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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078441657> ?p ?o ?g. }

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• W2078441657 abstract "An efficient and short synthetic route to a novel decadentate ligand 7-[2-(bis-carboxymethyl-amino)-ethyl]-4,10-bis-carboxymethyl-1,4,7,10-tetraaza-cyclododec-1-yl-acetic acid (DEPA) with both macrocyclic and acyclic binding moieties is reported. A reproducible and scalable synthetic method to a precursor molecule of DEPA, 1,4,7-tris(tert-butoxycarbonylmethyl)tetraazacyclododecane was developed. DEPA was evaluated as a chelator of 177Lu, 212Bi, and 213Bi for potential use in an antibody-targeted cancer therapy, radioimmunotherapy (RIT) using Arsenazo III based spectroscopic complexation kinetics, in vitro serum stability, and in vivo biodistribution studies." @default.
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• W2078441657 date "2008-11-01" @default.
• W2078441657 modified "2023-09-27" @default.
• W2078441657 title "Synthesis and biological evaluation of a novel decadentate ligand DEPA" @default.
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• W2078441657 doi "https://doi.org/10.1016/j.bmcl.2008.09.063" @default.
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