damage-associated molecular pattern molecules (or alarmins) by engaging the receptor for advanced glycation end-products (RAGE). Although the biology of RAGE is dictated by the accumulation of damage-associated molecular pattern molecules at sites of tissue injury, the role of RAGE in mediating antenatal fetal injury remains unknown. First, we studied the relationships at birth between the intensity of human fetal inflammation and sRAGE (an endogenous RAGE antagonist), HMGB1, and S100beta protein. We found significantly lower sRAGE in human fetuses that mounted robust inflammatory responses. HMGB1 levels correlated significantly with levels of interleukin-6 and S100beta in fetal circulation. We then evaluated the levels and areas of tissue expression of RAGE, HMGB1, and S100beta in specific organs of mouse fetuses on E16. Using an animal model of endotoxin-induced fetal damage and preterm birth, we determined that inflammation induces a significant change in expression of RAGE and HMGB1, but not S100beta, at sites of tissue damage. Our findings indicate that RAGE and HMGB1 may be important mediators of cellular injury in fetuses delivered in the setting of inflammation-induced preterm birth." @default.
- W2078433449 created "2016-06-24" @default.
- W2078433449 creator A5000268004 @default.
- W2078433449 creator A5006550776 @default.
- W2078433449 creator A5016134289 @default.
- W2078433449 creator A5017544253 @default.
- W2078433449 creator A5049589443 @default.
- W2078433449 creator A5049642684 @default.
- W2078433449 creator A5051213422 @default.
- W2078433449 creator A5066655749 @default.
- W2078433449 creator A5068713054 @default.
- W2078433449 creator A5074359125 @default.
- W2078433449 creator A5080368882 @default.
- W2078433449 date "2009-09-01" @default.
- W2078433449 modified "2023-10-14" @default.
- W2078433449 title "Characterization of RAGE, HMGB1, and S100β in Inflammation-Induced Preterm Birth and Fetal Tissue Injury" @default.
- W2078433449 cites W1487767039 @default.
- W2078433449 cites W1503258737 @default.
- W2078433449 cites W1577650710 @default.
- W2078433449 cites W1831226188 @default.
- W2078433449 cites W1840001967 @default.
- W2078433449 cites W1948268265 @default.
- W2078433449 cites W1964014168 @default.
- W2078433449 cites W1965112875 @default.
- W2078433449 cites W1967504120 @default.
- W2078433449 cites W1970172365 @default.
- W2078433449 cites W1972404431 @default.
- W2078433449 cites W1972442492 @default.
- W2078433449 cites W1973346925 @default.
- W2078433449 cites W1983088915 @default.
- W2078433449 cites W1984838392 @default.
- W2078433449 cites W1985236743 @default.
- W2078433449 cites W1990612047 @default.
- W2078433449 cites W1993643614 @default.
- W2078433449 cites W1995177733 @default.
- W2078433449 cites W1998713078 @default.
- W2078433449 cites W1999559353 @default.
- W2078433449 cites W2000126618 @default.
- W2078433449 cites W2004266769 @default.
- W2078433449 cites W2004466934 @default.
- W2078433449 cites W2005244375 @default.
- W2078433449 cites W2005640704 @default.
- W2078433449 cites W2008012867 @default.
- W2078433449 cites W2008827565 @default.
- W2078433449 cites W2012772537 @default.
- W2078433449 cites W2014204866 @default.
- W2078433449 cites W2020359241 @default.
- W2078433449 cites W2024524580 @default.
- W2078433449 cites W2026885016 @default.
- W2078433449 cites W2027213205 @default.
- W2078433449 cites W2027364118 @default.
- W2078433449 cites W2031084334 @default.
- W2078433449 cites W2036092834 @default.
- W2078433449 cites W2039839636 @default.
- W2078433449 cites W2042100571 @default.
- W2078433449 cites W2042479115 @default.
- W2078433449 cites W2048514942 @default.
- W2078433449 cites W2048591614 @default.
- W2078433449 cites W2050093406 @default.
- W2078433449 cites W2054556903 @default.
- W2078433449 cites W2065100644 @default.
- W2078433449 cites W2066215889 @default.
- W2078433449 cites W2070459941 @default.
- W2078433449 cites W2071675524 @default.
- W2078433449 cites W2076168945 @default.
- W2078433449 cites W2077708785 @default.
- W2078433449 cites W2079527302 @default.
- W2078433449 cites W2081080245 @default.
- W2078433449 cites W2086643530 @default.
- W2078433449 cites W2088792593 @default.
- W2078433449 cites W2091845372 @default.
- W2078433449 cites W2094349747 @default.
- W2078433449 cites W2114081875 @default.
- W2078433449 cites W2115293825 @default.
- W2078433449 cites W2118385532 @default.
- W2078433449 cites W2130072278 @default.
- W2078433449 cites W2130352976 @default.
- W2078433449 cites W2146317119 @default.
- W2078433449 cites W2146443559 @default.
- W2078433449 cites W2147259348 @default.
- W2078433449 cites W2150594596 @default.
- W2078433449 cites W2151838237 @default.
- W2078433449 cites W2160369507 @default.
- W2078433449 cites W2169727733 @default.
- W2078433449 cites W2172148460 @default.
- W2078433449 cites W4233889668 @default.
- W2078433449 cites W4313362839 @default.
- W2078433449 cites W4376596156 @default.
- W2078433449 cites W3142959081 @default.
- W2078433449 doi "https://doi.org/10.2353/ajpath.2009.090156" @default.
- W2078433449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2731116" @default.
- W2078433449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19679874" @default.
- W2078433449 hasPublicationYear "2009" @default.
- W2078433449 type Work @default.
- W2078433449 sameAs 2078433449 @default.
- W2078433449 citedByCount "73" @default.
- W2078433449 countsByYear W20784334492012 @default.
- W2078433449 countsByYear W20784334492013 @default.