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• W2078437681 abstract "K+ currents were studied at a normal (-69 mV) and at a depolarized (-49 mV) membrane potential in voltage-clamped squid giant axons perfused with 350 mM-K+ and bathed in K+-free artificial sea water containing tetrodotoxin to block the Na+ channels. Steady-state and instantaneous K+ currents were reduced by over 50% at corresponding voltages at the depolarized membrane potential. Instantaneous chord conductance-voltage curves showed that the depolarized membrane potential caused a uniform reduction of K+ conductance across the voltage range under study. The driving force for K+ ions was comparable at both membrane potentials when a short (2 ms) pre-pulse was used to open the K+ channels. When a longer (7.5 ms) pre-pulse was used, the driving force was actually larger at the depolarized membrane potential. The depolarized membrane potential did drive some K+ ions into the periaxonal space. The amount of K+ ions driven into the periaxonal space was estimated by two independent methods, with similar results. The resulting increase of K+ ions in the periaxonal space (10 mM) was about 40 times too small to account for the large reduction in currents in terms of a reduced driving force for K+ ions. The kinetics of recovery and development of inactivation were monitored by repeatedly applying a 7.5 ms test pulse followed by a long conditioning potential. Both recovery and development of inactivation, from the depolarized membrane potential, were described by the sum of two exponential terms plus a constant. The time constant-voltage curves for both phases of inactivation peaked at about -54 mV at 10 degrees C. The time constant of the slow phase of inactivation at -54 mV was about 12.4 s, while the corresponding time constant for the fast phase was about 2.3 s. The slow relaxation had an apparent plateau of about 11 s at more depolarized membrane potentials. Recovery from inactivation was rapid at hyperpolarized membrane potentials. The steady-state inactivation curve of the K+ channel was incomplete in the depolarizing region; and apparent plateau was reached with about 75% of the K+ current inactivated. The temperature sensitivity of both phases of inactivation corresponded to a Q10 of about 3. Elevated external concentrations of K+ ions did not block either phase of the inactivation process, although the kinetics of recovery from inactivation were slightly faster under these conditions.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2078437681 created "2016-06-24" @default.
• W2078437681 creator A5078016995 @default.
• W2078437681 date "1984-11-01" @default.
• W2078437681 modified "2023-10-18" @default.
• W2078437681 title "The kinetics of recovery and development of potassium channel inactivation in perfused squid (Loligo pealei) giant axons." @default.
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• W2078437681 doi "https://doi.org/10.1113/jphysiol.1984.sp015460" @default.
• W2078437681 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1193159" @default.
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• W2078437681 hasPublicationYear "1984" @default.
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