Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078436043> ?p ?o ?g. }
- W2078436043 endingPage "833" @default.
- W2078436043 startingPage "873" @default.
- W2078436043 abstract "The neurotransmitter noradrenaline (NA) exerts important antiinflammatory effects on glial cells including suppression of the inducible form of nitric oxide synthase (NOS2). The authors examined the consequences of manipulating NA in vivo by treating adult rats with the neurotoxin DSP4, which selectively lesions noradrenergic neurons of the locus ceruleus (LC), and reduces cortical NA levels. Following LC lesion, intracortical injection of aggregated amyloid beta 1–42 (Aβ1–42) caused appearance of NOS2 within neurons, and increased neuronal damage assessed by staining for nonphosphorylated neurofilament proteins with antibody SMI-32. Co-treatment with a selective α2-adrenergic antagonist reduced neuronal NOS2 staining as well as SMI-32 staining. Neuronal damage was dependent on NOS2 expression since injection of Aβ1–42 into DSP4-treated NOS2-deficient mice did not result in neuronal damage. These results demonstrate that decrease of NA levels in vivo can exacerbate inflammatory responses and neuronal damage due to inflammatory stimuli such as Aβ. These findings suggest that α2-adrenergic antagonists could provide therapeutic benefit in neurological diseases such as AD or PD where LC loss is known to occur." @default.
- W2078436043 created "2016-06-24" @default.
- W2078436043 creator A5019333966 @default.
- W2078436043 creator A5028263102 @default.
- W2078436043 creator A5035103700 @default.
- W2078436043 creator A5036362891 @default.
- W2078436043 creator A5036922002 @default.
- W2078436043 creator A5078026731 @default.
- W2078436043 creator A5082035714 @default.
- W2078436043 creator A5082523051 @default.
- W2078436043 creator A5089750087 @default.
- W2078436043 date "2006-05-01" @default.
- W2078436043 modified "2023-09-23" @default.
- W2078436043 title "Beta-Amyloid-Dependent Expression of NOS2in Neurons: Prevention by an α2-Adrenergic Antagonist" @default.
- W2078436043 cites W1171331324 @default.
- W2078436043 cites W1585801143 @default.
- W2078436043 cites W1588700422 @default.
- W2078436043 cites W1646743268 @default.
- W2078436043 cites W1662308449 @default.
- W2078436043 cites W1667686291 @default.
- W2078436043 cites W1675417996 @default.
- W2078436043 cites W1684025987 @default.
- W2078436043 cites W1964912342 @default.
- W2078436043 cites W1967791587 @default.
- W2078436043 cites W1968443425 @default.
- W2078436043 cites W1972528195 @default.
- W2078436043 cites W1975656289 @default.
- W2078436043 cites W1976491350 @default.
- W2078436043 cites W1980591250 @default.
- W2078436043 cites W1983783671 @default.
- W2078436043 cites W1986697341 @default.
- W2078436043 cites W1988210470 @default.
- W2078436043 cites W1988533632 @default.
- W2078436043 cites W1989730087 @default.
- W2078436043 cites W1991356078 @default.
- W2078436043 cites W1991484350 @default.
- W2078436043 cites W1998846538 @default.
- W2078436043 cites W1999131027 @default.
- W2078436043 cites W1999890389 @default.
- W2078436043 cites W2001553312 @default.
- W2078436043 cites W2011994668 @default.
- W2078436043 cites W2016069566 @default.
- W2078436043 cites W2019845863 @default.
- W2078436043 cites W2021388250 @default.
- W2078436043 cites W2021992999 @default.
- W2078436043 cites W2023026189 @default.
- W2078436043 cites W2025130734 @default.
- W2078436043 cites W2025513198 @default.
- W2078436043 cites W2030567615 @default.
- W2078436043 cites W2033010144 @default.
- W2078436043 cites W2034361309 @default.
- W2078436043 cites W2035139640 @default.
- W2078436043 cites W2038917935 @default.
- W2078436043 cites W2043159644 @default.
- W2078436043 cites W2046818023 @default.
- W2078436043 cites W2048508373 @default.
- W2078436043 cites W2049054934 @default.
- W2078436043 cites W2049670306 @default.
- W2078436043 cites W2056189993 @default.
- W2078436043 cites W2068440136 @default.
- W2078436043 cites W2070046033 @default.
- W2078436043 cites W2071553665 @default.
- W2078436043 cites W2073557865 @default.
- W2078436043 cites W2074077715 @default.
- W2078436043 cites W2074901704 @default.
- W2078436043 cites W2077362117 @default.
- W2078436043 cites W2079946966 @default.
- W2078436043 cites W2080803011 @default.
- W2078436043 cites W2082363371 @default.
- W2078436043 cites W2083025131 @default.
- W2078436043 cites W2086061872 @default.
- W2078436043 cites W2087228485 @default.
- W2078436043 cites W2087350257 @default.
- W2078436043 cites W2091590679 @default.
- W2078436043 cites W2093019685 @default.
- W2078436043 cites W2094613247 @default.
- W2078436043 cites W2107282184 @default.
- W2078436043 cites W2122515902 @default.
- W2078436043 cites W2154604887 @default.
- W2078436043 cites W2158635731 @default.
- W2078436043 cites W2163361704 @default.
- W2078436043 cites W2168025729 @default.
- W2078436043 cites W22231678 @default.
- W2078436043 cites W2313298280 @default.
- W2078436043 cites W4247648661 @default.
- W2078436043 cites W4297833723 @default.
- W2078436043 doi "https://doi.org/10.1089/ars.2006.8.873" @default.
- W2078436043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16771677" @default.
- W2078436043 hasPublicationYear "2006" @default.
- W2078436043 type Work @default.
- W2078436043 sameAs 2078436043 @default.
- W2078436043 citedByCount "30" @default.
- W2078436043 countsByYear W20784360432012 @default.
- W2078436043 countsByYear W20784360432013 @default.
- W2078436043 countsByYear W20784360432014 @default.
- W2078436043 countsByYear W20784360432015 @default.
- W2078436043 countsByYear W20784360432016 @default.
- W2078436043 countsByYear W20784360432017 @default.