FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078441627> ?p ?o ?g. }

• W2078441627 endingPage "414" @default.
• W2078441627 startingPage "391" @default.
• W2078441627 abstract "An integrative, systems approach to the modelling of brain energy metabolism is presented. Mechanisms such as glutamate cycling between neurons and astrocytes and glycogen storage in astrocytes have been implemented. A unique feature of the model is its calibration using in vivo data of brain glucose and lactate from freely moving rats under various stimuli. The model has been used to perform simulated perturbation experiments that show that glycogen breakdown in astrocytes is significantly activated during sensory (tail pinch) stimulation. This mechanism provides an additional input of energy substrate during high consumption phases. By way of validation, data from the perfusion of 50 µM propranolol in the rat brain was compared with the model outputs. Propranolol affects the glucose dynamics during stimulation, and this was accurately reproduced in the model by a reduction in the glycogen breakdown in astrocytes. The model’s predictive capacity was verified by using data from a sensory stimulation (restraint) that was not used for model calibration. Finally, a sensitivity analysis was conducted on the model parameters, this showed that the control of energy metabolism and transport processes are critical in the metabolic behaviour of cerebral tissue." @default.
• W2078441627 created "2016-06-24" @default.
• W2078441627 creator A5022605437 @default.
• W2078441627 creator A5042246300 @default.
• W2078441627 creator A5047255137 @default.
• W2078441627 creator A5058739895 @default.
• W2078441627 date "2009-04-25" @default.
• W2078441627 modified "2023-10-03" @default.
• W2078441627 title "An integrative dynamic model of brain energy metabolism using in vivo neurochemical measurements" @default.
• W2078441627 cites W1484198052 @default.
• W2078441627 cites W1508189994 @default.
• W2078441627 cites W1510842361 @default.
• W2078441627 cites W1512700032 @default.
• W2078441627 cites W1806555373 @default.
• W2078441627 cites W1970997910 @default.
• W2078441627 cites W1997295596 @default.
• W2078441627 cites W1999087101 @default.
• W2078441627 cites W2014201583 @default.
• W2078441627 cites W2043403270 @default.
• W2078441627 cites W2052750469 @default.
• W2078441627 cites W2055908419 @default.
• W2078441627 cites W2056564317 @default.
• W2078441627 cites W2062245653 @default.
• W2078441627 cites W2081755645 @default.
• W2078441627 cites W2092635505 @default.
• W2078441627 cites W2094784513 @default.
• W2078441627 cites W2096822244 @default.
• W2078441627 cites W2101969014 @default.
• W2078441627 cites W2114850890 @default.
• W2078441627 cites W2115343689 @default.
• W2078441627 cites W2126497605 @default.
• W2078441627 cites W2148611607 @default.
• W2078441627 cites W2161480852 @default.
• W2078441627 cites W2162781359 @default.
• W2078441627 cites W2500402711 @default.
• W2078441627 cites W81801931 @default.
• W2078441627 doi "https://doi.org/10.1007/s10827-009-0152-8" @default.
• W2078441627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19396534" @default.
• W2078441627 hasPublicationYear "2009" @default.
• W2078441627 type Work @default.
• W2078441627 sameAs 2078441627 @default.
• W2078441627 citedByCount "98" @default.
• W2078441627 countsByYear W20784416272012 @default.
• W2078441627 countsByYear W20784416272013 @default.
• W2078441627 countsByYear W20784416272014 @default.
• W2078441627 countsByYear W20784416272015 @default.
• W2078441627 countsByYear W20784416272016 @default.
• W2078441627 countsByYear W20784416272017 @default.
• W2078441627 countsByYear W20784416272018 @default.
• W2078441627 countsByYear W20784416272019 @default.
• W2078441627 countsByYear W20784416272020 @default.
• W2078441627 countsByYear W20784416272021 @default.
• W2078441627 countsByYear W20784416272022 @default.
• W2078441627 countsByYear W20784416272023 @default.
• W2078441627 crossrefType "journal-article" @default.
• W2078441627 hasAuthorship W2078441627A5022605437 @default.
• W2078441627 hasAuthorship W2078441627A5042246300 @default.
• W2078441627 hasAuthorship W2078441627A5047255137 @default.
• W2078441627 hasAuthorship W2078441627A5058739895 @default.
• W2078441627 hasBestOaLocation W20784416272 @default.
• W2078441627 hasConcept C150903083 @default.
• W2078441627 hasConcept C169760540 @default.
• W2078441627 hasConcept C170493617 @default.
• W2078441627 hasConcept C185592680 @default.
• W2078441627 hasConcept C186060115 @default.
• W2078441627 hasConcept C207001950 @default.
• W2078441627 hasConcept C24998067 @default.
• W2078441627 hasConcept C25457674 @default.
• W2078441627 hasConcept C25876315 @default.
• W2078441627 hasConcept C2777499176 @default.
• W2078441627 hasConcept C55493867 @default.
• W2078441627 hasConcept C61174792 @default.
• W2078441627 hasConcept C86803240 @default.
• W2078441627 hasConceptScore W2078441627C150903083 @default.
• W2078441627 hasConceptScore W2078441627C169760540 @default.
• W2078441627 hasConceptScore W2078441627C170493617 @default.
• W2078441627 hasConceptScore W2078441627C185592680 @default.
• W2078441627 hasConceptScore W2078441627C186060115 @default.
• W2078441627 hasConceptScore W2078441627C207001950 @default.
• W2078441627 hasConceptScore W2078441627C24998067 @default.
• W2078441627 hasConceptScore W2078441627C25457674 @default.
• W2078441627 hasConceptScore W2078441627C25876315 @default.
• W2078441627 hasConceptScore W2078441627C2777499176 @default.
• W2078441627 hasConceptScore W2078441627C55493867 @default.
• W2078441627 hasConceptScore W2078441627C61174792 @default.
• W2078441627 hasConceptScore W2078441627C86803240 @default.
• W2078441627 hasIssue "3" @default.
• W2078441627 hasLocation W20784416271 @default.
• W2078441627 hasLocation W20784416272 @default.
• W2078441627 hasLocation W20784416273 @default.
• W2078441627 hasOpenAccess W2078441627 @default.
• W2078441627 hasPrimaryLocation W20784416271 @default.
• W2078441627 hasRelatedWork W1564132981 @default.
• W2078441627 hasRelatedWork W2041197933 @default.
• W2078441627 hasRelatedWork W2051398123 @default.
• W2078441627 hasRelatedWork W2167089286 @default.
• W2078441627 hasRelatedWork W2414288209 @default.
• W2078441627 hasRelatedWork W2791492122 @default.

• next